β-Estradiol 17-acetate enhances the vitality of endothelial cells isolated from the brain of patients subjected to neurosurgery.

In the current landscape of endothelial cell isolation for building in vitro models of the blood-brain barrier, our work moves towards reproducing the features of the neurovascular unit to achieve glial compliance through an innovative biomimetic coating technology for brain chronic implants. We hypothesized that the autologous origin of human brain microvascular endothelial cells (hBMECs) is the first requirement for the suitable coating to prevent the glial inflammatory response triggered by foreign neuroprosthetics. Therefore, this study established a new procedure to preserve the in vitro viability of hBMECs isolated from gray and white matter specimens taken from neurosurgery patients.

Developmental Coordination Disorder: State of the Art and Future Directions from a Neurophysiological Perspective.

Developmental coordination disorder (DCD) is a common neurodevelopmental condition characterized by disabling motor impairments being visible from the first years of life. Over recent decades, research in this field has gained important results, showing alterations in several processes involved in the regulation of motor behavior (e.g.

From Endorsement of Ambivalent Sexism to Psychological IPV Victimization: The Role of Attitudes Supportive of IPV, Legitimating Myths of IPV, and Acceptance of Psychological Aggression.

Research on intimate partner violence (IPV) has recognized psychological abuse as a precursor of physical and sexual violence in intimate relationships. However, risk factors in predicting women's psychological abuse victimization in such a context are still unclear. The goal of the present work was to investigate the role of ambivalent sexism on psychological IPV victimization, by taking into account in the same study the effect of three additional social-psychological factors: women's (i) attitudes supportive of IPV, (ii) endorsement of legitimating myths of IPV, and (iii) acceptance of psychological aggression in intimate relationships.

A questionnaire to collect unintended effects of transcranial magnetic stimulation: A consensus based approach.

Transcranial magnetic stimulation (TMS) has been widely used in both clinical and research practice. However, TMS might induce unintended sensations and undesired effects as well as serious adverse effects. To date, no shared forms are available to report such unintended effects.

Decreased Frontal Gamma Activity in Alzheimer Disease Patients.

Objective: In Alzheimer disease (AD) animal models, synaptic dysfunction has recently been linked to a disorder of high-frequency neuronal activity. In patients, a clear relation between AD and oscillatory activity remains elusive. Here, we attempt to shed light on this relation by using a novel approach combining transcranial magnetic stimulation and electroencephalography (TMS-EEG) to probe oscillatory activity in specific hubs of the frontoparietal network in a sample of 60 mild-to-moderate AD patients.

Innovative Nanomaterials for Biomedical Applications.

Research focusing on innovative nanomaterials for applications in biomedicine and bioengineering has steadily gained attention over the last 20 years [...

Interpersonal synchronization of movement intermittency.

Most animal species group together and coordinate their behavior in quite sophisticated manners for mating, hunting, or defense purposes. In humans, coordination at a level (the pacing of movements) is evident both in daily life (e.g.

Critical current for giant Fano factor in neural models with bistable firing dynamics and implications for signal transmission.

Bistability in the firing rate is a prominent feature in different types of neurons as well as in neural networks. We show that for a constant input below a critical value, such bistability can lead to a giant spike-count diffusion. We study the transmission of a periodic signal and demonstrate that close to the critical bias current, the signal-to-noise ratio suffers a sharp increase, an effect that can be traced back to the giant diffusion and large Fano factor.

Poly(3,4-ethylenedioxythiophene)-Based Neural Interfaces for Recording and Stimulation: Fundamental Aspects and In Vivo Applications.

Next-generation neural interfaces for bidirectional communication with the central nervous system aim to achieve the intimate integration with the neural tissue with minimal neuroinflammatory response, high spatio-temporal resolution, very high sensitivity, and readout stability. The design and manufacturing of devices for low power/low noise neural recording and safe and energy-efficient stimulation that are, at the same time, conformable to the brain, with matched mechanical properties and biocompatibility, is a convergence area of research where neuroscientists, materials scientists, and nanotechnologists operate synergically. The biotic-abiotic neural interface, however, remains a formidable challenge that prompts for new materials platforms and innovation in device layouts.

Run with the Brownian Hare, Hunt with the Deterministic Hounds.

We present analytic results for mean capture time and energy expended by a pack of deterministic hounds actively chasing a randomly diffusing prey. Depending on the number of chasers, the mean capture time as a function of the prey's diffusion coefficient can be monotonically increasing, decreasing, or attain a minimum at a finite value. Optimal speed and number of chasing hounds exist and depend on each chaser's baseline power consumption.

On the longevity of flexible neural interfaces: Establishing biostability of polyimide-based intracortical implants.

Flexible neural implants are extremely favored, as the most successful strategy to promote probe-tissue integration and avoid severe gliosis relies on reducing the mechanical mismatch between probe and brain tissue. But what are the realistic requirements for achieving chronic recording stability? What are the critical dimensions and main factors determining glial scar-free device integration? To answer these questions, two types of hair-sized polyimide-based flexible intracortical (PIXI) arrays were fabricated, differing only in their cross-sectional area. Chronic tissue reaction to both types was evaluated in rats, and in different implantation setups.

[Re]moving Bodies - A Shared Diminished Reality Installation for Exploring Relational Movement.

In this article we explore an epistemic approach we name dis/embodiment and introduce "Articulations," an interdisciplinary project bringing together Virtual Reality (VR) designers, cognitive scientists, dancers, anthropologists, and human-machine interaction specialists. According to Erin Manning, our sense of self and other emerges from processes of bodying and relational movement (becoming oneself by moving in relation with the world). The aim of the project is to exploit the potential of multi-person VR in order to explore the intersubjective dynamics of relational movement and bodying, and to do so with scientific, artistic and therapeutic purposes in mind.

Implicit Associations between Adverbs of Place and Actions in the Physical and Digital Space.

Neuropsychological, behavioral, and neurophysiological evidence indicates that the coding of space as near and far depends on the involvement of different neuronal circuits. These circuits are recruited on the basis of functional parameters, not of metrical ones, reflecting a general distinction of human behavior, which alternatively attributes to the individual the role of agent or observer. Although much research in cognitive psychology was devoted to demonstrating that language and concepts are rooted in the sensorimotor system, no study has investigated the presence of implicit associations between different adverbs of place ( vs.

The role of dorsal premotor cortex in joint action stopping.

Human sensorimotor interaction requires mutual behavioral adaptation as well as shared cognitive task representations (Joint Action, JA). Yet, an under-investigated aspect of JA is the neurobehavioral mechanisms employed to stop actions if the context calls for it. Sparse evidence points to the possible contribution of the left dorsal premotor cortex (lPMd) in sculpting movements according to the socio-interactive context.

Changes in reach-to-grasp behaviour over the course of training in rats.

One complex task involving sequence of movements and movement refinement in the rat is the single-pellet reaching task, comprising orientation, transport and withdrawal in sequence. In turn, orientation comprises front wall detection, slot localization and nose poke until reach start. Video recordings of a rat in the reaching box highlighted three stages of temporal training: start of training (ST), forepaw dominance appearance (D) and fully trained (T).

Frozen in (e)motion: How reactive motor inhibition is influenced by the emotional content of stimuli in healthy and psychiatric populations.

Efficient inhibitory control is vital. However, environmental cues can influence motor control especially in an emotional context. One common task to measure inhibitory control is the stop-signal task (SST), which asks participants to respond to go stimuli knowing that on some trials a stop signal will be presented, requiring them to inhibit their response.

Weaker implicit interoception is associated with more negative body image: Evidence from gastric-alpha phase amplitude coupling and the heartbeat evoked potential.

Interoception refers to the processing of internal bodily stimuli, while body image refers to appearance-related perceptions, affect, and cognitions. Previous research has found that body image is associated with self-reported and behavioural indices of interoception. Here, we extended this research by examining associations between measures of positive (i.

Evaluation of the In Vitro Biocompatibility of PEDOT:Nafion Coatings.

Poly(3,4-ethylenedioxythiophene)-Nafion (PEDOT:Nafion) is emerging as a promising alternative to PEDOT-polystyrene sulfonate (PEDOT:PSS) in organic bioelectronics. However, the biocompatibility of PEDOT:Nafion has not been investigated to date, limiting its deployment toward in vivo applications such as neural recording and stimulation. In the present study, the in vitro cytotoxicity of PEDOT:Nafion coatings, obtained by a water-based PEDOT:Nafion formulation, was evaluated using a primary cell culture of rat fibroblasts.

Neurons of rat motor cortex become active during both grasping execution and grasping observation.

In non-human primates, a subset of frontoparietal neurons (mirror neurons) respond both when an individual executes an action and when it observes another individual performing a similar action. Mirror neurons constitute an observation and execution matching system likely involved in others' actions processing and in a large set of complex cognitive functions. Here, we show that the forelimb motor cortex of rats contains neurons presenting mirror properties analogous to those observed in macaques.

Empathy and Schadenfreude in Human-Robot Teams.

Intergroup dynamics shape the ways in which we interact with other people. We feel more empathy towards ingroup members compared to outgroup members, and can even feel pleasure when an outgroup member experiences misfortune, known as schadenfreude. Here, we test the extent to which these intergroup biases emerge during interactions with robots.

Telerehabilitation in Italy During the COVID-19 Lockdown: A Feasibility and Acceptability Study.

This study examined the feasibility and acceptability of a telerehabilitation program during the COVID-19 pandemic in a sample of adult patients with physical disabilities. Of the twenty-three patients enrolled, 11 agreed to participate in a video-based telerehabilitation program. Barriers and facilitators to the adoption of telerehabilitation were identified and clinical, demographic, and psychological variables were analysed as predictors of success.

Dance Improves Motor, Cognitive, and Social Skills in Children With Developmental Cerebellar Anomalies.

In this multiple single-cases study, we used dance to train sensorimotor synchronization (SMS), motor, and cognitive functions in children with developmental cerebellar anomalies (DCA). DCA are rare dysfunctions of the cerebellum that affect motor and cognitive skills. The cerebellum plays an important role in temporal cognition, including SMS, which is critical for motor and cognitive development.

Prediction of Speech Onset by Micro-Electrocorticography of the Human Brain.

Recent technological advances show the feasibility of offline decoding speech from neuronal signals, paving the way to the development of chronically implanted speech brain computer interfaces (sBCI). Two key steps that still need to be addressed for the online deployment of sBCI are, on the one hand, the definition of relevant design parameters of the recording arrays, on the other hand, the identification of robust physiological markers of the patient's intention to speak, which can be used to online trigger the decoding process. To address these issues, we acutely recorded speech-related signals from the frontal cortex of two human patients undergoing awake neurosurgery for brain tumors using three different micro-electrocorticographic ([Formula: see text]ECoG) devices.