Effect of a multidisciplinary lifestyle intervention on body composition in people with osteoarthritis: Secondary analysis of the "Plants for Joints" randomized controlled trial.

Objective: The Plants for Joints (PFJ) intervention significantly improved pain, stiffness, and physical function, and metabolic outcomes, in people with metabolic syndrome-associated osteoarthritis (MSOA). This secondary analysis investigated its effects on body composition.

Method: In the randomized PFJ study, people with MSOA followed a 16-week intervention based on a whole-food plant-based diet, physical activity, and stress management, or usual care.

A multidisciplinary lifestyle program for metabolic syndrome-associated osteoarthritis: the "Plants for Joints" randomized controlled trial.

Objective: To determine the effectiveness of the "Plants for Joints" multidisciplinary lifestyle program in patients with metabolic syndrome-associated osteoarthritis (MSOA).

Design: Patients with hip or knee MSOA were randomized to the intervention or control group. The intervention group followed a 16-week program in addition to usual care based on a whole food plant-based diet, physical activity, and stress management.

A multidisciplinary lifestyle program for rheumatoid arthritis: the 'Plants for Joints' randomized controlled trial.

Objective: To determine the effect of a multidisciplinary lifestyle program in patients with RA with low-moderate disease activity.

Methods: In the 'Plants for Joints' (PFJ) parallel-arm, assessor-blind randomized controlled trial, patients with RA and 28-joint DAS (DAS28) ≥2.6 and ≤5.

Defining hip pain trajectories in early symptomatic hip osteoarthritis--5 year results from a nationwide prospective cohort study (CHECK).

Objective: To define distinct hip pain trajectories in individuals with early symptomatic hip osteoarthritis (OA) and to determine risk factors for these pain trajectories.

Method: Data were obtained from the nationwide prospective Cohort Hip and Cohort Knee (CHECK) study. Participants with hip pain or stiffness and a completed 5-year follow-up were included.

Systemic biochemical markers of joint metabolism and inflammation in relation to radiographic parameters and pain of the knee: data from CHECK, a cohort of early-osteoarthritis subjects.

Objective: To investigate associations of biochemical markers of joint metabolism and inflammation with minimum joint space width (JSW) and osteophyte area (OP area) of knees showing no or doubtful radiographic osteoarthritis (OA) and to investigate whether these differed between painful and non-painful knees.

Design: Serum (s-) and urinary (u-) levels of the cartilage markers uCTX-II, sCOMP, sPIIANP, and sCS846, bone markers uCTX-I, uNTX-I, sPINP, and sOC, synovial markers sPIIINP and sHA, and inflammation markers hsCRP and erythrocyte sedimentation rate (ESR) were assessed in subjects from CHECK (Cohort Hip and Cohort Knee) demonstrating Kellgren and Lawrence grade ≤1 OA on knee radiographs. Minimum JSW and OP area of these knees were quantified in detail using Knee Images Digital Analysis (KIDA).

Lateral trunk motion and knee pain in osteoarthritis of the knee: a cross-sectional study.

Background: Patients with osteoarthritis of the knee may change their gait in an attempt to reduce loading of the affected knee, thereby reducing pain. Especially changes in lateral trunk motion may be potentially effective, since these will affect the position of the centre of mass relative to the knee, enabling minimization of the load on the knee and thereby knee pain. The aim of the study was to test the hypothesis that a higher level of knee pain is associated with higher lateral trunk motion in patients with knee OA.

Prediction of walking disability by disease-related factors in patients with rheumatoid arthritis.

Objective: To investigate the relationship between disease-related factors and walking disability in different phases of rheumatoid arthritis; and to predict future walking disability in rheumatoid arthritis, using disease-related factors assessed 2 years after diagnosis.

Methods: A cohort of 848 newly diagnosed patients with rheumatoid arthritis was followed up for a maximum of 8 years. Walking disability and several disease-related and demographic factors were recorded during follow-up.

Reasons for drop-out in rehabilitation treatment of native patients and non-native patients with chronic low back pain in the Netherlands: a medical file study.

Aim: Drop-out of rehabilitation treatment in non-native patients with chronic low back pain has been reported to be higher than in native Dutch patients. It was expected that drop-out in non-native patients would be due to different expectations on the content of rehabilitation treatment and due to language or communication problems. Aim of this study was to determine differences in reasons for drop-out between native patients and non-native patients with chronic non-specific low back pain participating in a rehabilitation program.

Interobserver reliability of the Amsterdam Severity Scale in Stenosing Tenosynovitis (ASSiST).

Study Design: Interobserver reliability study.

Introduction: A scale was developed to measure the severity of stenosing tenosynovitis: the Amsterdam Severity Scale in Stenosing Tenosynovitis (ASSiST).

Purpose Of The Study: To study the interobserver reliability of the ASSiST.

Knee varus-valgus motion during gait--a measure of joint stability in patients with osteoarthritis?

Objective: To determine the validity of varus-valgus motion as a measure of knee joint stability by establishing the relationship of varus-valgus motion with muscle strength, joint proprioception, joint laxity and skeletal alignment in patients with knee osteoarthritis (OA).

Methods: Sixty-three patients with OA of the knee were tested. Varus-valgus motion was determined with a video-based optoelectronic gait analysis system.

Varus-valgus motion and functional ability in patients with knee osteoarthritis.

Objective: To assess the relationship between knee varus-valgus motion and functional ability, and the impact of knee varus-valgus motion on the relationship between muscle strength and functional ability in patients with osteoarthritis (OA) of the knee.

Methods: Sixty-three patients with knee OA were tested. Varus-valgus motion was assessed by optoelectronic recording and three-dimensional motion analysis.

Cyclic loading is harmful to articular cartilage from which proteoglycans have been partially depleted by retinoic acid.

We studied whether cyclic loading is harmful to degraded cartilage. Sets of four cartilage-bearing sesamoid bones were dissected from 5-year old cows. One bone from each set was cultured for 17 h in control medium to serve as an ex vivo control.

Interleukin-1 reversibly inhibits the synthesis of biglycan and decorin in intact articular cartilage in culture.

Objective: To study the effect of interleukin-1 (IL-1) on the synthesis of proteoglycans biglycan (DSPG-I) and decorin (DSPG-II) in intact bovine articular cartilage.

Methods: Cartilage bearing sesamoid bones from the metacarpophalangeal joint were cultured with 10 ng/ml IL-1 for 2 days and labelled with [35S] sulfate. One sesamoid bone from each animal had been labelled ex vivo.

Irreversible changes in glycosaminoglycan composition of anatomically intact bovine articular cartilage induced by intermittent loading.

The changes in matrix composition induced by I MPa intermittent (0.2 Hz) loading of anatomically intact bovine articular cartilage in vitro are studied. The kinetics of chondrocyte response was determined in experiments where sesamoid bones of adult cows were loaded for 0, 3, 5 and 7 days.

Transforming growth factor-beta stimulates retinoic acid-induced proteoglycan depletion in intact articular cartilage.

Cartilage-bearing sesamoid bones from the metacarpophalangeal joints of adult cows were cultured with retinoic acid for 1 week and allowed to recover in control medium for another 2 weeks. Retinoic acid decreased the proteoglycan synthesis of the cartilage to 33% of control values, and induced 26% loss of proteoglycans from the matrix. During recovery, the synthesis of proteoglycans returned to the control level but their content remained reduced.

Intermittent loading induces the expression of 3-B-3(-) epitope in cultured bovine articular cartilage.

Objective: To study the effects of intermittent loading on the proteoglycans synthesized in intact cultured articular cartilage.

Methods: Sesamoid bones carrying articular cartilage were subjected to cyclic loading in vitro for one week. A new procedure to fix and decalcify the tissue was developed and an immunohistochemical analysis of the expression of 3-B-3(-) epitope in the articular cartilage was carried out.

Proteoglycan depletion of intact articular cartilage by retinoic acid is irreversible and involves loss of hyaluronate.

Intact sesamoid bones from bovine metacarpophalangeal joints were cultured with retinoic acid for 9 days and allowed to recover in control medium for up to 17 days. Retinoic acid (300 ng/ml) induced 91.8% inhibition of glycosaminoglycan (GAG) synthesis and 50.

Kinetics of proteoglycan turnover in bovine articular cartilage explants.

The turnover of proteoglycans was studied in explant cultures of mature bovine articular cartilage. The aim of the study was to compare the in vitro turnover rates of newly synthesized proteoglycans and endogenous proteoglycans. Cartilage was maintained in the presence of various serum concentrations in order to determine the conditions of steady-state proteoglycan metabolism.

Effects of loading on the synthesis of proteoglycans in different layers of anatomically intact articular cartilage in vitro.

The anatomically intact articular cartilage (approximately equal to 2.5 cm2) of whole bovine sesamoid bones was cultured on its bone support. A load of 5 kg was applied intermittently at 0.

Age related changes in the turnover of proteoglycans from explants of bovine articular cartilage.

Articular cartilage in explant culture synthesized 2 proteoglycan types of different size. The proportion of 35S-sulfate incorporated into the small proteoglycan was higher in mature (17%) than in immature cartilage (11%). The chondroitin sulfate chains of both proteoglycans, synthesized by mature cartilage were shorter than those of immature cartilage, with a higher ratio of 6-sulfated over 4-sulfated disaccharides.

Composition of proteoglycans synthesized in different layers of cultured anatomically intact articular cartilage.

Calf articular cartilage was cultured anatomically intact on its natural bone-support. At day 0 and day 7, respectively, the cartilage was radiolabeled, washed and harvested in 3 successive layers parallel to the articular surface. The proteoglycans were studied after extraction by 4 M guanidine hydrochloride.

A Staphylococcus aureus factor exclusively removes large proteoglycan monomers from explants of articular cartilage.

Exposure of explants of viable, as well as freeze-thawed, bovine articular cartilage to culture filtrates of Staphylococcus aureus increased the release of proteoglycans from the tissue significantly within 24 h. The S. aureus factor exclusively releases the large, 4 M guanidinium extractable proteoglycans from the matrix; the small proteoglycans are not affected by this factor.

Application of the ICIDH in rehabilitation medicine.

A screening instrument for disabilities, based on the D Code of the ICIDH, has been constructed. It is intended for use in the daily routine of rehabilitation medicine. The instrument consists of 28 items in five ability categories.