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Center for Renal Medicine[Affiliation] Publications | LitMetric
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Proximal tubular epithelial insulin receptor mediates high-fat diet-induced kidney injury.

JCI Insight

February 2021

Center for Renal Medicine, Division of Nephrology.

Hak Joo Lee Meenalakshmi M Mariappan Luke Norton Terry Bakewell Denis Feliers

The role of insulin receptor (IR) activated by hyperinsulinemia in obesity-induced kidney injury is not well understood. We hypothesized that activation of kidney proximal tubule epithelial IR contributes to obesity-induced kidney injury. We administered normal-fat diet (NFD) or high-fat diet (HFD) to control and kidney proximal tubule IR-knockout (KPTIRKO) mice for 4 months.

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