386 results match your criteria: "Center for Pain Medicine[Affiliation]"

The association between childhood maltreatment and pain sensitivity in a high-risk adolescent population.

J Pain

November 2024

Department of Psychiatry, Erasmus University Medical Center Rotterdam, the Netherlands; Epidemiological and Social Psychiatric Research Institute (ESPRi), Department of Psychiatry, Erasmus University Medical Center, Rotterdam, the Netherlands. Electronic address:

The risk of developing chronic pain is twice as high among people with a history of childhood maltreatment compared to those without these experiences. It is unclear, however, whether childhood maltreatment might lead to lower or higher perception of pain. In this paper, we investigate the association between childhood maltreatment and pain sensitivity.

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  • Trigeminal neuralgia causes severe facial pain, and percutaneous balloon compression (PBC) is a common treatment, though it can provoke trigeminocardiac reflex (TCR), resulting in heart complications.
  • This study compares the effects of remimazolam and propofol anesthesia on the occurrence of TCR during PBC in patients with trigeminal neuralgia.
  • Results showed that remimazolam significantly reduced the incidence of TCR and severe TCR compared to propofol, while also maintaining a higher heart rate, with no increase in adverse events.
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How does the brain emerge from anesthesia and regain consciousness.

Chin Med J (Engl)

November 2024

Department of Medical Neuroscience and SUSTech Center for Pain Medicine, Southern University of Science and Technology School of Medicine, Shenzhen, Guangdong 518000, China.

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  • Bone cancer pain (BCP) is really hard to treat, and scientists are still figuring out how it works.
  • This study found that a signaling pathway called Wnt5a/Ryk in certain nerve cells is important for causing BCP when there’s a tumor in the bone.
  • Blocking this Wnt5a/Ryk signaling can help relieve the pain, so it might be a good target for new treatments for people with bone cancer pain.
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Knockdown of BMP7 induced oligodendrocyte apoptosis, demyelination and motor function loss.

Mol Cell Neurosci

December 2024

Department of Pain Management and Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China; Clinical Research Center for Pain Medicine in Hunan Province, Changsha, Hunan, China. Electronic address:

Background: Demyelinating diseases, including multiple sclerosis (MS) and spinal cord injury (SCI), lead to significant neurological deficits primarily due to the loss of oligodendrocytes (OLs). Bone Morphogenetic Protein 7 (BMP7) is expressed abundantly in the central nervous system and previous studies showed its protective effect in reducing OL loss. In this study, we aim to explore BMP7's potential as a biomarker and therapeutic target for demyelinating diseases by investigating its expression and effects on OLs and myelin sheath integrity.

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Intrathecal Drug Delivery System in Prepontine Cistern for Patients with Intractable Craniofacial Cancer Pain: A Multicenter Retrospective Study.

Anesth Analg

September 2024

From the Department of Pain Management and Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Article Synopsis
  • * A study analyzed the safety and effectiveness of inserting an intrathecal morphine pump catheter into the prepontine cistern for patients suffering from this type of cancer pain across eleven medical centers between September 2019 and December 2023.
  • * Findings revealed significant post-surgery reductions in pain levels, with the majority of patients experiencing over 50% pain relief one day and thirty days after the procedure, suggesting this method is a promising alternative for pain management in craniofacial cancer patients.
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10. Complex regional pain syndrome.

Pain Pract

January 2025

Department of Anesthesiology, Center for Pain Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands.

Introduction: Complex regional pain syndrome (CRPS) is a clinical disorder that can develop following surgery or trauma. Based on the most prominent underlying pathophysiological mechanisms, CRPS can be classified into different subtypes, namely inflammatory, nociplastic/neuropathic, vasomotor, and motor. Depending on the subtype, personalized treatment can be applied.

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Background: In mild to moderate lumbar spinal stenosis (LSS) where conservative care treatments fail, minimally invasive treatments, such as interspinous spacers without decompression or fusion (ISD), may be appropriate. While previous studies have demonstrated racial and socioeconomic disparities in the surgical treatment of LSS, there are limited data on how those factors impact accessibility to these procedures. This study explored demographic, socioeconomic, and geographic differences in the use of ISD.

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Introduction: Spinal neurostimulation is a therapy for otherwise intractable chronic pain. Spinal neurostimulation includes stimulation of the spinal cord (SCS), dorsal root ganglion (DRGS), and dorsal root entry zone (DREZS). New paresthesia-free neurostimulation paradigms may rely on different mechanisms of action from those of conventional tonic neurostimulation.

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Bone morphogenetic protein 4 derived from the cerebrospinal fluid in patients with postherpetic neuralgia induces allodynia via the crosstalk between microglia and astrocyte.

Brain Behav Immun

July 2024

Department of Anesthesiology, the Second Xiangya Hospital, Central South University, Changsha, China; Department of Pain Management, the Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China; Hunan Province Center for Clinical Anesthesia and Anesthesiology, Research Institute of Central South University, Changsha, Hunan Province, China; Clinical Research Center for Pain Medicine in Hunan Province, Changsha, Hunan Province, China. Electronic address:

Introduction: During postherpetic neuralgia (PHN), the cerebral spinal fluid (CSF) possesses the capability to trigger glial activation and inflammation, yet the specific changes in its composition remain unclear. Recent findings from our research indicate elevations of central bone morphogenetic protein 4 (BMP4) during neuropathic pain (NP), serving as an independent modulator of glial cells. Herein, the aim of the present study is to test the CSF-BMP4 expressions and its role in the glial modulation in the process of PHN.

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Objectives: Quantitative sensory testing (QST) has been used for decades to study sensory abnormalities in multiple conditions in which the somatosensory system is compromised, including pain. It is commonly used in pharmacologic studies on chronic pain but less so in conjunction with neuromodulation. This review aims to assess the utility of QST in spinal cord stimulation (SCS) protocols.

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Article Synopsis
  • Implanting neuromodulation devices necessitates that pain medicine physicians understand surgical techniques and how to manage wounds after surgery.
  • Physicians should have a grasp of normal wound healing to identify any abnormalities that may arise post-surgery.
  • When healing does not go as planned, it's crucial for doctors to consider a wide range of potential issues, including non-surgical skin-related conditions.
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Intrathecal baclofen (ITB) is used for the treatment of intractable spasticity. The burden of traveling for ITB screening and aftercare is problematic for nursing home residents with severe spasticity and seems to result in undertreatment of spasticity. The aim of this study is to evaluate the effectiveness, safety, and feasibility of ITB for nursing home residents treated in their home, describing the selection phase, the initial trial of ITB, and aftercare up to 3 months after implantation of an ITB pump.

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Spindle component 25 (SPC25) is one of the four proteins that make up the nuclear division cycle 80 (NDC80) complex, the other three components being Ndc80p, Nuf2p, and spindle component 24. Deregulation of the components of this complex can lead to uncontrolled proliferation and reduced apoptosis. However, the prognostic and immunotherapeutic value of SPC25 in pan-cancer remains unclear.

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Tendon injury produces intractable pain and disability in movement, but the medications for analgesia and restoring functional integrity of tendon are still limited. In this study, we report that proteinase-activated receptor 2 (PAR2) activation in dorsal root ganglion (DRG) neurons contributes to chronic pain and tendon histopathological changes produced by Achilles tendon partial transection injury (TTI). Tendon partial transection injury increases the expression of PAR2 protein in both somata of DRG neurons and their peripheral terminals within the injured Achilles tendon.

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Introduction: The Accreditation Council for Graduate Medical Education (ACGME) approved the first pain medicine fellowship programs over three decades ago, designed around a pharmacological philosophy. Following that, there has been a rise in the transition of pain medicine education toward a multidisciplinary interventional model based on a tremendous surge of contemporaneous literature in these areas. This trend has created variability in clinical experience and education amongst accredited pain medicine programs with minimal literature evaluating the differences and commonalities in education and experience of different pain medicine fellowships through Program Director (PD) experiences.

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Diabetic Neuropathic Pain: Directions for Exploring Treatments.

Biomedicines

March 2024

Department of Medical Neuroscience and SUSTech Center for Pain Medicine, Southern University of Science and Technology, Shenzhen 518055, China.

Diabetic neuropathic pain (DNP) is one of the common and severe late-stage complications of diabetes mellitus, which could greatly influence the patients' quality of life. Patients with DNP often experience spontaneous pain and evoked pain such as mechanical allodynia and thermal hyperalgesia, meaning that their physical and psychological health are severely impaired. Unfortunately, the mechanisms of DNP remain highly elusive, so substantial breakthrough in effective DNP targeted treatments is still clinically challenging.

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Neurobiological basis of emergence from anesthesia.

Trends Neurosci

May 2024

Department of Medical Neuroscience and SUSTech Center for Pain Medicine, Southern University of Science and Technology School of Medicine, Shenzhen, China.

The suppression of consciousness by anesthetics and the emergence of the brain from anesthesia are complex and elusive processes. Anesthetics may exert their inhibitory effects by binding to specific protein targets or through membrane-mediated targets, disrupting neural activity and the integrity and function of neural circuits responsible for signal transmission and conscious perception/subjective experience. Emergence from anesthesia was generally thought to depend on the elimination of the anesthetic from the body.

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Background: Adults with refractory, mechanical chronic low back pain associated with impaired neuromuscular control of the lumbar multifidus muscle have few treatment options that provide long-term clinical benefit. This study hypothesized that restorative neurostimulation, a rehabilitative treatment that activates the lumbar multifidus muscles to overcome underlying dysfunction, is safe and provides relevant and durable clinical benefit to patients with this specific etiology.

Materials And Methods: In this prospective five-year longitudinal follow-up of the ReActiv8-B pivotal trial, participants (N = 204) had activity-limiting, moderate-to-severe, refractory, mechanical chronic low back pain, a positive prone instability test result indicating impaired multifidus muscle control, and no indications for spine surgery.

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Article Synopsis
  • Pancreatic cancer causes debilitating visceral pain that affects patients' quality of life, and this study aims to better understand the underlying neural mechanisms using mouse models.
  • Researchers established a mouse model that mimics pancreatic cancer-related visceral pain and used various methods to assess pain levels and the activity of GABAergic neurons.
  • Findings revealed that GABAergic neurons in the paraventricular nucleus of the hypothalamus are key players in managing visceral pain; their destruction worsens pain, while their activation can relieve it, suggesting new treatment targets for this pain type.*
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