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Effect of exercise training on acute (crush lesion) and chronic (diabetes mellitus) peripheral neuropathy in the rat.

Restor Neurol Neurosci

January 1996

Rudolf Magnus Institute for Neurosciences of the Utrecht University, Department of Medical Pharmacology, Postbus 80040, 3508 TA Utrecht, The Netherlands Utrecht University Hospital, Center for Nutritional and Rehabilitation Sciences, Utrecht, The Netherlands.

The effect of moderate exercise training on acute and chronic neuropathy in two separate experiments was examined. Acute nerve dysfunction was induced by sciatic nerve crush lesion and chronic neuropathy by streptozotocin-induced diabetes mellitus (experimental diabetic neuropathy; EDN). Moderate exercise training was achieved by placing food and water, separately, at either end of a U-shaped tubular home cage (8 m).

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