Right Ventricular Injury Definition and Management in Veno-Venous Extracorporeal Membrane Oxygenation.

Right ventricular injury (RVI) in respiratory failure receiving veno-venous extracorporeal membrane oxygenation (VV ECMO) is associated with significant mortality. A scoping review is necessary to map the current literature and guide future research regarding the definition and management of RVI in patients receiving VV ECMO. We searched for relevant publications on RVI in patients receiving VV ECMO in Medline, EMBASE, and Web of Science.

Deloyers Technique for Restoration of Bowel Continuity Following Extended Left Hemicolectomy: A Comprehensive Analysis of 97 Cases and Literature Review.

Background: Deloyers technique addresses challenges in restoring bowel continuity following extended left hemicolectomies. Despite being first described in 1958, the technique remains underutilized, with limited data on long-term outcomes.

Objective: To evaluate the indications, surgical and functional outcomes of Deloyers technique and review existing literature.

Impact of Left Ventricular Size on Outcomes Following HeartMate 3 Left Ventricular Assist Device Implantation: Analysis of the European Registry for Patients With Mechanical Circulatory Support (EUROMACS).

We investigated the association of preimplant left ventricular end-diastolic diameter (LVEDD) with outcomes after HeartMate 3 (HM3) left ventricular assist device (LVAD) implantation. Patients from the European Registry for Patients with Mechanical Circulatory Support (EUROMACS) registry who underwent HM3 implantation from August 2014 to February 2023 (n = 834) were analyzed according to preoperative LVEDD: less than or equal to 65 (n = 251), 65-80 (n = 441), and greater than or equal to 80 mm (n = 142). The mean age was 54.

Creating custom GPTs for faculty development: An example using the Johari Window and Crucial Conversation frameworks for providing feedback to struggling students.

Feedback plays a crucial role in the growth and development of trainees, particularly when addressing areas needing improvement. However, faculty members often struggle to deliver constructive feedback, particularly when discussing underperformance. A key obstacle is the lack of comfort many faculty experience in providing feedback that fosters growth.

Remodeling and Characterization Analysis of Corticospinal Tract in Patients with Intracerebral Hemorrhage in the Basal Ganglia.

To investigate corticospinal tract (CST) injury and remodeling in patients with basal ganglia intracerebral hemorrhage (ICH) and explore the characterization capabilities of the corresponding parameters. In this prospective study, baseline, scale, and diffusion-weighted imaging (DWI) data were collected from patient cohorts. Participants were stratified into favorable (0-3 points) and unfavorable (4-6 points) prognosis groups, based on Modified Rankin Scale (mRS) after 3-6 months.

Survey of Urogynecology Fellows on the Care of Patients with Differences in Sex Development/Intersex Traits.

Introduction And Hypothesis: Patients with differences in sex development or intersex traits (DSD/I) struggle to find clinically competent care in adulthood. We sought to describe the surgical exposure of Urogynecology and Reconstructive Pelvic Surgery (URPS) fellows who had previously trained in ObGyn (URPS-Gyn) to patients with DSD/I and their interest in performing 18 relevant procedures. We hypothesized that most graduating fellows would not have had exposure to many of the surgeries.

Biomarkers.

Background: Diffusion magnetic resonance imaging (dMRI) permits characterizing differences in white matter microstructure associated with amnestic mild cognitive impairment (aMCI) and Alzheimer's dementia (AD). However, most dMRI measures aggregate signals across multiple axonal fiber populations with varying spatial orientations, which limits the sensitivity and specificity of clinical diagnosis. To overcome this shortcoming, we estimated fiber density (FD) measures, independently from crossing fiber populations, and extracellular cerebral spinal fluid (CSF).

Biomarkers.

Background: Aging is linked to significant white matter abnormalities, which are often studied using traditional diffusion tensor imaging (DTI) metrics; however, these traditional metrics have limited sensitivity/specificity to neurobiological characteristics. Here, we use fixel-based analysis (FBA) - an approach with more precision in areas of crossing fibers - to study age-related white matter microstructural decline.

Method: This study uses cross-sectional data from the Vanderbilt Memory & Aging Project cohort [n=325, age at baseline: 72.

Biomarkers.

Background: As new anti-amyloid immunotherapies emerge for Alzheimer's disease (AD), it is clear that early diagnosis of AD pathology is crucial for treatment success. This can be challenging in atypical presentations of AD and, together with our reliance on CSF or PET scans, can, at times, lead to delayed diagnosis. Here, we further explore the possible role of plasma tau phosphorylated at threonine 217 (P-tau217) for the detection of primary AD or AD co-pathology when frontotemporal dementia spectrum disorders are the main clinical presentation.

Biomarkers.

Background: Traumatic encephalopathy syndrome (TES) is the proposed clinical syndrome of the neurodegenerative disease chronic traumatic encephalopathy (CTE). As part of the 2021 TES NINDS consensus diagnostic criteria, certainty levels of underlying CTE neuropathology can be determined (i.e.

Biomarkers.

Background: Sex-specific functional-brain changes during memory tasks have been reported along the Alzheimer's disease (AD) continuum. However, mid-life risk factor effects on memory-related neural activation remain less clear in women with increased AD risk. Here we examined brain activations during a modified pattern-separation task and their associations with verbal memory scores in midlife women at risk for AD due to family history.

Biomarkers.

Background: Older adults with epilepsy represent the largest and fastest-growing segment of individuals with epilepsy and harbor risk factors for pathological aging, including cerebrovascular risk factors (CVRFs) and Alzheimer's disease (AD)-related pathology. In fact, several community-based studies have reported up to a 3-fold increased risk for dementia including AD among individuals with epilepsy. Despite this, identification of risk factors for AD and related dementias (ADRD) remains largely unexplored in epilepsy, which has critical implications for patient care and dementia risk stratification.

Biomarkers.

Background: Diffusion magnetic resonance imaging (dMRI) studies show cerebral white matter alterations are associated with both mild cognitive impairment (MCI) and contextual psychosocial factors. However, these reports are almost exclusively based on older adults residing in metropolitan areas. Individuals living in rural communities face increased risk for Alzheimer's disease and related dementias, but little is known regarding the sensitivity of dMRI markers to incident MCI or psychosocial stressors in this population.

Public Health.

Background: Rural-dwelling older adults are at increased risk for Alzheimer's disease (AD) and related dementia. Identifying how rural living and neighborhood disadvantage affect neurobiology may help to understand rural-urban disparities in AD and promote healthy aging in rural communities. In this study, we characterize rural-urban differences in cortical thickness (CT), and the association of regional CT with neighborhood disadvantage, using both clinically normal and impaired older adults.

Public Health.

Background: Stress is known to have a negative impact on hippocampal volume (HCV) and convey higher risk for development of Alzheimer's disease (AD). Previous research has established differences among older adults by racial/ethnic background in levels of stress (Brown, Mitchell, & Ailshire, 2020) and HCV (Bygrave et al., 2022).

Public Health.

Background: The Women's Alzheimer's Movement Prevention Center (WAMPC) at Cleveland Clinic evaluates women's risk factors for developing Alzheimer's disease and provides personalized recommendations for reducing risk. Previous research has established that up to 40% of Alzheimer's disease (AD) cases might be prevented when modifiable risk factors are addressed. To better understand individual risk profiles, a wealth of information is collected, including self-reported health conditions (both personal and familial), lifestyle factors (e.

Public Health.

Background: International collaboration is crucial to the future of research in dementia with Lewy bodies (DLB). Although it is hoped that a single global DLB cohort can be created through combination of data from the many longitudinal studies conducted internationally, a high likelihood of phenotypic heterogeneity may prohibit harmonisation and analysis of datasets. Our primary objective is to determine whether significant heterogeneity is observed in the sociodemographic and clinical characteristics of people with DLB globally.

Public Health.

Background: Over 2.5 million LGBTQIA+ (lesbian, gay, bisexual, transgender, queer, intersex, asexual or another sexual and/or gender minority identity) adults in the U.S.

Biomarkers.

Background: Synuclein Aggregate Assays (SAA) in cerebrospinal fluid (CSF) and in skin biopsy have been shown to successfully identify underlying synuclein (Lewy body) pathology in patients with Parkinson's disease. Data in Lewy Body Dementia (LBD) is limited, particularly with pathologic confirmation and staging of underlying Lewy body pathology, and other co-pathologies.

Method: Utilizing data and biofluids from participants in the U.

Biomarkers.

Background: In various neurological disorders, including Alzheimer's disease (AD) and AD-related dementia, there is a notable reduction in gamma-aminobutyric acid (GABA)ergic neurons, which represent the most abundant inhibitory neurons in the human brain. This study explores molecular association between miR-502-3p and the function of GABAergic neurons in AD.

Method: The investigation commenced by examining the status of GABA receptor proteins and miR-502-3p in postmortem AD brains.

Biomarkers.

Background: Although substantial literature supports sex differences in Alzheimer's disease (AD), many research samples comprise predominantly non-Hispanic white (NHW) participants, limiting generalizability. Work from our group in mainly-NHW cohorts suggests a female-specific time-limited resilience in cortical thickness (CT; Cieri et al., 2022) and possibly hippocampal volume in the presence of amyloid (ADNI: Caldwell et al.

Biomarkers.

Background: Inflammatory changes are a key element of Alzheimer's disease (AD)pathophysiology. However, there is lack of clarity regarding key gene drivers of the cytokines identified as playing a role in clinical AD progression and their relationship to AD biomarkers to understand their clinical role.

Method: We investigated transcriptomic datasets from Alzheimer's Disease Neuroimaging Initiative (ADNI) and Harvard Brain Tissue Resource Center (HBTRC) to evaluate regulatory gene networks in human AD.

Biomarkers.

Background: This study set to determine if 123I-ioflupane SPECT striatal binding ratio (SBR) correlated with parkinsonian symptoms measured on Movement Disorder Society - Unified Parkinson's Disease Rating Scale Part III (UPDRS-III) in a dementia with Lewy bodies (DLB) cohort and if SBR measured at baseline could predict progression of parkinsonian symptoms over 2 years.

Methods: This is a retrospective cohort study using the U.S.