236 results match your criteria: "Center for Movement Disorders and Neurorestoration[Affiliation]"
JAMA Neurol
December 2013
Department of Neurology, Neurological Institute of New York, Columbia University College of Physicians and Surgeons, New York, New York2University of Florida Center for Movement Disorders and Neurorestoration, Gainesville3Malcom Randall VA Medical Center, Gainesville, Florida.
Mov Disord
December 2013
University of Florida Center for Movement Disorders and Neurorestoration, Departments of Neurology and Neurosurgery, Gainesville, Florida.
Neurotherapeutics
January 2014
Center for Movement Disorders and Neurorestoration, Department of Neurology, University of Florida, 3450 Hull Road, Gainesville, FL, 32607, USA,
Surgical treatment for Parkinson's disease (PD) has evolved from ablative procedures, within a variety of brain regions, to implantation of electrodes into specific targets of the basal ganglia. Electrode implantation surgery, referred to as deep brain stimulation (DBS), is preferred to ablative procedures by many experts owing to its reversibility, programmability, and the ability to be safely performed bilaterally. Several randomized clinical studies have demonstrated the effectiveness of DBS surgery for control of PD symptoms.
View Article and Find Full Text PDFBackground: Deep brain stimulation (DBS) is a surgical treatment involving the implantation of a brain lead connected to a chest-based neurostimulator similar to a cardiac pacemaker. The device can be programmed to deliver electrical impulses to neuromodulate abnormal brain circuitry in disorders such as Parkinson's disease (PD), essential tremor (ET), and dystonia. As the number of patients receiving DBS surgery increases, it will be important for primary care doctors to identify reasonable DBS candidates for referral to an experienced center.
View Article and Find Full Text PDFRinsho Shinkeigaku
April 2014
Center for Movement Disorders and Neurorestoration, Departments of Neurology and Neurosurgery, University of Florida.
Deep brain stimulation (DBS) has become an important treatment option for carefully screened medication resistant neurological and neuropsychiatric disorders. DBS therapy is not always applied deep to the brain; does not have to be applied exclusively to the brain; and the mechanism for DBS is not simply stimulation of structures. The applications and target locations for DBS devices are rapidly expanding, with many new regions of the brain, spinal cord, peripheral nerves, and muscles now possibly accessed through this technology.
View Article and Find Full Text PDFFront Hum Neurosci
September 2013
1Center for Parkinson's Disease and Other Movement Disorders, Columbia University Medical Center NY, USA ; 2University of Florida Center for Movement Disorders and Neurorestoration, Gainesville FL, USA ; 3Malcom Randall VA Medical Center, Gainesville FL, USA.
Studies suggest that endogenous field effects may play a role in neuronal oscillations and communication. Non-invasive transcranial electrical stimulation with low-intensity currents can also have direct effects on the underlying cortex as well as distant network effects. While Parkinson's disease (PD) is amenable to invasive neuromodulation in the basal ganglia by deep brain stimulation (DBS), techniques of non-invasive neuromodulation like transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS) are being investigated as possible therapies.
View Article and Find Full Text PDFJ Biomech
October 2013
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, United States of America; Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL, United States of America.
Essential tremor (ET) is a common tremor disorder affecting postural/action tremor of the upper extremities and midline. Recent research revealed a cerebellar-like deficit during tandem gait in persons with ET, though spatiotemporal variability during normal gait in ET has been relatively ignored. The first purpose of this study was to investigate gait variability magnitude and structure in ET as compared to healthy older adults (HOA).
View Article and Find Full Text PDFClin Neurophysiol
February 2014
Department of Applied Physiology and Kinesiology, University of Florida, USA; Center for Movement Disorders and Neurorestoration, University of Florida, USA. Electronic address:
Objective: Locomotor adaptation enables safe, efficient navigation among changing environments. We investigated how healthy young (HYA) and older (HOA) adults and persons with Parkinson's disease (PD) adapt to walking on a split-belt treadmill, retain adapted gait parameters during re-adaptation, and store aftereffects to conventional treadmill walking.
Methods: Thirteen PD, fifteen HYA, and fifteen HOA walked on a split-belt treadmill for ten minutes with one leg twice as fast as the other.
Parkinsons Dis
July 2013
Department of Neurology, University of Florida Center for Movement Disorders and Neurorestoration, 3450 Hull Road, 4th Floor, Gainesville, FL 32607, USA.
In 1961, David C. Poskanzer and Robert S. Schwab presented a paper, "Studies in the epidemiology of Parkinson's disease predicting its disappearance as a major clinical entity by 1980.
View Article and Find Full Text PDFInt J Neurosci
December 2013
1Departments of Neurology and Neurosurgery, Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL , USA.
Parkin mutations are a common cause of early-onset Parkinson's disease. To study the clinical features and treatment responses of patients with homozygous or heterozygous Parkin mutations, we performed a retrospective chart review in six early-onset parkinsonism patients with pathogenic Parkin mutations. The clinical phenotypes observed in this cohort, all drawn from different families, were variable.
View Article and Find Full Text PDFNeuromodulation
October 2014
Department of Neurosurgery, University of Florida College of Medicine/Shands Hospital, Center for Movement Disorders and Neurorestoration, Gainesville, FL, USA.
Object: Despite numerous reports on the morbidity and mortality of deep brain stimulation (DBS), cerebral venous infarction has rarely been reported. We present four cases of venous infarct secondary to DBS surgery.
Methods: The diagnosis of venous infarction was based on 1) delayed onset of new neurologic deficits on postoperative day 1 or 2; 2) significant edema surrounding the superficial aspect of the implanted lead, with or without subcortical hemorrhage on CT scan.
Gait Posture
September 2013
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, United States; Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL, United States.
Gait initiation is a transitional task involving a voluntary shift from a static, stable position to a relatively less-stable state of locomotion. During gait initiation, anticipatory postural adjustments precede stepping in order to generate forward momentum while balance is maintained. While deficits in gait initiation are frequently reported for persons with Parkinson's disease, there is a paucity of information regarding gait initiation performance in persons with Essential Tremor.
View Article and Find Full Text PDFMov Disord
August 2013
Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL, USA.
Background: Many individuals with Parkinson's disease (PD) experience apathy independent of depression.
Methods: In this study, we examined hedonic and behavioral deficits related to apathy in 50 patients with PD and 42 healthy older adults who completed standardized measures.
Results: Regression analyses revealed that apathy was associated with anticipatory, but not consummatory, anhedonia and reduced goal-directed behavior, independent of PD diagnosis, age, education, and depressive symptoms.
J Neurol Neurosurg Psychiatry
September 2013
Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, USA.
Objective: Sensorimotor integration is impaired in patients with Parkinson's disease (PD). Short latency afferent inhibition (SAI) and long latency afferent inhibition (LAI) measured with transcranial magnetic stimulation (TMS) can be used to measure sensorimotor integration. Subthalamic nucleus (STN) deep brain stimulation (DBS) has been found to restore these abnormalities, but the time course of these changes is not known.
View Article and Find Full Text PDFJ Clin Neurosci
July 2013
Center for Movement Disorders and Neurorestoration, University of Florida College of Medicine, Gainesville, FL 32607, USA.
Painful legs moving toes (PLMT) is a rare disorder characterized by an often-severe painful sensation in the legs associated with involuntary movement of the toes. The treatment can be challenging given the poor response to pharmacotherapy. We present a patient with PLMT who obtained substantial benefit in both pain and severity of involuntary movement with botulinum toxin type A injections for more than 3 years.
View Article and Find Full Text PDFPLoS One
December 2013
Departments of Neurology and Neurosurgery, University of Florida Center for Movement Disorders and Neurorestoration, Gainesville, Florida, United States of America.
Objective: We aimed in this investigation to study deep brain stimulation (DBS) battery drain with special attention directed toward patient symptoms prior to and following battery replacement.
Background: Previously our group developed web-based calculators and smart phone applications to estimate DBS battery life (http://mdc.mbi.
Tremor Other Hyperkinet Mov (N Y)
July 2013
Department of Neurology, University of South Florida College of Medicine, Parkinson's Disease and Movement Disorders Center, Tampa, Florida, United States of America ; UF Center for Movement Disorders and Neurorestoration, Gainesville, Florida, United States of America.
Background: Deep brain stimulation (DBS) is an increasingly utilized therapeutic modality for the management of medication refractory essential tremor (ET). The aim of this study was to determine whether DBS allowed for anti-tremor medication reduction within the year after the procedure was performed.
Methods: We conducted a retrospective chart review and telephone interviews on 34 consecutive patients who had been diagnosed with ET, and who had undergone unilateral DBS surgery.
Nat Rev Neurol
February 2013
Center for Movement Disorders and Neurorestoration, Department of Neurology, University of Florida, College of Medicine, Gainesville, FL 32610, USA.
Research in movement disorders in 2012 has improved our understanding of the pathogenic mechanisms of disease and led to development of potential novel therapeutic approaches. Key advances were linked to mechanisms underlying spread of neurodegenerative pathology, immunotherapy, stem cells, genetics and deep brain stimulation in parkinsonism and related disorders.
View Article and Find Full Text PDFBMJ Open
December 2012
Department of Neurology, University of Florida Center for Movement Disorders and Neurorestoration, Gainesville, Florida, USA.
Objective: Sinemet, a combination drug containing carbidopa and levodopa is considered the gold standard therapy for the treatment of Parkinson's disease (PD). When approved by the Food and Drug Administration (FDA) in 1988, a maximum daily dosage limit of 800 mg (eight tablets) of the 25/100 carbidopa/levodopa formulation was introduced. Overall, the FDA approval was a historic success; however, the pill limit has been hardcoded into many online medical record systems.
View Article and Find Full Text PDFInt Rev Neurobiol
September 2013
Department of Neurology, Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, USA.
The use of neuromodulatory techniques in the treatment of neurological disorders is expanding and now includes devices targeting the motor cortex, basal ganglia, spinal cord, peripheral nervous system, and autonomic nervous system. In this chapter, we review and discuss the current and past literature as well as review indications for each of these devices in the ongoing management of many common neurological diseases including chronic pain, Parkinson's disease, tremor, dystonia, and epilepsy. We also discuss and update mechanisms of deep brain stimulation and electrical neuro-network modulation.
View Article and Find Full Text PDFLancet Neurol
December 2012
Department of Neurology, University of Florida Center for Movement Disorders and Neurorestoration, Gainesville, 32607, USA.
N Engl J Med
October 2012
Department of Neurology, University of Florida Center for Movement Disorders and Neurorestoration, Gainesville, USA.
JAMA Neurol
January 2013
Department of Neurology, University of Florida Center for Movement Disorders and Neurorestoration, Gainesville, FL, USA.
Objective: To collect the information necessary to design the methods and outcome variables for a larger trial of scheduled deep brain stimulation (DBS) for Tourette syndrome.
Design: We performed a small National Institutes of Health-sponsored clinical trials planning study of the safety and preliminary efficacy of implanted DBS in the bilateral centromedian thalamic region. The study used a cranially contained constant-current device and a scheduled, rather than the classic continuous, DBS paradigm.
J Neurol
February 2013
Department of Neurology, Center for Movement Disorders and Neurorestoration, Gainesville, FL 32611, USA.
It has been previously well established that the use of dopaminergic agents in Parkinson's disease may contribute to behavioral disturbances such as dopamine dysregulation syndrome (DDS), impulse control disorders (ICD), and punding. ICD and punding have been most commonly addressed by reducing dose or by discontinuing the use of a dopamine agonist. Treatment of DDS has proven more challenging, and to date there has been no standard approach.
View Article and Find Full Text PDFPLoS One
January 2013
Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, United States of America.
Background: Gait performance is widely evaluated to assess health status in older adult populations. While several investigators have presented normative values for spatiotemporal gait parameters drawn from older adult populations, the literature has been void of large-scale cohort studies, which are needed in order to provide quantitative, normative gait data in persons with Parkinson's disease. The aim of this investigation was to provide reference values for clinically important gait characteristics in a large sample of ambulatory persons with Parkinson's disease to aid both clinicians and researchers in their evaluations and treatments of gait impairment.
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