236 results match your criteria: "Center for Movement Disorders and Neurorestoration[Affiliation]"
Semin Neurol
April 2017
Human Motor Control Section, Medical Neurology Branch, NINDS, NIH, Bethesda, Maryland.
The motor symptoms of Parkinson's disease are not limited to the cardinal symptoms of bradykinesia, rigidity, and resting tremor, but also include a variety of interrelated motor phenomena such as deficits in spatiotemporal planning and movement sequencing, scaling and timing of movements, and intermuscular coordination that can be clinically observed. Although many of these phenomena overlap, a review of the full breadth of the motor phenomenon can aid in the diagnosis and monitoring of disease progression.
View Article and Find Full Text PDFSemin Neurol
April 2017
Department of Neurology, University of Florida, Center for Movement Disorders and Neurorestoration, Gainesville, Florida.
Neuromodulation
July 2017
Department of Neuroscience and Experimental Therapeutics, Albany Medical Center, Albany, NY, USA.
Objectives: Deep brain stimulation (DBS) is a well-established treatment for the management of severe motor fluctuations in advanced Parkinson's disease (PD). Until recently, device regulation, medical, and insurance practices limited DBS to patients with advanced stages of PD. In February 2016 this changed, however, when the US Food and Drug Administration (FDA) granted formal approval for the use of brain stimulator in mid-stage PD patients.
View Article and Find Full Text PDFJAMA Neurol
July 2017
Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville.
Front Neurol
April 2017
Clinical and Health Psychology, University of Florida, Gainesville, FL, USA.
Background: Analyses of subcortical gray structure volumes in non-demented idiopathic Parkinson's disease (PD) often, but not always, show volume loss of the putamen, caudate nucleus, nucleus accumbens, and hippocampus. There is building evidence that structure morphometry might be more sensitive to disease-related processes than volume.
Objective: To assess morphometric differences of subcortical structures (putamen, caudate nucleus, thalamus, globus pallidus, nucleus accumbens, and amygdala) as well as the hippocampus in non-demented individuals with PD relative to age and education matched non-PD peers.
J Neurol Neurosurg Psychiatry
July 2017
Institute of Neurogenetics, University of Luebeck, Luebeck, Germany.
Background: Depression and anxiety frequently accompany the motor manifestations of isolated adult-onset focal dystonias. Whether the body region affected when this type of dystonia first presents is associated with the severity of these neuropsychiatric symptoms is unknown.
Objectives: The aim of this study was to determine whether depression, anxiety and social anxiety vary by dystonia onset site and evaluate whether pain and dystonia severity account for any differences.
Parkinsonism Relat Disord
July 2017
Surgical Movement Disorders, Department of Neurology, University of California San Francisco and the San Francisco Veteran's Affairs Medical Center, 1635 Divisadero Street, 5th Floor, Suite 520-530, San Francisco, CA 94115, United States. Electronic address:
Introduction: This study of thalamic deep brain stimulation (DBS) investigated whether a novel constant-current device improves tremor and activities of daily living (ADL) in patients with essential tremor (ET).
Methods: A prospective, controlled, multicenter study was conducted at 12 academic centers. We investigated the safety and efficacy of unilateral and bilateral constant-current DBS of the ventralis intermedius (VIM) nucleus of the thalamus in patients with essential tremor whose tremor was inadequately controlled by medications.
Parkinsonism Relat Disord
June 2017
National Engineering Laboratory for Neuromodulation, Tsinghua University, Beijing, China; Precision Medicine & Healthcare Research Center, Tsinghua-Berkeley Shenzhen Institute, Shenzhen, China; Man-machine-environment Engineering Institute, School of Aerospace Engineering, Tsinghua University, Beijing, China; Center of Epilepsy, Beijing Institute for Brain Disorders, Beijing, China. Electronic address:
J Appl Physiol (1985)
July 2017
Department of Biobehavioral Sciences, Teachers College, Columbia University, New York, New York;
Cough is an airway-protective mechanism that serves to detect and forcefully eject aspirate material. Existing research has identified the ability of healthy young adults to suppress or modify cough motor output based on external cueing. However, no study has evaluated the ability of people with Parkinson's disease (PD) and healthy older adults (HOAs) to upregulate cough motor output.
View Article and Find Full Text PDFJ Neurol Sci
April 2017
Center for Movement Disorders and Neurorestoration, Department of Neurology, University of Florida, Gainesville, Florida, USA.
Neuroimage Clin
November 2017
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, FL, USA; Department of Neurology and Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL, USA; Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA.
Objective: A prior longitudinal study demonstrates that free-water diffusion magnetic resonance imaging (dMRI) tracks progression in the substantia nigra (Ofori et al., 2015b). Here, we test the acute effects of antiparkinsonian medication on this established imaging progression marker for the first time.
View Article and Find Full Text PDFJ Geriatr Psychiatry Neurol
January 2017
3 Center for Movement Disorders and Neurorestoration, McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
Background: Apathy, one of the most common neuropsychiatric symptoms in Parkinson's disease (PD), has been associated with reduced daily functioning, cognition, treatment compliance, quality of life, and increased caregiver burden and distress, among other outcomes.
Objectives: The purpose of the present study was to develop and gather pilot data on the feasibility, acceptability, and efficacy of the Parkinson's Active Living (PAL) program, to our knowledge, the first behavioral treatment specifically designed to target apathy in patients with PD. The Parkinson's Active Living is a primarily telephone-based, 6-week activity scheduling and monitoring intervention that incorporates external cueing to target disease-related self-generational deficits to reduce levels of apathy in nondemented, highly apathetic patients with PD.
J Headache Pain
December 2017
Department of Neuroscience, Norwegian University of Science and Technology (NTNU), Edvard Griegs Gate, NO-7491, Trondheim, Norway.
Background: The large geographical gaps in our knowledge of the prevalence and burden of headache disorders include almost all of Eastern Mediterranean Region (EMR). We report a nationwide population-based study in Pakistan, an EMR country with the sixth largest population in the world, conducted as a project within the Global Campaign against Headache.
Methods: We surveyed six locations from the four provinces of Pakistan: Punjab, Sindh, Khyber Pakhtunkhwa and Baluchistan.
Mov Disord
April 2017
Department of Neurology, Center for Movement Disorders and Neurorestoration, University of Florida, Department of Neurology, Gainesville, Florida, USA.
Background: Dystonia often has inconsistent benefits and requires more energy-demanding DBS settings. Studies suggest that squared biphasic pulses could provide significant clinical benefit; however, dystonia patients have not been explored.
Objectives: To assess safety and tolerability of square biphasic DBS in dystonia patients.
Hum Brain Mapp
April 2017
Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida.
The subthalamic nucleus (STN) and globus pallidus internus (GPi) have recently been shown to encode reward, but few studies have been performed in humans. We investigated STN and GPi encoding of reward and loss (i.e.
View Article and Find Full Text PDFBrain Cogn
April 2017
Department of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA; Center for Movement Disorders and Neurorestoration, University of Florida, Gainesville, FL, USA.
Persons with Parkinson's disease (PD) are typically more susceptible than healthy adults to impaired performance when two tasks (dual task interference) are performed simultaneously. This limitation has by many experts been attributed to limitations in cognitive resources. Nearly all studies of dual task performance in PD employ walking or balance-based motor tasks, which are commonly impaired in PD.
View Article and Find Full Text PDFFront Integr Neurosci
November 2016
Department of Neurology, Center for Movement Disorders and Neurorestoration, University of Florida Gainesville, FL, USA.
This paper provides an overview of current progress in the technological advances and the use of deep brain stimulation (DBS) to treat neurological and neuropsychiatric disorders, as presented by participants of the Fourth Annual DBS Think Tank, which was convened in March 2016 in conjunction with the Center for Movement Disorders and Neurorestoration at the University of Florida, Gainesveille FL, USA. The Think Tank discussions first focused on policy and advocacy in DBS research and clinical practice, formation of registries, and issues involving the use of DBS in the treatment of Tourette Syndrome. Next, advances in the use of neuroimaging and electrochemical markers to enhance DBS specificity were addressed.
View Article and Find Full Text PDFJAMA Neurol
January 2017
Department of Neurology, University of Florida College of Medicine, Gainesville.
Clin Neuropsychol
April 2017
a Department of Clinical and Health Psychology , University of Florida, Gainesville , FL , USA.
Objective: A 71-year-old (MN) with an 11-year history of left onset tremor diagnosed as Parkinson's disease (PD) completed longitudinal brain magnetic resonance imaging (MRI) and neuropsychological testing. MRI scans showed an asymmetric caudate nucleus (right < left volume). We describe this asymmetry at baseline and the progression over time relative to other subcortical gray, frontal white matter, and cortical gray matter regions of interest.
View Article and Find Full Text PDFInterdiscip Neurosurg
September 2016
Center for Movement Disorders and Neurorestoration, University of Florida, 3450 Hull Rd, Gainesville, FL 32607, USA.
There is no consensus regarding the effects of deep brain stimulation (DBS) surgery on swallowing outcomes in Parkinson's disease (PD). No prospective studies have compared airway protective outcomes following DBS to the subthalamic nucleus (STN) versus globus pallidus interna (GPi). A recent retrospective study described swallowing outcomes pre- and post-STN vs.
View Article and Find Full Text PDFMov Disord
March 2017
Department of Neurology, Center for Movement Disorders and Neurorestoration, University of Florida School, Gainesville, Florida, USA.
Objective: The aim of this study was to evaluate the neurobehavioral safety of constant-current subthalamic deep brain stimulation and to compare the neuropsychological effects of stimulation versus electrode placement alone.
Methods: A total of 136 patients with Parkinson's disease underwent bilateral subthalamic device implantation in this randomized trial. Patients received stimulation either immediately after device implantation (n = 101; active stimulation) or beginning 3 months after surgery (n = 35; delayed activation control).
Parkinsonism Relat Disord
December 2016
Department of Neurology, University Hospital Schleswig Holstein, Kiel, Germany.
Essential tremor (ET) is a common cause of significant disability, but its etiologies and pathogenesis are poorly understood. Research has been hampered by the variable definition of ET and by non-standardized research approaches. The National Institute of Neurological Disorders and Stroke (USA) invited experts in ET and related fields to discuss current knowledge, controversies, and gaps in our understanding of ET and to develop recommendations for future research.
View Article and Find Full Text PDFMov Disord Clin Pract
January 2016
University of Alabama at Birmingham, Department of Neurology; University of Alabama at Birmingham, Department of Biomedical Engineering.
Background: Deep brain stimulation is an effective treatment for movement disorders, but it is relatively complex, invasive, and costly. Little is known about whether stimulation mode alters pulse generator (battery) longevity in routine clinical care.
Objective: To compare battery longevity during monopolar versus bipolar stimulation in patients who underwent deep brain stimulation for movement disorders.
J Alzheimers Dis
September 2016
Memory and Alzheimer's Treatment Center & Alzheimer's Disease Research Center, Division of Geriatric Psychiatry and Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Background: Deep brain stimulation (DBS) is used to modulate the activity of dysfunctional brain circuits. The safety and efficacy of DBS in dementia is unknown.
Objective: To assess DBS of memory circuits as a treatment for patients with mild Alzheimer's disease (AD).