Piecing it together: atrophy profiles of hippocampal subfields relate to cognitive impairment along the Alzheimer's disease spectrum.

Introduction: People with Alzheimer's disease (AD) experience more rapid declines in their ability to form hippocampal-dependent memories than cognitively normal healthy adults. Degeneration of the whole hippocampal formation has previously been found to covary with declines in learning and memory, but the associations between subfield-specific hippocampal neurodegeneration and cognitive impairments are not well characterized in AD. To improve prognostic procedures, it is critical to establish in which hippocampal subfields atrophy relates to domain-specific cognitive declines among people along the AD spectrum.

Adolescents' hair cortisol concentrations during COVID-19: Evidence from two longitudinal studies in the Netherlands and the United States.

Background: Prolonged stress exposure is associated with alterations in cortisol output. The COVID-19 pandemic represented a stressor for many, including children. However, a high-quality caregiving environment may protect against psychological problems and possibly against elevations in cortisol.

The dimensionality of perceptual anomalies and their relationships with bullying victimization among Chinese adolescents: From a network perspective.

Anomalous perceptual experiences in adolescents are common and may predict future psychotic disorders and other psychopathologies. However, the underlying structure and their specific relationships with bullying victimizations, a typical stressor for adolescents, remain unclear. Therefore, the current study aimed to clarify the structure of perceptual anomalies as assessed by the Cardiff Anomalous Perceptions Scale (CAPS) using exploratory graph analysis (EGA), a new factor retention method based on network psychometrics.

Hooked on a thought: Associations between rumination and neural responses to social rejection in adolescent girls.

Rumination is a significant risk factor for psychopathology in adolescent girls and is associated with heightened and prolonged physiological arousal following social rejection. However, no study has examined how rumination relates to neural responses to social rejection in adolescent girls; thus, the current study aimed to address this gap. Adolescent girls (N = 116; ages 16.

Task-adaptive changes to the target template in response to distractor context: Separability versus similarity.

Theories of attention hypothesize the existence of an attentional template that contains target features in working or long-term memory. It is frequently assumed that the template contains a veridical copy of the target, but recent studies suggest that this is not true when the distractors are linearly separable from the target. In such cases, target representations shift "off-veridical" in response to the distractor context, presumably because doing so is adaptive and increases the representational distinctiveness of targets from distractors.

Decoding fMRI data with support vector machines and deep neural networks.

Background: Multivoxel pattern analysis (MVPA) examines fMRI activation patterns associated with different cognitive conditions. Support vector machines (SVMs) are the predominant method in MVPA. While SVM is intuitive and easy to apply, it is mainly suitable for analyzing data that are linearly separable.

A Transdiagnostic Study of Effort-Cost Decision-Making in Psychotic and Mood Disorders.

Background: Research suggests that effort-cost decision-making (ECDM), the estimation of work required to obtain reward, may be a relevant framework for understanding motivational impairment in psychotic and mood pathology. Specifically, research has suggested that people with psychotic and mood pathology experience effort as more costly than controls, and thus pursue effortful goals less frequently. This study examined ECDM across psychotic and mood pathology.

Learned associations serve as target proxies during difficult but not easy visual search.

The target template contains information in memory that is used to guide attention during visual search and is typically thought of as containing features of the actual target object. However, when targets are hard to find, it is advantageous to use other information in the visual environment that is predictive of the target's location to help guide attention. The purpose of these studies was to test if newly learned associations between face and scene category images lead observers to use scene information as a proxy for the face target.

Prefrontal Cortex Codes Representations of Target Identity and Feature Uncertainty.

Many objects in the real world have features that vary over time, creating uncertainty in how they will look in the future. This uncertainty makes statistical knowledge about the likelihood of features critical to attention demanding processes such as visual search. However, little is known about how the uncertainty of visual features is integrated into predictions about search targets in the brain.

Dehydroepiandrosterone mediates associations between trauma-related symptoms and anterior pituitary volume in children and adolescents.

Introduction: The anterior pituitary gland (PG) is a potential locus of hypothalamic-pituitary-adrenal (HPA) axis responsivity to early life stress, with documented associations between dehydroepiandrosterone (DHEA) levels and anterior PG volumes. In adults, elevated anxiety/depressive symptoms are related to diminished DHEA levels, and studies have shown a positive relationship between DHEA and anterior pituitary volumes. However, specific links between responses to stress, DHEA levels, and anterior pituitary volume have not been established in developmental samples.

Updates to the Autism Intervention Research Network on Physical Health (AIR-P) Research Agenda.

Introduction: Autistic individuals, now representing one in 36 individuals in the U.S., experience disproportionate physical health challenges relative to non-autistic individuals.

Insight and Recommendations for Fragile X-Premutation-Associated Conditions from the Fifth International Conference on Premutation.

The premutation of the fragile X messenger ribonucleoprotein 1 () gene is characterized by an expansion of the CGG trinucleotide repeats (55 to 200 CGGs) in the 5' untranslated region and increased levels of mRNA. Molecular mechanisms leading to fragile X-premutation-associated conditions (FXPAC) include cotranscriptional R-loop formations, mRNA toxicity through both RNA gelation into nuclear foci and sequestration of various CGG-repeat-binding proteins, and the repeat-associated non-AUG (RAN)-initiated translation of potentially toxic proteins. Such molecular mechanisms contribute to subsequent consequences, including mitochondrial dysfunction and neuronal death.

Cognitive maps: Constructing a route with your snout.

Humans construct cognitive maps of the physical, imagined, and abstract world around us based on visually sampled information. A new study shows how the human brain can also use olfactory cues to form and use cognitive maps.

Partner similarity and social cognitive traits predict social interaction success among strangers.

Social interactions are a ubiquitous part of engaging in the world around us, and determining what makes an interaction successful is necessary for social well-being. This study examined the separate contributions of individual social cognitive ability and partner similarity to social interaction success among strangers, measured by a cooperative communication task and self-reported interaction quality. Sixty participants engaged in a 1-h virtual social interaction with an unfamiliar partner (a laboratory confederate) including a 30-min cooperative 'mind-reading' game and then completed several individual tasks and surveys.

A Longitudinal Study of Executive Function in Daily Life in Male Fragile X Premutation Carriers and Association with FXTAS Conversion.

Background: Men with fragile X-associated tremor/ataxia syndrome (FXTAS) often develop executive dysfunction, characterized by disinhibition, frontal dyscontrol of movement, and working memory and attention changes. Although cross-sectional studies have suggested that earlier executive function changes may precede FXTAS, the lack of longitudinal studies have made it difficult to address this hypothesis.

Methods: This study included 66 premutation carriers (PC) ranging from 40-78 years (Mean=59.

The INSAR Community Collaborator Request: Using community-academic partnerships to enhance outcomes of participatory autism research.

Participatory approaches, in which researchers work together with members of the autism community (e.g., autistic people, family members, caregivers, or other stakeholders) to design, conduct, and disseminate research, have become increasingly prominent within the field of autism research over the past decade.

Habituation of auditory responses in young autistic and neurotypical children.

Prior studies suggest that habituation of sensory responses is reduced in autism and that diminished habituation could be related to atypical autistic sensory experiences, for example, by causing brain responses to aversive stimuli to remain strong over time instead of being suppressed. While many prior studies exploring habituation in autism have repeatedly presented identical stimuli, other studies suggest group differences can still be observed in habituation to intermittent stimuli. The present study explored habituation of electrophysiological responses to auditory complex tones of varying intensities (50-80 dB SPL), presented passively in an interleaved manner, in a well-characterized sample of 127 autistic (M  = 65.

Seeking versus receiving help: How children integrate suggestions in memory decisions.

The current research examined how seeking versus receiving help affected children's memory and confidence decisions. Baseline performance, when no help was available, was compared to performance when help could be sought (Experiment 1: N = 83, 41 females) or was provided (Experiment 2: N = 84, 44 females) in a sample of predominately White 5-, 7-, and 9-year-olds from Northern California. Data collection occurred from 2018 to 2019.

Decision and response monitoring during working memory are sequentially represented in the human insula.

Emerging research supports a role of the insula in human cognition. Here, we used intracranial EEG to investigate the spatiotemporal dynamics in the insula during a verbal working memory (vWM) task. We found robust effects for theta, beta, and high frequency activity (HFA) during probe presentation requiring a decision.

Examining infants' visual paired comparison performance in the US and rural Malawi.

Measures of attention and memory were evaluated in 6- to 9-month-old infants from two diverse contexts. One sample consisted of African infants residing in rural Malawi (N = 228, 118 girls, 110 boys). The other sample consisted of racially diverse infants residing in suburban California (N = 48, 24 girls, 24 boys).

A Novel Approach to Assessing Infant and Child Mental Rotation.

Mental rotation is a critically important, early developing spatial skill that is related to other spatial cognitive abilities. Understanding the early development of this skill, however, requires a developmentally appropriate assessment that can be used with infants, toddlers, and young children. We present here a new eye-tracking task that uses a staircase procedure to assess mental rotation in 12-, 24-, and 36-month-old children (N = 41).

Is covert attention necessary for programming accurate saccades? Evidence from saccade-locked event-related potentials.

For decades, researchers have assumed that shifts of covert attention mandatorily occur prior to eye movements to improve perceptual processing of objects before they are fixated. However, recent research suggests that the N2pc component-a neural measure of covert attentional allocation-does not always precede eye movements. The current study investigated whether the N2pc component mandatorily precedes eye movements and assessed its role in the accuracy of gaze control.