124 results match your criteria: "Center for Limb Loss and Mobility[Affiliation]"

Fracture site motion is thought to play an important role in the healing of complex fractures of the distal femur via mechanotransduction. Measuring this motion in vivo is challenging, and this has led researchers to turn to finite element modeling approaches to gain insights into the mechanical environment at the fracture site. Developing a systematic understanding of the effect of different model choices for distal femur fractures may allow more accurate prediction of fracture site motion from these types of simulations.

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Should individuals with unilateral transtibial amputation carry a load on their intact or prosthetic side?

J Biomech

December 2024

Department of Veterans Affairs Center for Limb Loss and MoBility, 1660 S. Columbian Way, Seattle, WA 98108, USA; Department of Mechanical Engineering, University of Washington, 3900 East Stevens Way NE, Seattle, WA 98195, USA. Electronic address:

Carrying side loads often occurs during activities of daily living. As walking is most unstable mediolaterally, side load carriage may further compromise gait biomechanics, especially for transtibial amputees (TTAs). This study investigated the effects of side load carriage on gait kinetics during steady-state walking to determine which side, intact or prosthetic, TTAs should carry a load.

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Individuals with transtibial amputation (TTA) experience altered gait mechanics, which are primarily attributed to the functional loss of the ankle plantarflexors. The plantarflexors contribute to body support and propulsion and play an important role in adapting to different load carriage conditions. However, how muscle function is altered across different prosthetic foot types and load carriage scenarios for individuals with TTA remains unclear.

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An overhead throwing motion is a common gross motor skill often taught in early childhood to improve physical activity participation. Yet, research investigating motor efficiency in overhead throws often focuses on improving performance in trained individuals. This project compares kinematic sequencing between trained and untrained youth.

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The effect of prosthetic foot stiffness category on intact limb knee loading associated with osteoarthritis in people with transtibial amputation.

J Biomech

November 2024

Center for Limb Loss and MoBility, VA Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA; Department of Rehabilitation Medicine, University of Washington, 1959 NE Pacific Street, Box 356490, Seattle, WA 98195, USA. Electronic address:

Lower limb prosthesis users are at an increased risk of developing osteoarthritis in their intact knee. There is a scarcity of literature examining how the stiffness properties of commercially available prosthetic feet impact gait mechanics, including knee loading biomechanical variables that have been associated with the development of osteoarthritis. This study aimed to isolate the effect of commercial prosthetic foot stiffness on intact knee loading, prosthetic foot-ankle biomechanics, and user perception.

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Article Synopsis
  • Research on lower limb amputations often focuses on general patient outcomes rather than individual experiences, highlighting a shift towards personalized rehabilitation.
  • The article emphasizes two main points: the need for predicting specific patient outcomes to inform amputation and prosthetic decisions, and the role of prediction models in creating decision support tools for shared decision-making.
  • Examples of these tools are provided, showcasing how they can help align medical decisions with individual patient priorities and preferences.
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People with transtibial limb loss frequently experience suboptimal gait outcomes. This is partly attributable to the absence of the biarticular gastrocnemius muscle, which plays a unique role in walking. Although a recent surge of biarticular prostheses aims to restore gastrocnemius function, the broad design space and lack of consensus on optimal hardware and control strategies present scientific and engineering challenges.

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The ankle infrequently develops primary osteoarthritis (OA), especially when compared to the hip and the knee. Ankle OA instead generally develops only after trauma. The consequences of end-stage ankle OA can nonetheless be extremely debilitating, with impairment comparable to that of end-stage kidney disease or congestive heart failure.

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Ability of a multi-segment foot model to measure kinematic differences in cavus, neutrally aligned, asymptomatic planus, and symptomatic planus foot types.

Gait Posture

September 2024

VA RR&D Center for Limb Loss and MoBility (CLiMB), Seattle, WA, United States; Department of Mechanical Engineering, University of Washington, Seattle, WA, United States; Department of Orthopaedics & Sports Medicine, University of Washington, Seattle, WA, United States. Electronic address:

Article Synopsis
  • * Three independent raters analyzed subjects' foot movements over multiple days while employing a four-segment foot model and performed statistical analysis to evaluate variability and differences by foot type during the stance phase of gait.
  • * Findings indicated that while static measures showed significant differences among foot types, the MFM's ability to detect dynamic differences was limited, particularly with respect to certain movements like the hallux to forefoot range of motion; thus, its sensitivity for identifying variations between pathologic and non-pathologic foot
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Background: Non-Hispanic Black (NHB) individuals have higher rates of amputation and increased risk of a transfemoral amputation due to dysvascular disease than non-Hispanic White (NHW) individuals. However, it is unclear if NHB individuals have differences in prosthesis use or functional outcomes following an amputation.

Objective: To determine if there are racial disparities in prosthesis abandonment and mobility outcomes in veterans who have undergone their first major unilateral lower extremity amputation (LEA) due to diabetes and/or peripheral artery disease.

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Development of the AMPDECIDE Decision Aid to Facilitate Shared Decision Making in Patients Facing Amputation Secondary to Chronic Limb Threatening Ischemia.

J Surg Res

July 2024

Department of Rehabilitation Medicine, University of Washington, Seattle, Washington; CLiMB - Center for Limb Loss and Mobility, Seattle VA Medical Center, Seattle, Washington; VA Puget Sound Health Care System, Seattle, Washington.

Introduction: We developed a patient decision aid to enhance patient participation in amputation level decision making when there is a choice between a transmetatarsal or transtibial amputation.

Methods: In accordance with International Patient Decision Aid Standards, we developed an amputation level patient decision aid for patients who are being considered for either a transmetatarsal or transtibial amputation, incorporating qualitative literature data, quantitative literature data, qualitative provider and patient interviews, expert panel input and iterative patient feedback.

Results: The rapid qualitative literature review and qualitative interviews identified five domains outcome priority domains important to patients facing amputation secondary to chronic limb threatening ischemia: 1) the ability to walk, 2) healing and risk for reamputation, 3) rehabilitation program intensity, 4) ease of prosthetic use, and 5) limb length after amputation.

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Background: Ankle-foot orthoses (AFOs) are commonly used to overcome mobility limitations related to lower limb musculoskeletal injury. Despite a multitude of AFOs to choose from, there is scant evidence to guide AFO prescription and limited opportunities for AFO users to provide experiential input during the process. To address these limitations in the current prescription process, this study evaluates a novel, user-centered and personalized 'test-drive' strategy using a robotic exoskeleton ('AFO emulator') to emulate commercial AFO mechanical properties (i.

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A method for automated masking and plantar pressure analysis using segmented computed tomography scans.

Gait Posture

June 2024

VA RR& D Center for Limb Loss and MoBility (CLiMB), Seattle, WA 98108, USA; Department of Mechanical Engineering, University of Washington, Seattle, WA 98195, USA; Department of Orthopaedics & Sports Medicine, University of Washington, Seattle, WA 98195, USA. Electronic address:

Background: Plantar pressure, a common gait and foot biomechanics measurement, is typically analyzed using proprietary commercial software packages. Regional plantar pressure analysis is often reported in terms of underlying bony geometry, and recent advances in image processing and accessibility have made computed tomography, radiographs, magnetic resonance imaging, or other imaging methods more popular for incorporating bone analyses in biomechanics.

Research Question: Can a computed tomography-based regional mask provide comparable regional analysis to commercial plantar pressure software and can the increased flexibility of an in-house method obtain additional insight from common measurements?

Methods: A plantar pressure analysis method was developed based on bony geometry from computed tomography scans to calculate peak pressure, pressure time integral incorporating sub-peak values, force time integral, pressure gradient, and pressure gradient angle.

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Introduction: The intact foot and ankle comprise a complex set of joints that allow rotation in multiple planes of motion. Some of these motions are coupled, meaning rotation in one plane induces motion in another. One such coupling is between the sagittal and transverse planes.

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The human health consequences of climate change and extreme weather events are well documented. Published literature details the unique effects and necessary adaptation planning for people with physical disabilities in general; however, the specific impacts and plans for people with limb loss have yet to be explored. In this article, we discuss the impacts related to threats due to heat, cold, severe storms, and power outages.

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The Effect of Prosthetic Limb Sophistication and Amputation Level on Self-reported Mobility and Satisfaction With Mobility.

Arch Phys Med Rehabil

July 2024

VA Puget Sound Health Care System, Seattle, WA; VA Center for Limb Loss and MoBility (CLiMB), Seattle, WA; Department of Rehabilitation Medicine, University of Washington, Seattle, WA.

Objective: To determine if lower limb prosthesis (LLP) sophistication is associated with patient-reported mobility and/or mobility satisfaction, and if these associations differ by amputation level.

Design: Cohort study that identified participants through a large national database and prospectively collected self-reported patient outcomes.

Setting: The Veterans Administration (VA) Corporate Data Warehouse, the National Prosthetics Patient Database, participant mailings, and phone calls.

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This article describes a novel approach to the control of a powered knee prosthesis where the control system provides passive behavior for most activities and then provides powered assistance only for those activities that require them. The control approach presented here is based on the categorization of knee joint function during activities into four behaviors: resistive stance behavior, active stance behavior, ballistic swing, and non-ballistic swing. The approach is further premised on the assumption that healthy non-perturbed swing-phase is characterized by a ballistic swing motion, and therefore, a replacement of that function should be similarly ballistic.

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Subject-specific material properties of the heel pad: An inverse finite element analysis.

J Biomech

March 2024

Center for Limb Loss and MoBility (CLiMB), Department of Veterans Affairs, Seattle, WA, USA; Departments of Mechanical Engineering, University of Washington, Seattle, WA, USA; Orthopaedics & Sports Medicine, University of Washington, Seattle, WA, USA. Electronic address:

Individuals with diabetes are at a higher risk of developing foot ulcers. To better understand internal soft tissue loading and potential treatment options, subject-specific finite element (FE) foot models have been used. However, existing models typically lack subject-specific soft tissue material properties and only utilize subject-specific anatomy.

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Talonavicular (TN) fusion is a common treatment for TN arthritis or deformity correction. There is incongruous evidence regarding remaining motion at the talocalcaneal and calcaneocuboid joints after TN fusion. Additionally, the effects of a malaligned TN fusion are not well understood and alignment of the fusion may be important for overall foot integrity.

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Transfemoral limb loss modestly increases the metabolic cost of optimal control simulations of walking.

PeerJ

January 2024

Military Operational Medicine Research Program, Fort Detrick, MD, United States of America.

Background: In transtibial limb loss, computer simulations suggest that the maintenance of muscle strength between pre- and post-limb loss can maintain the pre-limb loss metabolic cost. These results are consistent with comparable costs found experimentally in select cases of high functioning military service members with transtibial limb loss. It is unlikely that similar results would be found with transfemoral limb loss, although the theoretical limits are not known.

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Exploring the mechanical properties of 3D-printed multilayer lattice structures for use in accommodative insoles.

J Mech Behav Biomed Mater

February 2024

VA RR&D Center for Limb Loss and MoBility (CLiMB), VA Puget Sound Health Care System, 1660 S Columbian Way, MS 151, Seattle, WA, 98108, USA; Department of Mechanical Engineering, University of Washington, 3900 E Stevens Way NE, Box 352600, Seattle, WA, 98195, USA. Electronic address:

Full-contact insoles fabricated from multilayer foams are the standard of care (SoC) for offloading and redistributing high plantar pressures in individuals with diabetes at risk of plantar ulceration and subsequent lower limb amputation. These devices have regional variations in total thickness and layer thickness to create conformity with a patient's foot. Recent work has demonstrated that metamaterials can be tuned to match the mechanical properties of SoC insole foams.

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Article Synopsis
  • This study investigates how users of lower limb prostheses manage their cognitive efforts when focusing on their prostheses in daily life.
  • Focus groups were utilized to gather qualitative data from thirty participants, leading to thematic analysis of their shared experiences.
  • Key findings indicate that the attention to prostheses varies throughout the day and over time, suggesting that understanding this attention can help improve prosthetic technology and user experience.
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Background: Total ankle arthroplasty (TAA) continues to be investigated as a primary treatment for end-stage ankle arthritis. The objective of this study is to report mid- to long-term results of the Salto Talaris TAA using prospectively collected patient-reported outcomes and implant survival rates with 4- to 13-year follow-up.

Methods: This was a retrospective study of prospectively collected data from 2 multicenter cohort studies from 3 centers.

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Significant health disparities have been described for American Indian and Alaska Native (AIAN) patients undergoing various surgical procedures, however, research into healthcare segregation within orthopedic surgery has been limited. In this study, our purpose was to assess if AIAN patients were more likely to be treated by lower-volume surgeons and at lower-volume hospitals. AIAN and White patients who underwent one of four common orthopedic procedures (knee or hip arthroplasty, femur or tibia repair) were identified from a Washington state inpatient database.

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