[Application of Nano-drug Delivery Technology in Overcoming Drug Resistance in Lung Cancer].

Lung cancer is one of the most malignant tumor, representing a significant threat to human health. In China, its mortality rate is the highest among all malignant tumors. The occurrence of drug resistance has resulted in unfavourable prognosis for patients with lung cancer, and overcoming drug resistance is a significant challenge that needs to be addressed.

Nano-polymeric platinum activates PAR2 gene editing to suppress tumor metastasis.

Metastasis as the hallmark of cancer preferentially contributes to tumor recurrence and therapy resistance, aggrandizing the lethality of patients with cancer. Despite their robust suppressions of tumor progression, chemotherapeutics failed to attenuate cancer cell migration and even triggered pro-metastatic effects. In parallel, protease-activated receptor 2 (PAR2), a member of the G protein-coupled receptor subfamily, actively participates in cancer metastasis via multiple signal transduction pathways.

Nano-TiO impairs the health of crabs Charybdis japonica under warming conditions through waterborne and dietary exposures.

The widespread use of nano titanium dioxide (nano-TiO₂) poses ecological risks to marine ecosystems, especially when combined with ocean warming. However, most previous studies have only examined water-related exposures, leaving a gap in research on the impact of food transfer on organisms. In this work, the harmful impacts of nano-TiO on the Japanese swimming crab Charybdis japonica were studied through three scenarios: direct exposure (DE) of the crabs to warming and nano-TiO, indirect exposure (IE) via consumption of thick-shelled mussels Mytilus coruscus exposed to the same conditions, and combined exposure (CE), where crabs were directly subjected to warming and nano-TiO while feeding affected mussels.

Rational Design of Dual-Targeted Nanomedicines for Enhanced Vascular Permeability in Low-Permeability Tumors.

Designing dual-targeted nanomedicines to enhance tumor delivery efficacy is a complex challenge, largely due to the barrier posed by blood vessels during systemic delivery. Effective transport across endothelial cells is, therefore, a critical topic of study. Herein, we present a synthetic biology-based approach to engineer dual-targeted ferritin nanocages (Dt-FTn) for understanding receptor-mediated transport across tumor endothelial cells.

Biological and environmental degradation of two-dimensional materials.

As the use of two-dimensional materials continues to grow, so too does the need to understand the environmental and biological impact of such materials. Degradation is a critical step in the life cycle of any material, but the majority of such knowledge is obtained from test tube and in vitro studies. Therefore, there remains a gap in understanding the degradability of two-dimensional materials in complex systems (in vivo) and in different ambient environments.

An experimental and modelling approach to proclaim sustainable machining using avocado oil-based nano-cutting fluids.

Higher-end science and technology facilitate the human community with a sophisticated life despite it curses by abundant pollution. The alarming demand for sustainability pressurizes the manufacturing sector to ensure sustainable manufacturing. Since Molybdenum di sulfide (MoS) and avocado oil are known solid and liquid lubricants respectively, hence, it is a worthwhile attempt to implement the bio-based degradable avocado oil enriched with nano Molybdenum di sulfide (nMoS) particles as a potential machining fluid for CNC-end milling.

Optically Decoupling Electrochromic Dynamics and Morphological Evolution of a Single Soft Polyaniline Nanoentity.

Electroresponsive multicolored materials have tremendous potential in flexible electronics and smart wearable devices. Herein, the electrochromic dynamics and morphological evolution of a single soft polyaniline nanoentity can be visualized and decoupled by an opto-electrochemical imaging strategy. The durability, tinting speed, and reversibility down to the single-nanoparticle level are quantified, and the switching of transient intermediate electrochromic states is trapped.

Voices of Nanomedicine: Blueprint Guidelines for Collaboration in Addressing Global Unmet Medical Needs.

The "" under this Perspective underline the importance of interdisciplinary collaboration and partnerships across several disciplines, such as medical science and technology, medicine, bioengineering, and computational approaches, in bridging the gap between research, manufacturing, and clinical applications. Effective communication is key to bridging team gaps, enhancing trust, and resolving conflicts, thereby fostering teamwork and individual growth toward shared goals. Drawing from the success of the COVID-19 vaccine development, we advocate the application of similar collaborative models in other complex health areas such as nanomedicine and biomedical engineering.

Patterning Planar, Flexible Li-S Battery Full Cells on Laser-Induced Graphene Traces.

Laser conversion of commercial polymers to laser-induced graphene (LIG) using inexpensive and accessible CO lasers has enabled the rapid prototyping of promising electronic and electrochemical devices. Frequently used to pattern interdigitated supercapacitors, few approaches have been developed to pattern batteries-in particular, full cells. Herein, we report an LIG-based approach to a planar, interdigitated Li-S battery.

In Vitro Selection of Collagen-Binding Vascular Endothelial Growth Factor Containing Genetically Encoded Mussel-Inspired Adhesive Amino Acids.

Protein immobilization technology is important in medical and industrial applications. We previously reported all-in-one in vitro selection, wherein a collagen-binding vascular endothelial growth factor (CB-VEGF) was identified from a fusion library of random and VEGF sequences. However, its interaction chemistry is mainly limited to the interaction established by the 20 canonical amino acids.

Enhanced Osteoporosis Treatment via Nano Drug Coating Encapsulating GG.

Osteoporosis is the most common systemic skeletal disorder, particularly associated with aging and postmenopausal women. With the growing knowledge about the gut-bone axis, the therapeutic strategies for osteoporosis have been shifted toward regulating gut microbiota to promote positive bone metabolism. Although GG (LGG) is widely reported to positively regulate bone metabolism by restoring the dysbiotic microbiome, oral administration is associated with sensitivity to gastric fluid and low bioavailability.

Surface S-Doped Nanostructured RuO and Its Anion Passivating Effect for Efficient Overall Seawater Splitting.

Electrolysis of seawater for hydrogen (H) production to harvest clean energy is an appealing approach. In this context, there is an urgent need for catalysts with high activity and durability. RuO electrocatalysts have shown efficient activity in the hydrogen and oxygen evolution reactions (HER and OER), but they still suffer from poor stability.

Bioadhesives and bioactive hydrogels for wound management.

Delayed wound healing remains a major challenge in biomedical research, often leading to complications such as scarring, acute trauma, and chronic diseases. Effective wound management is crucial for enhancing treatment outcomes, preventing complications, and promoting tissue regeneration. In response to this need, a variety of polymeric biomaterials have been developed.

Genipin crosslinked sodium caseinate-chitosan oligosaccharide nanoparticles for optimizing β-carotene stability and bioavailability.

In this study, genipin served as crosslinker to combine sodium caseinate (SC) and chitosan oligosaccharide (COS), aiming to improve the physicochemical properties and encapsulation efficiency of SC in delivering hydrophobic nutritional factors. The genipin crosslinked complex of SC and COS (GSCC) was characterized by circular dichroism spectrum and infrared spectrum analyses. Nanoparticles produced from GSCC (GSCCNP) exhibited a superior hydrophilicity compared to those derived from SC (SCNP).

Insights into Interlayer Dislocation Augmented Zinc-Ion Storage Kinetics in MoS Nanosheets for Rocking-Chair Zinc-Ion Batteries with Ultralong Cycle-Life.

Increasing attention to sustainability and cost-effectiveness in energy storage sector has catalyzed the rise of rechargeable Zinc-ion batteries (ZIBs). However, finding replacement for limited cycle-life Zn-anode is a major challenge. Molybdenum disulfide (MoS), an insertion-type 2D layered material, has shown promising characteristics as a ZIB anode.

RNA control of reverse transcription in a diversity-generating retroelement.

Diversity-generating retroelements (DGRs) create massive protein sequence variation (up to 10) in ecologically diverse microorganisms. A recent survey identified around 31,000 DGRs from more than 1,500 bacterial and archaeal genera, constituting more than 90 environment types. DGRs are especially enriched in the human gut microbiome and nano-sized microorganisms that seem to comprise most microbial life and maintain DGRs despite reduced genomes.

AFM observation of protein translocation mediated by one unit of SecYEG-SecA complex.

Protein translocation across cellular membranes is an essential and nano-scale dynamic process. In the bacterial cytoplasmic membrane, the core proteins in this process are a membrane protein complex, SecYEG, corresponding to the eukaryotic Sec61 complex, and a cytoplasmic protein, SecA ATPase. Despite more than three decades of extensive research on Sec proteins, from genetic experiments to cutting-edge single-molecule analyses, no study has visually demonstrated protein translocation.

Evaluation of minced beef quality fortified with edible microalgae species during cryogenic storage.

The aim of this study is to evaluate the effect of some microalgae species adding with different forms on minced beef meat shelf life during cryogenic storage for 13 days. Chlorella vulgaris and Arthrospira platensis are chosen because of their safety and high nutritional value. Microalgae nanoparticles with their different forms have been prepared by using emulsification solvent evaporation method.

Artificially tagging tumors with nano-aluminum adjuvant-tethered antigen mRNA recruits and activates antigen-specific cytotoxic T cells for enhanced cancer immunotherapy.

T cell therapy for solid tumors faces significant challenges due to the immune off-target attack caused by the loss of tumor surface antigens and inactivation in acidic tumor microenvironment (TME). Herein, we developed a bifunctional immunomodulator (MO@NAL) by loading ovalbumin (OVA; model antigen) mRNA (mOVA) onto lysozyme-coated layered double hydroxide nano-aluminum adjuvant (NA). The NA's inherent alkalinity effectively neutralizes the excess acid within the TME and suppresses regulatory T cells, creating a favorable microenvironment to enhance cytotoxic T cell infiltration and activation in tumors.

Riveting Nucleation Enabled Long Cycling Life Calcium Metal Anodes.

Calcium metal batteries with high capacity and low cost are promising alternatives to Li-ion batteries for large-scale energy storage. However, its development is crucially impeded by the irreversible Ca metal anode, which is highly associated with uncontrollable Ca plating/stripping. Here, we report a new riveting strategy to regulate the nucleation and growth of a Ca metal anode in the 3D structure of a carbon nanotube film (CNF) by introducing in situ-formed Na metal mediators.

Lattice-guided growth of dense arrays of aligned transition metal dichalcogenide nanoribbons with high catalytic reactivity.

Transition metal dichalcogenides (TMDs) exhibit unique properties and potential applications when reduced to one-dimensional (1D) nanoribbons (NRs), owing to quantum confinement and high edge densities. However, effective growth methods for self-aligned TMD NRs are still lacking. We demonstrate a versatile approach for lattice-guided growth of dense, aligned MoS NR arrays via chemical vapor deposition (CVD) on anisotropic sapphire substrates, without tailored surface steps.

Bio-Orchestration of Cellular Organization and Human-Preferred Sensory Texture in Cultured Meat.

For cultured meat to effectively replace traditional meat, it is essential to develop scaffolds that replicate key attributes of real meat, such as taste, nutrition, flavor, and texture. However, one of the significant challenges in replicating meat characteristics with scaffolds lies in the considerable gap between the stiffness preferred by cells and the textural properties desired by humans. To address this issue, we focused on the microscale environment conducive to cell growth and the macro-scale properties favored by humans.

Machine Learning-Assisted High-Donor-Number Electrolyte Additive Screening toward Construction of Dendrite-Free Aqueous Zinc-Ion Batteries.

The utilization of electrolyte additives has been regarded as an efficient strategy to construct dendrite-free aqueous zinc-ion batteries (AZIBs). However, the blurry screening criteria and time-consuming experimental tests inevitably restrict the application prospect of the electrolyte additive strategy. With the rise of artificial intelligence technology, machine learning (ML) provides an avenue to promote upgrading of energy storage devices.

Antimicrobial Activity of Nano-GeO/CTAB Complex Against Fungi and Bacteria Isolated from Paper.

Microbial attack, particularly fungal degradation of cellulose, is a leading cause of paper damage. To address fungal spores and the rising concern of microbial drug resistance, a nano-Germanium dioxide (GeO)/cetyltrimethylammonium bromide (CTAB) complex (nano-GeO/CTAB complex) with potent antibacterial properties was synthesized. Its inhibitory effects were evaluated against bacteria, including Gram-positive and Gram-negative , as well as fungi isolated from paper ( spp.