1 results match your criteria: "Center for Kidney Diseases Translational Medicine of Liaoning ProvinceDalian[Affiliation]"
Inhibiting post-translational core fucosylation protects against albumin-induced proximal tubular epithelial cell injury.
Am J Transl Res
October 2017
Department of Nephrology, The First Affiliated Hospital, Institute for Nephrology Research of Dalian Medical University, Center for Kidney Diseases Translational Medicine of Liaoning ProvinceDalian, China.
Article Synopsis
- * The research involved creating a cell model to test how inhibiting the core fucosylation-related gene Fut8 affects albumin-induced damage to PTECs, using techniques like RNA interference and various protein assays.
- * Results showed that inhibiting core fucosylation was more effective than targeting megalin or TGFβRII alone and could reduce inflammation, oxidative stress, and fibrosis in PTECs, suggesting a new potential therapy for kidney injury