2 results match your criteria: "Center for Intestinal Neuroimmune Interactions[Affiliation]"
Characterisation of MRGPRX2 mast cells in irritable bowel syndrome.
Gut
February 2025
Center for Intestinal Neuroimmune Interactions, Translational Research in GastroIntestinal Disorders (TARGID), Chronic Diseases, Metabolism, and Ageing (CHROMETA), KU Leuven Biomedical Sciences Group, Leuven, Flanders, Belgium
Background: Mast cell activation is an important driver of abdominal pain in irritable bowel syndrome (IBS). While evidence supports the role of IgE-mediated mast cell activation in visceral pain development in IBS, the role of pseudoallergic MRGPRX2-mediated mast cell activation in this process remains unknown.
Objective: We investigated whether MRGPRX2-mediated mast cell activation plays a role in abdominal pain development in patients with IBS.
Fecal Proteolytic Bacteria and Staphylococcal Superantigens Are Associated With Abdominal Pain Severity in Irritable Bowel Syndrome.
Am J Gastroenterol
March 2025
Center for Intestinal Neuroimmune Interactions, Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, Leuven, Belgium.
Introduction: Changes in the composition of the gut microbiota have been associated with the development of irritable bowel syndrome (IBS). However, to what extent specific bacterial species relate to clinical symptoms remains poorly characterized. We investigated the clinical relevance of bacterial species linked with increased proteolytic activity, histamine production, and superantigen (SAg) production in patients with IBS.
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