A new single-well potential stochastic resonance algorithm to detect the weak signal.

Based on the stochastic resonance theory, a new single-well potential stochastic resonance algorithm (SSR) to improve the signal-to-noise ratio (SNR) is presented. In the new algorithm, stochastic resonance takes place in a single-well potential driven only by the noise. The effect on the proposed algorithm is discussed.

A Duffing oscillator algorithm to detect the weak chromatographic signal.

Based on the Duffing equation, a Duffing oscillator algorithm (DOA) to improve the signal-to-noise ratio (SNR) was presented. By simulated and experimental data sets, it was proven that the signal-to-noise ratio (SNR) of the weak signal could be greatly enhanced by this method. Using signal enhancement by DOA, this method extends the SNR of low concentrations of methylbenzene from 2.

[Rapid analysis of antiepileptic drugs in human plasma by micellar electrokinetic capillary chromatography].

Aim: To develop a rapid and feasible method based on micellar electrokinetic capillary chromatography (MECC) for the simultaneous determination of antiepileptic drugs (AEDs)--phenytoin (PHT), phenobarbital (PB), carbamazepine (CBZ), primidone (PRM) and clonazepam (CZP) in human plasma.

Methods: Several factors that impact the separation of AEDs with MECC were investigated, such as concentration of sodium dodecyl sulfate (SDS), buffer compositions, pH, organic modifier, internal diameter and temperature, and an optimized MECC running condition was obtained the running buffer consisted of 8 mmol x L(-1) phosphate, 3 mmol x L(-1) sodium tetraborate, and 50 mmol x L(-1) sodium dodecylsulfate (SDS) (pH 8.0), containing acetonitrile (ACN) (18%) as organic modifier.

Stochastic resonance is applied to quantitative analysis for weak chromatographic signal of roxithromycin in beagle dog plasma.

Based on the theory of stochastic resonance, the signal to noise ratio (SNR) of HPLC/UV chromatographic signal of roxithromycin is enhanced by cooperation of signal, noise and nonlinear system. A simple new method for the determination of low concentration of roxithromycin in beagle dog plasma is presented. Using signal enhancement by stochastic resonance, this method extends the limit of quantitation from the reported 0.

Application of stochastic resonance to quantitative analysis of weak chromatographic signal of phenazopyridine in human plasma.

Aim: To apply stochastic resonance algorithm (SRA) to quantitative analysis of weak chromatographic signal, which was embedded in the noise.

Methods: Based on the theory of stochastic resonance (SR), a simple and effective SRA has been established to improve analytical detection limits of chromatographic analysis, which apply to enhance the signal to noise ratio by the optimization of the parameters and Runge-Kutta method, was established. The method was used to quantitative analysis of phenazopyridine in human plasma by HPLC/UV.

Determination of loratadine in human plasma by HPLC with fluorescence detector and study on its bioavailability.

Aim: To establish an HPLC-fluorescence method for determination of loratadine in human plasma and evaluate its relative bioavailability.

Methods: An Alltech-C18 column and a mobile phase of acetonitrile-water-glacial acetic acid-triethylamine (90:100:6:0.15) were used.