5,658 results match your criteria: "Center for Food Safety[Affiliation]"
Allergenic risk assessment of porcine myoglobin expressed by engineered .
Fundam Res
September 2024
School of Food Science and Technology, International Joint Laboratory on Food Safety, Synergetic Innovation Center of Food Safety and Quality Control, Jiangnan University, Wuxi 214122, China.
Article Synopsis
- Myoglobin from engineered fermentation is used as a color additive in meat alternatives, but its allergy potential is not well understood.
- A study found no allergy-related proteins in porcine myoglobin, and simulated digestion indicated it was not very resilient to digestive processes.
- Sensitization was observed in mice with specific antibodies showing allergic reactions, suggesting that the non-myoglobin protein part may cause these allergies, emphasizing the need for better purification methods.
Assessment of the effects of cannabidiol and a CBD-rich hemp extract in .
Front Toxicol
October 2024
Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, United States Food and Drug Administration, Laurel, MD, United States.
Consumer use of cannabidiol (CBD) is growing, but there are still data gaps regarding its possible adverse effects on reproduction and development. Multiple pathways and signaling cascades involved in organismal development and neuronal function, including endocannabinoid synthesis and signaling systems, are well conserved across phyla, suggesting that can model the effects of exogenous cannabinoids. The effects in on oxidative stress response (OxStrR), developmental timing, juvenile and adult spontaneous locomotor activity, reproductive output, and organismal CBD concentrations were assessed after exposure to purified CBD or a hemp extract suspended in 0.
View Article and Find Full Text PDFCo-occurrence and correlation of arsenic, cadmium, and lead in processed foods intended for infants and young children: evaluation of two statistical approaches adapted to censored data and their implications for risk management.
Food Addit Contam Part A Chem Anal Control Expo Risk Assess
January 2025
Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, College Park, MD, USA.
Article Synopsis
- The study investigated the presence of arsenic, cadmium, and lead in processed foods meant for infants and young children, focusing on how these toxic elements co-occur in different food categories.
- It used statistical methods to evaluate correlations between the elements, finding that most food categories showed positive correlations, meaning if one element is high, others tend to be too.
- The research suggests that understanding these correlations is important for regulating food safety, as it can affect how supply levels are assessed against maximum allowable limits.
Neonicotinoid pesticides: evidence of developmental neurotoxicity from regulatory rodent studies.
Front Toxicol
October 2024
Center for Food Safety, Washington, DC, United States.
Article Synopsis
- * A comprehensive study assessed unpublished rodent developmental neurotoxicity data on five neonicotinoids administered to pregnant rats, revealing nicotine-like effects such as reduced brain size in offspring, suggesting possible links to ADHD.
- * Significant brain region shrinkage was observed in high-dose offspring of multiple neonicotinoids, with specific auditory reflex impairments noted for acetamiprid and clothianidin, while some data submissions to the EPA were incomplete.
The role of ferroptosis in environmental pollution-induced male reproductive system toxicity.
Environ Pollut
December 2024
Technology Innovation Center for Food Safety Surveillance and Detection (Hainan), Sanya Institute of China Agricultural University, Sanya, 572025, China; Key Biology Laboratory of Chinese Veterinary Medicine, Ministry of Agriculture and Rural Affairs, Beijing, 100193, China; National Center of Technology Innovation for Medicinal Function of Food, National Food and Strategic Reserves Administration, Beijing, 100193, China. Electronic address:
This article provides a comprehensive review of the toxic effects of environmental pollution on the male reproductive system, with a particular emphasis on ferroptosis, a form of programmed cell death. Research has shown that environmental pollutants, such as heavy metals, pesticide residues, and plastic additives, can disrupt oxidative stress, increasing the production of reactive oxygen species (ROS) in germ cells. This disruption damages cellular lipids, proteins, and DNA, culminating in cell dysfunction or death.
View Article and Find Full Text PDFBeneficial Role of Heat-Treated Lactobacillus sakei HS-1 on Growth Performance, Nutritional Status and Gut Microbiota in Weaned Piglets.
J Anim Physiol Anim Nutr (Berl)
October 2024
Laboratory of Veterinary Public Health, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
In the swine industry, there is a strong need to replace an antibiotic growth promoter (AGP) used as feed additives in weaned piglets to enhance nutrient utilization in their diets and improve growth performance. Lactobacillus sakei HS-1 strain is a microbial preparation isolated from pickles. The study aim is to investigate the effectiveness of heat-treated L.
View Article and Find Full Text PDFProteo-genomic analyses in relatively lean Chinese adults identify proteins and pathways that affect general and central adiposity levels.
Commun Biol
October 2024
Clinical Trial Service Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Adiposity is an established risk factor for multiple diseases, but the causal relationships of different adiposity types with circulating protein biomarkers have not been systematically investigated. We examine the causal associations of general and central adiposity with 2923 plasma proteins among 3977 Chinese adults (mean BMI = 23.9 kg/m²).
View Article and Find Full Text PDFMosaic loss of chromosome Y, tobacco smoking and risk of age-related lung diseases: insights from two prospective cohorts.
Eur Respir J
December 2024
Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China
Article Synopsis
- The study investigates the link between mosaic loss of chromosome Y (mLOY) and the risk of lung diseases in older men, using data from over 260,000 participants in two major biobanks.
- Findings indicate that individuals with mLOY have a higher risk of developing various lung diseases, including chronic obstructive pulmonary disease (COPD), lung cancer, and idiopathic pulmonary fibrosis (IPF).
- The research suggests that mLOY may serve as a significant predictor for age-related lung diseases, particularly for current smokers, highlighting the importance of smoking cessation to reduce associated health risks.
Modelling personal temperature exposure using household and outdoor temperature and questionnaire data: Implications for epidemiological studies.
Environ Int
October 2024
Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Article Synopsis
- Non-optimal temperature significantly contributes to global disease burden, but most studies have focused on outdoor temperatures, potentially leading to misclassification of personal temperature exposure.
- The CKB-Air study analyzed temperature data from 477 participants across personal, household, and outdoor settings during summer and winter in China, recording around 88,000 person-hours of data.
- The study found strong correlations between personal and household temperatures in winter and significant predictors for personal temperature exposure, achieving good prediction accuracy, while identifying a U-shaped relationship between personal temperature exposure and heart rate.
Amino acid metabolites profiling in unpredictable chronic mild stress-induced depressive rats and the protective effects of Gastrodia elata Blume and gastrodin.
J Ethnopharmacol
January 2025
Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan; Center for Food and Biomolecules, National Taiwan University, Taipei, Taiwan; National Center for Food Safety Education and Research, National Taiwan University, Taipei, Taiwan. Electronic address:
Article Synopsis
- - Major depressive disorder (MDD) affects around 350 million people globally, with studies indicating altered amino acids in blood as potential biomarkers for understanding depression.
- - The study aimed to explore how supplementing Gastrodia elata Blume (GEB) and its active compound gastrodin (GAS) might reverse these altered amino acid profiles in a model of depression using rats.
- - Findings revealed that GEB and GAS supplementation successfully reversed changes in key amino acids related to depressive-like behaviors in rats, suggesting their potential for alleviating depression and providing insights for future treatments.
Novel mobile colistin resistance gene mcr-4.9 in Vibrio cholerae from migratory birds.
Drug Resist Updat
November 2024
Technology Innovation Center for Food Safety Surveillance and Detection (Hainan), Sanya Institute of China Agricultural University, Sanya 572025, China; National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing 100193, China. Electronic address:
Effect of pilot-scale high-temperature short-time processing on the retention of key micronutrients in a fortified almond-based beverage: implications for fortification of plant-based milk alternatives.
Front Nutr
September 2024
Division of Food Processing Science and Technology, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Office of Food Safety, Bedford Park, IL, United States.
Article Synopsis
- * Results show that key vitamins like A, D2, riboflavin, and total vitamin B6 remained stable, while thiamin decreased by 17.9% and total vitamin B3 increased by 35.2% after processing at 116°C.
- * Overall, the findings suggest that HTST processing generally preserves micronutrient levels in almond-based beverages, making fortification a beneficial method for enhancing their nutritional value.
An investigation of an outbreak of Typhimurium infections linked to cantaloupe - United States, 2022.
Food Control
December 2024
Center for Food Safety and Applied Nutrition, Food and Drug Administration, College Park, MD, USA.
Article Synopsis
- * The FDA traced the outbreak to 14 individuals who had purchased cantaloupes from a packing house that also supplied several points of sale, while environmental samples from the affected growers showed contamination.
- * This outbreak marks the third instance in the past decade of salmonellosis tied to melons from this region, highlighting the ongoing need for improved practices to prevent contamination in melon farming and better public education on food safety.
Uptake of Per- and Polyfluoroalkyl Substances in Mixed Forages on Biosolid-Amended Farm Fields.
J Agric Food Chem
October 2024
Maine Center for Disease Control and Prevention, 286 Water Street, 11 State House Station, Augusta, Maine 04333, United States.
Models to predict perfluorooctanesulfonic acid (PFOS) concentrations in livestock based on soil concentrations are essential to guide decisions surrounding food testing and farm management. A key parameter in modeling soil-to-livestock exposure pathways is the plant transfer factor (TF) from soil into forages. Uptake of PFOS and other individual per- and polyfluoroalkyl substances (PFASs) were examined in perennial mixed grasses and legumes on PFAS-contaminated farm fields.
View Article and Find Full Text PDFSerine affects engulfment during the sporulation process in Clostridium perfringens strain SM101.
Anaerobe
December 2024
Graduate School of Veterinary Science, Osaka Metropolitan University, 1-58 Rinku Ourai Kita, Izumisano, Osaka, 598-8531, Japan; Osaka International Research Center for Infectious Diseases, Osaka Metropolitan University, 1-58 Rinku Ourai Kita, Izumisano, Osaka, 598-8531, Japan; Research Center for Food Safety, Osaka Metropolitan University, 1-58 Rinku Ourai Kita, Izumisano, Osaka, 598-8531, Japan.
Objectives: Although Clostridium perfringens sporulation is a key event in the pathogenesis of food-borne illness, the molecules and underlying mechanisms responsible for regulating sporulation are incompletely understood. The present study sought to identify amino acids that affect sporulation in C. perfringens strain SM101.
View Article and Find Full Text PDFEnhanced emulsification properties of microalgae protein through gellan gum conjugation: Mechanistic insights and applications in curcumin encapsulation and delivery.
Int J Biol Macromol
November 2024
Systems Engineering Institute, AMS, PLA, Bejing 100010, China. Electronic address:
Article Synopsis
- The study investigates how gellan gum (GG) affects the emulsification properties of microalgae protein (MP), which are generally poor, particularly under acidic and neutral conditions.
- Researchers created MP-GG complexes, optimizing pH levels for stability, and found that the addition of GG improved the stability and droplet size of emulsions compared to MP alone.
- The results suggest that emulsions with a higher oil phase (70%) retain curcumin more effectively but have lower bioaccessibility, indicating potential for better nutrient delivery applications.
Caffeine intake from foods and beverages and trends among Chinese children and adolescents: 2004-2018.
Food Chem Toxicol
November 2024
School of Public Health and Emergency Management, Southern University of Science and Technology, 1088 Academy Avenue, Nanshan District, Shenzhen, 518055, Guangdong, China. Electronic address:
Background: The popularity of caffeinated foods and beverages poses risks of high caffeine exposure among Chinese children and adolescents. Nevertheless, there is a lack of national assessments on their caffeine consumption.
Objective: To estimate daily caffeine intake and analyze time trends among Chinese children and adolescents.
Fast determination of organophosphate esters and their metabolites in human matrices by a straightforward cold-induced strategy coupled with HPLC-MS/MS.
Anal Bioanal Chem
November 2024
School of Public Health and Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing, 100069, China.
Article Synopsis
- Organophosphate esters (OPEs) and their metabolites (mOPEs) are increasingly recognized as harmful environmental pollutants, prompting the need for better analytical methods to measure them in human samples.
- This study developed a streamlined analytical technique using cold-induced liquid-liquid extraction (CI-LLE) and HPLC-MS/MS to simultaneously detect 18 OPEs and 10 mOPEs in human serum, urine, and milk.
- Results confirmed that the method had high sensitivity (with detection limits as low as 0.1 pg/mL), good recovery rates (80-123%), and minimal interference from the sample matrix, highlighting the widespread presence of OPEs and mOPEs in humans.
Two novel plasmids harbouring the multiresistance gene cfr in porcine Staphylococcus equorum.
J Glob Antimicrob Resist
December 2024
Technology Innovation Center for Food Safety Surveillance and Detection (Hainan), Sanya Institute of China Agricultural University, Sanya, Hainan, China; National Key Laboratory of Veterinary Public Health and Safety, College of Veterinary Medicine, China Agricultural University, Beijing, China. Electronic address:
Article Synopsis
- Scientists are worried about a bacteria called Staphylococcus equorum that can resist many medicines because it has special genes.
- They studied one specific sample of this bacteria that has two unique pieces of DNA called plasmids that help it resist medicine.
- The findings show that these plasmids also have genes that help the bacteria survive against heavy metals, making it a bigger threat to health that needs to be monitored closely.
Campylobacter Diversity Along the Farm-to-Fork Continuum of Pastured Poultry Flocks in the Southeastern United States.
Zoonoses Public Health
February 2025
Egg & Poultry Production Safety Research Unit, USDA-ARS, US National Poultry Research Center, Athens, Georgia, USA.
Article Synopsis
- Increased consumer interest in pasture-raised, antibiotic-free poultry has led to more pastured poultry operations in the U.S., raising concerns about Campylobacter exposure.
- A study sampled 40 pastured poultry flocks across nine farms, revealing a Campylobacter prevalence of 47.91%, with the highest load in the caeca and the lowest in whole carcass rinses.
- Campylobacter jejuni and Campylobacter coli were the most common isolates found, with significant antibiotic resistance, particularly to tetracycline, but low rates of multidrug resistance were observed.
Association of autosomal mosaic chromosomal alterations with risk of bladder cancer in Chinese adults: a prospective cohort study.
Cell Death Dis
September 2024
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, 100191, China.
Article Synopsis
- The study explores the link between autosomal mosaic chromosomal alterations (mCAs) and bladder cancer using data from nearly 100,000 participants in the China Kadoorie Biobank who were cancer-free at the start.
- Researchers found that individuals with autosomal mCAs had a significantly higher risk of developing bladder cancer, with the highest risk associated with mosaic loss events.
- The results also indicated that lower levels of physical activity increased the cancer risk for those with mCAs, suggesting that physical activity might be a beneficial factor for mCAs carriers to reduce their risk.
Microbial interactions shaping host attractiveness: insights into dynamic behavioral relationships.
Curr Opin Insect Sci
December 2024
New Cornerstone Science Laboratory, Tsinghua-Peking Joint Center for Life Sciences, School of Basic Medical Sciences, Tsinghua University, Beijing 100084, China; Institute of Infectious Diseases, Shenzhen Bay Laboratory, Shenzhen, Guangdong 518000, China; Institute of Pathogenic Organisms, Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, China; Southwest United Graduate School, Kunming 650092, China. Electronic address:
Insects discern the presence of hosts (host plants) by integrating chemosensory, gustatory, and visual cues, with olfaction playing a pivotal role in this process. Among these factors, volatile signals produced by host-associated microbial communities significantly affect insect attraction. Microorganisms are widely and abundantly found on the surfaces of humans, plants, and insects.
View Article and Find Full Text PDFEffect of different initiators on the properties of diacetone acrylamide grafted starch-based adhesive.
Int J Biol Macromol
September 2024
State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, China; Collaborative Innovation Center for Food Safety and Quality Control, Jiangnan University, Wuxi 214122, China.
Environmentally friendly and non-toxic bio-based adhesives are emerging as the most promising substitutes for petroleum-based adhesives, attracting increasing attention. This work involved the synthesis of a starch-based adhesive for particleboards by grafting diacetone acrylamide (DAAM) onto starch. The graft polymerization was initiated using three different initiators: ammonium persulfate (APS), hydrogen peroxide (HO)/ammonium ferrous sulfate system, and ceric ammonium nitrate (CAN).
View Article and Find Full Text PDFStrengths and limitations of the worm development and activity test (wDAT) as a chemical screening tool for developmental hazards.
Toxicol Appl Pharmacol
November 2024
Division of Toxicology, Office of Applied Research and Safety Assessment, Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Laurel, MD, USA.
Article Synopsis
- The worm Development and Activity Test (wDAT) uses the model organism C. elegans to assess developmental milestones and spontaneous locomotor activity, identifying impacts of various toxicants like arsenic and lead.
- The wDAT found that certain teratogenic chemicals (5-fluorouracil, hydroxyurea, and ribavirin) caused developmental delays and altered activity levels in C. elegans, paralleling mammalian development impacts.
- While the wDAT shows promise for recognizing developmental toxicants, further studies with more controls are needed to enhance its reliability and effectiveness for broader toxicity assessments.
Efficient Solid-Phase Extraction of Neonicotinoid Insecticides from Environmental Water and Drink Samples Using a Postmodified Metal-Organic Framework.
J Agric Food Chem
October 2024
College of Environmental Science and Engineering, Shandong Analysis and Test Center, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China.
Article Synopsis
- * A new material, MIL-101-SONa, was developed to effectively extract NNIs from environmental samples, utilizing modifications to improve interaction and electrostatic attraction.
- * The method using MIL-101-SONa demonstrated impressive detection capabilities with low thresholds and high accuracy, successfully identifying NNI levels in various beverages, indicating its potential for practical use in monitoring NNI contamination.