5,661 results match your criteria: "Center for Food Safety[Affiliation]"

Polycyclic aromatic hydrocarbons (PAHs) represent a category of persistent organic pollutants that pose a global concern in the realm of food safety due to their recognized carcinogenic properties in humans. Food can be contaminated with PAHs that are present in water, air, or soil, or during food processing and cooking. The wide and varied sources of PAHs contribute to their persistent contamination of food, leading to their accumulation within these products.

View Article and Find Full Text PDF

Prospective modeling and estimating the epidemiologically informative match rate within large foodborne pathogen genomic databases.

BMC Res Notes

July 2024

Biostatistics and Bioinformatics Staff, Office of Analytics and Outreach, Center for Food Safety and Applied Nutrition, U. S. Food and Drug Administration, College Park, MA, USA.

Objectives: Much has been written about the utility of genomic databases to public health. Within food safety these databases contain data from two types of isolates-those from patients (i.e.

View Article and Find Full Text PDF

Background: Oxford Nanopore provides high throughput sequencing platforms able to reconstruct complete bacterial genomes with 99.95% accuracy. However, even small levels of error can obscure the phylogenetic relationships between closely related isolates.

View Article and Find Full Text PDF

Irinotecan-loaded magnetite-silica core-shell systems for colorectal cancer treatment.

Int J Pharm

August 2024

Faculty of Medical Engineering, National University of Science and Technology Politehnica Bucharest, 060042 Bucharest, Romania; Department of Life and Environmental Science, National Institute for R&D in Physics and Nuclear Engineering Horia Hulubei, 30 Reactorului, 077125 Magurele, Romania. Electronic address:

Colorectal cancer represents a worldwide spread type of cancer and it is regarded as one of the leading death causes, along with lung, breast, and prostate cancers. Since conventional surgical resection and chemotherapy proved limited efficiency, the use of alternative drug delivery systems that ensure the controlled release of cytostatic agents possess immense potential for treatment. In this regard, the present study aimed to develop and evaluate the efficiency of a series of irinotecan-loaded magnetite-silica core-shell systems.

View Article and Find Full Text PDF

Public health campaigns addressing COVID-19 vaccination beliefs may be effective in changing COVID-19 vaccination behaviors, particularly among people who remain vaccine hesitant. The "" COVID-19 public education campaign (the Campaign) was designed to increase COVID-19 vaccine confidence and uptake. This study aims to evaluate whether Campaign dose was associated with changes in vaccination beliefs related to COVID-19 vaccine concerns and perceived risks, the importance of COVID-19 vaccines, the perceived benefits of COVID-19 vaccination, normative beliefs about COVID-19 vaccination, and perceptions about general vaccine safety and effectiveness.

View Article and Find Full Text PDF

[Research progress on the driving factors and mechanisms of antimicrobial resistance production and spread from the perspective of One Health].

Zhonghua Yu Fang Yi Xue Za Zhi

June 2024

NHC Key Laboratory of Food Safety Risk Assessment/Chinese Academy of Medical Science Research Unit (2019RU014), China National Center for Food Safety Risk Assessment, Beijing 100021, China.

Antimicrobial resistance poses a serious threat to public health and is one of the major challenges worldwide. As global social, economic, and environmental changes lead to increased exposure of populations to antimicrobials, the antimicrobial resistance of pathogens has accelerated and resulted in weakened clinical infection treatment effects. This article reviews the main mechanisms and driving factors of the production and spread of antimicrobial resistance from the perspective of "One Health"and discusses methods and strategies for controlling antimicrobial resistance from multiple dimensions.

View Article and Find Full Text PDF

Relevance of genetic causes and environmental adaptation of Cronobacter spp. isolated from infant and follow-up formula production factories and retailed products in China: A 7-year period of continuous surveillance based on genome-wide analysis.

Sci Total Environ

October 2024

NHC Key Laboratory of Food Safety Risk Assessment, Chinese Academy of Medical Science Research Unit (2019RU014), China National Center for Food Safety Risk Assessment, Beijing City, PR China; Department of Nutrition and Food Safety, Peking Union Medical College; Research Unit of Food Safety, Chinese Academy of Medical Sciences, PR China. Electronic address:

The possible contamination routes, environmental adaptation, and genetic basis of Cronobacter spp. in infant and follow-up formula production factories and retailed products in mainland China have been determined by laboratory studies and whole-genome comparative analysis in a 7-year nationwide continuous surveillance spanning from 2012 to 2018. The 2-year continuous multicenter surveillance of the production process (conducted in 2013 and 2014) revealed that the source of Cronobacter spp.

View Article and Find Full Text PDF

Unlabelled: Tattooing and use of permanent makeup (PMU) have dramatically increased over the last decade, with a concomitant increase in ink-related infections. Studies have shown evidence that commercial tattoo and PMU inks are frequently contaminated with pathogenic microorganisms. Considering that tattoo inks are placed into the dermal layer of the skin where anaerobic bacteria can thrive and cause infections in low-oxygen environments, the prevalence of anaerobic and aerobic bacteria should be assessed in tattoo and PMU inks.

View Article and Find Full Text PDF

Characterization of two virulent Salmonella phages and transient application in egg, meat and lettuce safety.

Food Res Int

August 2024

MOE Key Laboratory of Bio-Intelligent Manufacturing, School of Bioengineering, Dalian University of Technology, Dalian 116024, China; Dalian SEM Bio-Engineering Technology Co. Ltd., Dalian 116620, China; Center for Food Safety of Animal Origin, Ministry of Education, Dalian University of Technology, Dalian 116600, China. Electronic address:

Article Synopsis
  • Salmonella is a major foodborne pathogen that threatens food safety and public health, with growing concerns over antibiotic misuse leading to drug residues in food products.
  • * The study identifies two new virulent bacteriophages, sp11241 and 8-19, that effectively target Salmonella enterica serotype Enteritidis, showing potential as eco-friendly solutions to control this pathogen in food.
  • * When tested on whole chicken eggs, raw chicken meat, and lettuce at various concentrations, the phages significantly reduced Salmonella levels, demonstrating their effectiveness at low temperatures and highlighting their potential for food safety applications.
View Article and Find Full Text PDF

Campylobacter jejuni is one of the major causes of bacterial gastrointestinal disease in humans worldwide. This foodborne pathogen colonizes the intestinal tracts of chickens, and consumption of chicken and poultry products is identified as a common route of transmission. We analyzed two C.

View Article and Find Full Text PDF

Copper II oxide nanoparticles (CuO NPs), a kind of widely used nanomaterial, have been detected in food and the environment, which has aroused widespread public concern. Recently, increasing data have suggested that intestinal microecology is closely related to immune homeostasis. However, the intestinal immunotoxicity induced by CuO NPs through intestinal microbiota is still unknown.

View Article and Find Full Text PDF

What Is Already Known About This Topic?: Chloropropanols, along with their fatty acid esters and glycidyl fatty acid esters (GEs), are prevalent contaminants in a variety of processed foods, posing potential health risks to humans.

What Is Added By This Report?: In the Sixth China Total Diet Study (TDS), 3-monochloropropane-1,2-diol esters (3-MCPD esters) and GEs were identified as the predominant chloropropanols and their esters in composite food samples. Vegetables (47.

View Article and Find Full Text PDF

What Is Already Known About This Topic?: Foodborne diseases, representing significant food safety and public health challenges globally, are not well-documented in terms of incidence, particularly for cases characterized by acute gastroenteritis (AGI) in China.

What Is Added By This Report?: This study developed a pyramid model to estimate the incidence of five pathogens, stratified by gender and age. The estimated incidences per 100,000 people with 95% uncertainty intervals () are as follows: Norovirus, 3,188.

View Article and Find Full Text PDF

Enhancement of Calcium Chelating Activity in Peptides from Sea Cucumber Ovum through Phosphorylation Modification.

Foods

June 2024

Key Lab of Biotechnology and Bioresources Utilization of Ministry of Education, College of Life Science, Dalian Minzu University, Dalian 116600, China.

Recently, phosphorylation has been applied to peptides to enhance their physiological activity, taking advantage of its modification benefits and the extensive study of functional peptides. In this study, water-soluble peptides (WSPs) of sea cucumber ovum were phosphorylated in order to improve the latter's calcium binding capacity and calcium absorption. Enzymatic hydrolysis methods were screened via ultraviolet-visible absorption spectroscopy (UV-Vis), the fluorescence spectrum, and calcium chelating ability.

View Article and Find Full Text PDF

A Straightforward, Sensitive, and Reliable Strategy for Ethyl Carbamate Detection in By-Products from Baijiu Production by Enzyme-Linked Immunosorbent Assay.

Foods

June 2024

Research Unit of Food Safety, NHC Key Laboratory of Food Safety Risk Assessment, Ministry of Health, China National Center for Food Safety Risk Assessment, Chinese Academy of Medical Sciences (2019RU014), Beijing 100021, China.

Baijiu is a renowned Chinese distilled liquor, notable for its distinctive flavor profile and intricate production process, which prominently involves fermentation and distillation. Ethyl carbamate (EC), a probable human carcinogen, can be potentially formed during these procedures, thus prompting significant health concerns. Consequently, the contamination of EC during Baijiu production has become an increasingly pressing issue.

View Article and Find Full Text PDF

Hemp extracts and consumer products containing cannabidiol (CBD) and/or other phytocannabinoids derived from hemp have entered the marketplace in recent years. CBD is an approved drug in the United States for the treatment of certain seizure disorders. While effects of CBD in the liver have been well characterized, data on the effects of other cannabinoids and hemp extracts in the liver and methods for studying these effects in vitro are limited.

View Article and Find Full Text PDF

Determination of Patulin in Apple Juice and Apple-Derived Products Using a Robotic Sample Preparation System and LC-APCI-MS/MS.

Toxins (Basel)

May 2024

U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition, Office of Regulatory Science, 5001 Campus Drive, College Park, MD 20740, USA.

Patulin, a toxic mycotoxin, can contaminate apple-derived products. The FDA has established an action level of 50 ppb (ng/g) for patulin in apple juice and apple juice products. To effectively monitor this mycotoxin, there is a need for adequate analytical methods that can reliably and efficiently determine patulin levels.

View Article and Find Full Text PDF

This study examined the diversity and persistence of in the surface waters of agricultural regions of Brazil, Chile, and Mexico. Research groups (three in 2019-2020 and five in 2021-2022) conducted a long-term survey of surface water across 5-8 months annually ( = 30 monthly). On-site, each team filtered 10-L water samples with modified Moore Swabs to capture which were then isolated and identified using conventional microbiological techniques.

View Article and Find Full Text PDF

Identification and Prioritization of Organic Pollutants in Human Milk from the Yangtze River Delta, China.

Environ Sci Technol

July 2024

State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.

Article Synopsis
  • The study emphasizes the importance of analyzing pollutants in human milk to understand both maternal and infant exposure, noting that previous research often overlooked many substances.
  • A comprehensive analysis of 15 pooled human milk samples from the Yangtze River Delta revealed a total of 171 compounds, with 16 detected for the first time in human milk.
  • The research identified area-specific pollutants and established that polycyclic aromatic hydrocarbons (PAHs) only made up a small portion of the risk index, highlighting the need for increased focus on pollutants with various functional groups that have potential health risks.
View Article and Find Full Text PDF

Rare Earth Elements (REEs) have been implicated in potential health effects. However, the health risk of REE exposure among tea drinkers in China remains poorly understood. This study aimed to characterize the concentration of REEs in different tea categories and evaluate the associated health risks for tea consumers in China.

View Article and Find Full Text PDF

Visualized analysis of microplastics in residents' diets and regional investigation of China.

Sci Total Environ

October 2024

College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China; Sanya Institute of China Agricultural University, Hainan 572025, China; China National Center for Food Safety Risk Assessment, Beijing 100021, China. Electronic address:

Microplastics are widely distributed in ecosystems and are increasingly found in food. This poses a potential threat to human health. However, current detections of microplastic in food primarily focused on the simple matrices, such as water, milk, and beverages, with relatively few methods available for complex matrices.

View Article and Find Full Text PDF

Macrophage polarization as a novel endpoint for assessing combined risk of phthalate esters.

Environ Int

August 2024

NHC Key Lab of Food Safety Risk Assessment, China National Center for Food Safety Risk Assessment, Beijing, China; Department of Nutrition and Food Safety, Peking Union Medical College, Research Unit of Food Safety, Chinese Academy of Medical Sciences, Beijing, China; School of Public Health, Southern Medical University, Food Safety and Health Research Center, Guangdong Key Laboratory of Tropical Disease Research, Guangzhou, China. Electronic address:

Article Synopsis
  • The study investigates the combined effects of phthalate esters (PAEs) on human health, using an in vitro model with human macrophages to assess toxicity and mechanisms.
  • Findings indicate that different PAEs have varying impacts on M2 macrophage polarization, with mono(2-ethylhexyl) phthalate (MEHP) being the most effective at suppressing this polarization.
  • In vivo results showed that a mixture of PAEs led to significant liver health issues, supporting the need for further analysis of the health risks associated with combined exposure to these compounds.
View Article and Find Full Text PDF