and formula alleviates depressive behaviors microglia regulation in an unpredictable chronic mild stress animal model.

Background And Aim: (CM) and (AM) are medicinal mushrooms with potential applications in the treatment of mood disorders, including depression and anxiety. While research suggests that both CM and AM possess anti-inflammatory properties and hold potential for treating depression when administered separately, there is limited knowledge about their efficacy when combined in a formula, as well as the underlying mechanism involving the modulation of microglia.

Experimental Procedure: Rats received oral administrations of the low-dose formulation, medium-dose formulation, and high-dose formulation over 28 consecutive days as part of the UCMS protocols.

Diarrheagenic Outbreak Reporting to Foodborne Disease Outbreaks Surveillance System - China, 2011-2022.

What Is Already Known About This Topic?: Foodborne diarrheagenic (DEC) outbreaks constitute a significant global public health concern, yet comprehensive data on outbreak incidence and epidemiological characteristics in China remain limited.

What Is Added By This Report?: Between 2011 and 2022, there were 413 foodborne DEC outbreaks reported to foodborne disease outbreak surveillance system, resulting in 8,127 illnesses, 2,565 hospitalizations, and one fatality. Enteroaggregative (EAEC) emerged as the predominant causative pathogen (48.

Epidemiological Characteristics of Sporadic Foodborne Diseases Caused by - China, 2013-2022.

Introduction: () is a common foodborne pathogen in coastal areas of China. Most epidemiological studies on have focused on foodborne disease outbreaks, with fewer studies based on long-term, continuous, and systematic sentinel surveillance.

Methods: Data were collected from the national foodborne disease active surveillance program in 31 provincial-level administrative divisions (PLADs) in China from 2013 to 2022.

Residue Analysis and Dietary Risk Assessment of 10 Neonicotinoid Insecticides in from Hainan Province of China.

In this study, residues of 10 neonicotinoid insecticides were tested with 143 fresh samples of using the QuEChERS method combined with UPLC-MS/MS. Based on the residue results, the point estimation method was used to assess dietary risks for adults and children, and the cumulative risk was assessed according to the hazard index () and relative potency factor () methods. The results showed that 71 out of 143 samples of fresh sold in Hainan tested positive for neonicotinoid insecticides, with a detection rate of 49.

Template-assembly activation of primer exchange reaction for on-site and sensitive detection of copper ions in blood.

The sensitive and accurate detection of copper ions is crucial for public health, medical research, and environmental monitoring. In this study, we developed a sensor based on template-assembly activation of the primer exchange reaction (PER) for the on-site detection of copper ions in blood. Copper ions triggered the assembly of two template fragments into a hairpin structure via a click-chemistry reaction, activating the PER.

Intestinal Barrier Damage and Growth Retardation Caused by Exposure to Polystyrene Nanoplastics Through Lactation Milk in Developing Mice.

Microplastics, defined as plastic fragments smaller than 5 mm, degrade from larger pollutants, with nanoscale microplastic particles presenting significant biological interactions. This study investigates the toxic effects of polystyrene nanoplastics (PS-NPs) on juvenile mice, which were exposed through lactation milk and drinking water at concentrations of 0.01 mg/mL, 0.

Melatonin attenuates BDE-209-caused spatial memory deficits in juvenile rats through NMDAR-CaMKⅡγ-mediated synapse-to-nucleus signaling.

Flame retardant polybrominated diphenyl ethers (PBDEs) accumulate in human bodies through food and dust ingestion, and cause neurobehavioral deficits with obscure mechanism. We aimed to investigate NMDAR-CaMKⅡγ-mediated synapse-to-nuclear communication involved in BDE-209-induced cognitive impairment, and alleviation from exogenous melatonin. Decreased NMDAR subunits GluN2A and 2B, autophosphorylation of CaMKⅡα, and postsynaptic GluA1 trafficking were observed in the hippocampus of juvenile rats after maternal BDE-209 exposure.

Occurrences of heavy metal in breast milk in China: Results of the third national breast milk survey.

To investigate the exposure of infants to heavy metal during lactation, breast milk from 24 provinces in China were detected. Among As, Cd, Cr, Hg, and Pb, the detection frequencies of As (85 %, 0.50 μg/L) and Cd (91 %, 0.

The effect of carbohydrates with different levels of digestibility on energy metabolism in vivo under hypobaric hypoxic conditions.

Current strategies for improving energy supply in hypobaric hypoxic environments are limited. Therefore, this study investigates the effects of four carbohydrates with different levels of digestibility on energy metabolism in vivo in hypobaric hypoxic environments. First, we characterized the four types of carbohydrates.

Morbidity, Mortality, and Epidemiological Features of Clinical Invasive Listeriosis Isolates from Sentinel Surveillance in Beijing, China, 2013-2022.

Listeriosis is a relatively rare but severe foodborne disease, which has significant public health concern of persons with underlying conditions and pregnant women. This study aimed to estimate the morbidity, mortality, and fatality rates of listeriosis over a 10-year period and clarify the epidemiological features of the pathogen in Beijing, China, based on voluntary reporting of sentinel surveillance. A total of 228 listeriosis cases were reported with annual morbidity rate of 1.

Causal Mediation Analysis of Foodborne Outbreaks in the United States: Serotypes and Food Vehicles.

Various serotypes have caused numerous foodborne outbreaks associated with food vehicles in different categories. This study provides evidence on the occurrence and inter-relations between serotypes and the number of deaths mediated by the number of illnesses and hospitalizations. Confirmed foodborne outbreaks of serotypes (n = 2868) that occurred between 1998 and 2021 were obtained from the Centers for Disease Control and Prevention National Outbreak Reporting System.

Determination of Amino Acids of Novel Food in Food by HPLC Coupled with Pre-Column Derivatization.

A method for simultaneous determination of Theanine and γ-aminobutyric acid (GABA), as the novel food of amino acids, which was established using pre-column derivatization and high-performance liquid chromatography (HPLC). 4-Dimethylaminoazobe nzene-4'-sulfonyl chloride (DABS-Cl) is employed as the derivatization reagent with chromophore linked to Theanine and GABA, which lacks chromophore for DAD analysis in its pristine structure. After the detection wavelength was confirmed, the chromatographic and derivatization conditions were also optimized, including the chromatographic column, mobile phases and their gradient, derivatization temperature and time, the additive amount of buffer solution and derivatization reagent.

The Detoxification Effects of Melatonin on Aflatoxin-Caused Toxic Effects and Underlying Molecular Mechanisms.

Aflatoxins (AFTs) are a form of mycotoxins mainly produced by and , which are common contaminants in various agricultural sources such as feed, milk, food, and grain crops. Aflatoxin B1 (AFB1) is the most toxic one among all AFTs. AFB1 undergoes bioactivation into AFB1-8,9-epoxide, then leads to diverse harmful effects such as neurotoxicity, carcinogenicity, hepatotoxicity, reproductive toxicity, nephrotoxicity, and immunotoxicity, with specific molecular mechanisms varying in different pathologies.

Regional antimicrobial resistance gene flow among the One Health sectors in China.

Background: Antimicrobial resistance poses a significant threat to global health, with its spread intricately linked across human, animal, and environmental sectors. Revealing the antimicrobial resistance gene (ARG) flow among the One Health sectors is essential for better control of antimicrobial resistance.

Results: In this study, we investigated regional ARG transmission among humans, food, and the environment in Dengfeng, Henan Province, China by combining large-scale metagenomic sequencing with culturing of resistant bacterial isolates in 592 samples.

Preparation of sulfonic acid functionalized metal organic frameworks and their application in the online solid phase extraction of parabens and sulfonamides in pre-cooked foods.

Unlabelled: Mixed-mode sorbents exhibit two or more primary retention mechanisms, which can enhance the selectivity and capacity of the extraction process in a single step. In this study, a facile approach was proposed to prepare functionalized metal-organic frameworks (MOFs) by post-synthetic oxidation. The composites could be varied independently for each processing step, resulting in four frameworks to meet different sample pretreatment requirements.

Benzotrithiophene-based covalent organic frameworks for sensitive fluorescence detection and efficient removal of Ag from drinking water.

The simultaneous detection and removal of Ag from drinking water was crucial for preventing human health, while it was also extremely challenging due to bifunctional materials that combine both Ag adsorption and detection functions rarely being explored. In this study, a benzotrithiophene-based covalent organic framework (TAPA-BTT) was synthesized and applied to detect and remove Ag. TAPA-BTT exhibited high crystallinity, a large specific surface area, and good thermal stability.

Nano-sized polystyrene plastics toxicity: Necroptosis pathway caused by autophagy blockade and lysosomal dysfunction.

The persistent detection of nano-sized plastic particles in humans, animals, and animal-derived products underscores the potential impact of these particles on living organisms. Consequently, the toxicology of such particles has emerged as a pivotal research interests in recent years. In this study, NP was synthesized successfully with an average particle size of 100 nm using a emulsion polymerization method as model particles.

Adiposity and risks of gastrointestinal cancers: A 10-year prospective study of 0.5 million Chinese adults.

Associations of adiposity with risks of oesophageal squamous cell carcinoma (ESCC) and non-cardia stomach cancer, both prevalent in China, are still inconclusive. While adiposity is an established risk factor for colorectal cancer, the relevance of fat-free mass and early-adulthood adiposity remains to be explored. The prospective China Kadoorie Biobank study included 0.

Comparison of models to predict incident chronic liver disease: a systematic review and external validation in Chinese adults.

Background: Risk prediction models can identify individuals at high risk of chronic liver disease (CLD), but there is limited evidence on the performance of various models in diverse populations. We aimed to systematically review CLD prediction models, meta-analyze their performance, and externally validate them in 0.5 million Chinese adults in the China Kadoorie Biobank (CKB).

Dual-plasmonic eccentric nanostructure with prominent colorimetric and photothermal performance to detect zearalenone by dual signal immunochromatography assay.

In the study, an eccentric heterogeneous core-shell nanomaterial Au@CuSe was simply and rapidly synthesized. This novel nano-structure exhibits superior colorimetric intensity, enhanced antibody coupling efficiency, and strong broadband absorption across the visible to near-infrared spectrum, with a photothermal conversion efficiency of 59.40%.

A Cell-Based Electrochemical Biosensor for the Detection of Infectious Hepatitis A Virus.

Hepatitis A virus (HAV), a major cause of acute liver infections, is transmitted through the fecal-oral route and close contact with infected individuals. Current HAV standardized methods rely on the detection of virus antigen or RNA, which do not differentiate between infectious and non-infectious HAV. The objective of this study was to develop a prototype cell-based electrochemical biosensor for detection of infectious HAV.

A Milk Extracellular Vesicle-Based Nanoplatform Enhances Combination Therapy Against Multidrug-Resistant Bacterial Infections.

The increasing occurrence of infections caused by multidrug-resistant (MDR) bacteria drives the need for new antibacterial drugs. Due to the current lack of antibiotic discovery and development, new strategies to fight MDR bacteria are urgently needed. Efforts to develop new antibiotic adjuvants to increase the effectiveness of existing antibiotics and design delivery systems are essential to address this issue.

Isolation and Characterization of Probiotic Bacteria from Traditional Foods.

A probiotic is a live bacterium that, when given in sufficient proportions, helps to improve the host's gut health. Kimchi and pearl millet, two traditional foods, were used to isolate probiotic bacterial strains. This study's primary goals were to isolate, identify and analyse the microorganisms for potential probiotic traits, tolerance to gastrointestinal environments, and antimicrobial activity, and produce probiotic capsule.

Comparative efficacy of anaerobic digestion systems in removing antimicrobial resistance genes from swine wastewater.

Swine farm wastewater is a major reservoir of antimicrobial resistance genes (ARGs). Anaerobic digestion (AD), widely implemented in farms, has been extensively studied for ARG removal. However, a comparative study on ARG removal efficiency across the four principal AD systems - up-flow anaerobic sludge blanket (UASB), continuous stirred tank reactor (CSTR), buried biogas digester (BBD), and septic tank (SPT) - is lacking.