4 results match your criteria: "Center for Family Health Research Zambia[Affiliation]"
Female Genital Schistosomiasis Lesion Resolution Post-Treatment with Praziquantel in Zambian Adults.
Am J Trop Med Hyg
February 2024
Rwanda Zambia HIV Research Group, Department of Pathology & Laboratory Medicine, School of Medicine and Hubert Department of Global Health, Rollins School of Public Health, Laney Graduate School, Emory University, Atlanta, Georgia.
We evaluated changes in female genital schistosomiasis (FGS) 6 to 12 months after praziquantel treatment among 43 adult Zambian women. Most women (60%) experienced decreased FGS severity and 23% experienced complete lesion resolution. This is the first study to demonstrate a meaningful effect of praziquantel treatment of FGS in adult women.
View Article and Find Full Text PDFAuthor Correction: Africa-specific human genetic variation near CHD1L associates with HIV-1 load.
Nature
September 2023
Global Health Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
Africa-specific human genetic variation near CHD1L associates with HIV-1 load.
Nature
August 2023
Global Health Institute, School of Life Sciences, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
HIV-1 remains a global health crisis, highlighting the need to identify new targets for therapies. Here, given the disproportionate HIV-1 burden and marked human genome diversity in Africa, we assessed the genetic determinants of control of set-point viral load in 3,879 people of African ancestries living with HIV-1 participating in the international collaboration for the genomics of HIV. We identify a previously undescribed association signal on chromosome 1 where the peak variant associates with an approximately 0.
View Article and Find Full Text PDFCohort-Specific Peptide Reagents Broaden Depth and Breadth Estimates of the CD8 T Cell Response to HIV-1 Gag Potential T Cell Epitopes.
Vaccines (Basel)
February 2023
Center for Family Health Research Zambia, PostNet 412, P/Bag E891, B22/737 Bwembelelo, Emmasdale, Lusaka 10101, Zambia.
Article Synopsis
- * Researchers analyzed CD8 T-cell responses from twenty-six HIV-1 positive donors at one year post-infection using various peptide reagents that represent different HIV sequences.
- * Results show that both global and cohort-specific peptides offer broader coverage of epitopes compared to traditional consensus peptides, potentially enhancing the understanding of the immune response to HIV-1 and guiding future vaccine strategies.