273 results match your criteria: "Center for Epidemiology and Statistics[Affiliation]"

Barriers to influenza vaccination during pregnancy in France: A national population-based study.

Vaccine

January 2025

Maternité Port-Royal, Groupe hospitalier Paris Centre, AP-HP, FHU Prema, 75014 Paris, France; Université Paris Cité, Paris, France; INSERM UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (Epopé), Center for Epidemiology and Statistics, Université de Paris-Cité, Paris, France.

Background: Despite French national recommendations since 2012 that all pregnant women be vaccinated against influenza, in 2021 this vaccine coverage is low - around 30 % - in France.

Objectives: To identify barriers to influenza vaccination during pregnancy by assessing how often women were offered this vaccination and how often they accepted it.

Study Design: We used data from the French national perinatal survey (ENP), which covered all births during one week in March 2021 (N = 12,614).

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Impact of gender on self-assessment accuracy among fourth-year French medical students on faculty's online Objective Structured Clinical Examinations.

BMC Med Educ

December 2024

Department of Infectious and Tropical Diseases, Hôpital Saint-Louis Et Lariboisière, AP-HP, Université Paris Cité, 1 Avenue Claude Vellefaux, Paris, F-75010, France.

Background: Historically, women have been shown to underestimate their abilities, while men often assess themselves more accurately or overestimate. This study aims to determine self-assessment accuracy during online Objective Structured Clinical Examinations (OSCEs) according to gender.

Methods: A prospective study was conducted among fourth-year medical students at Paris Cité University during faculty training OSCEs, utilizing Zoom® software for remote participation.

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The aim of the study was to elucidate predictors associated with the initial choice of vascular access (VA) type. The secondary aim was to determine the initial VA's median utilization time and the factors governing it. This prospective cohort study included 387 hemodialysis (HD) patients admitted to the Clinic for Hemodialysis, Clinical Center University of Sarajevo, in consecutive order between January 2006 and December 2016.

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Maternal and Neonatal Consequences of Early Augmentation of Labor Among Women With Spontaneous Onset of Labor: A National Population-Based Study.

Birth

September 2024

INSERM UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (Epopé), Center for Epidemiology and Statistics, FHU PREMA, Université de Paris, Paris, France.

Article Synopsis
  • A study investigated early augmentation of labor (EAL) and its impact on cesarean delivery rates, postpartum hemorrhage, and neonatal outcomes among women in France.
  • Among 7,196 women studied, 21.2% underwent EAL, which was linked to a higher cesarean delivery rate of 8.40% compared to 6.15% in the non-EAL group.
  • However, EAL did not lead to significant differences in severe postpartum hemorrhage or adverse neonatal outcomes, suggesting its primary concern is increased cesarean deliveries.
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Maintenance oxytocin in the immediate postpartum period: Frequency, determinants and practices in a tertiary maternity unit.

J Gynecol Obstet Hum Reprod

May 2024

Department of Obstetrics and Gynecology of Port-Royal, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, Paris University, Paris, France. Electronic address:

Objective: To prevent post-partum haemorrhage (PPH), national and international guidelines recommend the administration of a prophylactic injection of oxytocin after all vaginal births. Although additional maintenance oxytocin is not recommended in the immediate postpartum, its administration is quite common (30 % of French births in 2021). To assess in a single center, the frequency and determinants associated with the administration of maintenance oxytocin in immediate postpartum.

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Prevalence of COVID-19 among pregnant women and its impact on childbirth in March 2021: Data from the French National Perinatal Survey.

J Gynecol Obstet Hum Reprod

April 2024

Maternité Port-Royal, Groupe hospitalier Paris Centre, AP-HP, FHU Prema, 75014 Paris, France; INSERM UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (Epopé), Center for Epidemiology and Statistics, Université de Paris-Cité, Paris, France.

Article Synopsis
  • * COVID-19 prevalence in pregnant women was found to be 5.7%, with multiple factors influencing diagnosis, such as non-French nationality and multiparity.
  • * Women diagnosed with COVID-19 during pregnancy experienced higher rates of preterm births and cesarean deliveries, especially those diagnosed shortly before childbirth.
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Identifying Newborns with Hypoxic-Ischemic Encephalopathy in Hospital Discharge Data: A Validation Study.

J Pediatr

May 2024

INSERM UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (EPOPé), Center for Epidemiology and Statistics Sorbonne Paris Cité (CRESS), FHU PREMA, Paris Descartes University, Paris, France.

Hospital discharge databases (HDDs) are increasingly used for research on health of newborns. Linkage between a French population-based cohort of newborns with hypoxic-ischemic encephalopathy (HIE) and national HDD showed that the HIE ICD-10 code was not accurately reported. Our results suggest that HDD should not be used for research on neonatal HIE without prior validation of HIE ICD-10 codes.

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Pregnancy outcomes in women with primary Sjögren's syndrome: an analysis of data from the multicentre, prospective, GR2 study.

Lancet Rheumatol

June 2023

APHP, Hôpital Bicêtre, Service de Rhumatologie, Centre de Référence Maladies Auto-Immunes et Systémiques Rares d'Île-de-France, Inserm UMR 1184, Center for Immunology of Viral Infections and Autoimmune Diseases, Université Paris-Saclay, Le Kremlin-Bicêtre, France. Electronic address:

Background: Adverse pregnancy outcomes in women with primary Sjögren's syndrome have only been evaluated retrospectively using heterogeneous methods and with contradictory results. We aimed to describe adverse pregnancy, delivery, and birth outcome risks in pregnant women with primary Sjögren's syndrome compared with those of a matched general population in France, and to identify factors predictive of disease flares or adverse pregnancy outcomes.

Methods: We conducted a multicentre, prospective, cohort study in France using the GR2 (Groupe de Recherche sur la Grossesse et les Maladies Rares) registry.

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Assessing the external validity and clinical relevance of umbilical doppler resistance index references in daily practice.

J Gynecol Obstet Hum Reprod

February 2024

Port-Royal Maternity Unit, Department of Obstetrics, FHU PREMA, Cochin Broca Hôtel-Dieu Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris F-75014, France; INSERM UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (Epopé), Center for Epidemiology and Statistics, FHU PREMA, Clinical Research Unit of Paris Descartes Necker Cochin, Université de Paris, Paris, France, APHP, Paris, France.

Objective: To assess the external validity and clinical relevance of current references for umbilical artery resistance index (UA RI) in daily practice.

Methods: Retrospective cross-sectional single center study including all UA RI measurements between 22 and 40 gestational weeks (GW) from distinct patients between 2014 and 2022. Patients with normal pregnancies and normal neonatal outcomes that had an UA RI measurement between 2014 and 2019 were used to calculate reference ranges.

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Article Synopsis
  • The study examined the use of inhaled nitric oxide (iNO) for treating very preterm infants (born at 22 to 31 weeks) across 11 European countries from 2011 to 2012.
  • Out of 7268 infants, 292 received iNO treatment, revealing significant variations in treatment rates between countries, with higher in-hospital mortality rates for those treated with iNO compared to matched controls.
  • Despite the increased mortality during hospitalization, long-term follow-up of 5 years showed no significant risk of neurodevelopmental impairments in the survivors treated with iNO.
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Background: The value of formative objective structured clinical examinations (OSCEs) during the pre-clinical years of medical education remains unclear. We aimed to assess the effectiveness of a formative OSCE program for medical students in their pre-clinical years on subsequent performance in summative OSCE.

Methods: We conducted a non-randomized controlled prospective pilot study that included all medical students from the last year of the pre-clinical cycle of the Université Paris-Cité Medical School, France, in 2021.

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Screening for small for gestational age infants in early vs late third-trimester ultrasonography: a randomized trial.

Am J Obstet Gynecol MFM

November 2023

Department of Obstetrics and Gynecology, Rouen University Hospital, Rouen, France (Drs Verspyck, Brasseur-Daudruy, Braund, and Benichou); Inserm U1018, University of Rouen and University Paris-Saclay, Rouen, France (Dr Benichou); Department of Biostatistics, Rouen University Hospital, Rouen, France (Dr Benichou).

Background: Recent studies have demonstrated that a routine third-trimester ultrasound scan may improve the detection of small for gestational age infants when compared with clinically indicated ultrasound scans but with no reported reduction in severe perinatal morbidity. Establishing the optimal gestational age for the third-trimester examination necessitates evaluation of the ability to detect small for gestational age infants and to predict maternal and perinatal outcomes. Intrauterine growth restriction most often corresponds with small for gestational age infants associated with pathologic growth patterns.

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Risk of disseminated intravascular coagulation in postpartum hemorrhage associated with intrauterine infection.

J Gynecol Obstet Hum Reprod

October 2023

Department of Obstetrics and Gynecology of Port Royal, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, France. Paris Cité University, Paris, France. Electronic address:

Objective: To evaluate the risk of disseminated intravascular coagulation (DIC) in postpartum hemorrhage (PPH) associated with intrauterine infection.

Material And Methods: A retrospective cohort study of pregnancies complicated by PPH performed at a tertiary academic center in France from 2017 through 2021. Patients giving birth after 22 weeks of gestation with PPH were eligible.

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Publication rate and factors associated with publication of research projects by obstetrics residents in an academic department over 10 years.

Eur J Obstet Gynecol Reprod Biol

August 2023

Department of Obstetrics and Gynecology of Port-Royal, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, Paris University, Paris, France; Obstetrical Perinatal and Pediatric Epidemiology (Epopé) Research Team, Center for Epidemiology and Statistics (CRESS), INSERM U1153, Paris, France.

Objectives: To determine the publication rate of mandatory research projects conducted by obstetrics residents and to evaluate the publication-associated factors and reported obstacles.

Study Design: This retrospective cohort study included all consecutive residents in an academic obstetrics-gynecology department in Paris, France, between 2010 and 2020. All residents were required to conduct a research project.

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Azathioprine-induced vanishing bile duct syndrome: The value of early thiopurine metabolism assessment.

Br J Clin Pharmacol

August 2023

Unité de Pharmacogénétique, Service de Biochimie, Hôpital européen Georges Pompidou, AP-HP.Centre, Université Paris Cité, Paris, France.

Article Synopsis
  • A 34-year-old woman on azathioprine for lupus developed serious liver problems, leading to a diagnosis of ductopenia after blood tests showed abnormal metabolite levels.
  • The case highlights the rarity of ductopenia as a side effect of azathioprine and suggests that monitoring blood levels of thiopurine metabolites could help identify patients at risk of liver damage.
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Comment on "Trends and disparities in breastfeeding initiation in France between 2010 and 2016: Results from the French National Perinatal Surveys".

Matern Child Nutr

July 2023

Inserm U1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (Epopé), Center for Epidemiology and Statistics-Paris University, DHU Risks in Pregnancy, Paris Descartes University, Paris, France.

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Implementation of glucose 5% supplementation protocol to reduce the duration of labor among women with cervical ripening by prostaglandins: The GLUCOSHORT before-and-after study.

J Gynecol Obstet Hum Reprod

May 2023

Port-Royal maternity unit, Department of Obstetrics, Cochin Broca Hôtel-Dieu hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), FHU PREMA, F-75014, Paris, France; INSERM UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (Epopé), Center for Epidemiology and Statistics, FHU PREMA, Université de Paris, Paris, France.

Introduction: Previous publications have shown that glucose supplementation could reduce labor duration in women with induction of labor with a favorable cervix but none have shown it for women with an unfavorable cervix.  The purpose of our study was to assess the impact on labor duration of a protocol of glucose supplementation used for induction of labor in women with an unfavorable cervix.

Material And Methods: The protocol implemented in November 2017 added glucose supplementation by 5% dextrose at 125 mL/h to Ringer lactate for women with an unfavorable cervix with labor induced with dinoprostone gel.

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Precipitating factors of catastrophic antiphospholipid syndrome: the role of anticoagulant treatment in a series of 112 patients.

J Thromb Haemost

May 2023

Internal Medicine Department, AP-HP, Referral Center for Rare Autoimmune and Systemic Diseases of Ile de France, Cochin Hospital, Paris, France; Université Paris Cité, Center for Epidemiology and Statistics, Institut national de la santé et de la recherche médicale, French National Institute for Agricultural Research, Paris, France. Electronic address:

Background: The prevention of catastrophic antiphospholipid syndrome (CAPS), a rare complication of antiphospholipid syndrome (APS), is a major goal.

Objectives: We analyzed its precipitating factors, focusing on anticoagulation immediately before CAPS episodes.

Methods: We retrospectively analyzed patients in the French multicenter APS/systemic lupus erythematosus database with at least 1 CAPS episode.

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Effectiveness of episiotomy to prevent OASIS in nulliparous women at term.

Int J Gynaecol Obstet

August 2023

Department of Obstetrics and Gynecology, Robert Debré Hospital, APHP, Paris, France.

Objective: To assess the association between episiotomy and severe obstetric anal sphincter injury (OASIS) in nulliparous women at term according to the use of an instrument for delivery with control confounding by indication.

Methods: This was an observational retrospective cohort study including 12 346 women from 2004 to 2020. All nulliparous women with a cephalic singleton pregnancy were included.

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Our understanding of the various aspects of pregnancy in women with kidney diseases has significantly improved in the last decades. Nevertheless, little is known about specific kidney diseases. Glomerular diseases are not only a frequent cause of chronic kidney disease in young women, but combine many challenges in pregnancy: immunologic diseases, hypertension, proteinuria, and kidney tissue damage.

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Article Synopsis
  • The study analyzed data from various birth defect surveillance programs across 18 countries to assess the prevalence and mortality rates of anorectal malformation (ARM) between 1974 and 2014.
  • The overall prevalence of ARM was found to be 3.26 cases per 10,000 births, with a notable decrease in cases that were multiple, syndromic, or stillborn from 2001 to 2012.
  • The research highlights a significant mortality risk during the first week of life, especially in multiple and syndromic cases, suggesting a need for tailored clinical services and further investigation into factors affecting ARM prevalence and mortality.
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Hydroxychloroquine dose: balancing toxicity and SLE flare risk.

Nat Rev Rheumatol

January 2023

Department of Internal Medicine, Centre de Référence Maladies Auto-Immunes et Systémiques Rares d'Ile de France, Cochin Hospital, AP-HP, Paris, France.

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Risk factors for hypoxic-ischemic encephalopathy or neonatal death in placental abruption.

J Gynecol Obstet Hum Reprod

January 2023

Department of Obstetrics and Gynecology of Port Royal, Cochin Hospital, Assistance Publique-Hôpitaux de Paris, Paris University, Paris, France. Electronic address:

Objective: To identify risk factors for moderate or severe hypoxic-ischemic encephalopathy (HIE), or neonatal death in clinical placental abruption.

Material And Methods: A nested case-control study within a cohort of singleton pregnancies complicated by placental abruption with a live born infant at two academic reference centers in France, from 2006 to 2019. Cases were patients who gave birth to an infant with moderate or severe HIE or death within 28 days (HIE/death group), and controls were patients whose infant did not have any of these outcomes (no-HIE group).

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Evaluating the quality of care for postpartum hemorrhage with a new quantitative tool: a population-based study.

Sci Rep

November 2022

Université Paris Cité, Obstetrical, Perinatal and Pediatric Epidemiology (Epopé) Research Team, Center for Epidemiology and Statistics (CRESS), INSERM U1153, Maternité Port Royal, 53 avenue de l'observatoire, 75014, Paris, France.

To develop a new tool to assess the global quality of care for post-partum hemorrhage (PPH)-the leading preventable cause of maternal mortality worldwide-and to identify characteristics of maternity units associated with inadequate PPH management. This is a secondary analysis of the EPIMOMS population-based study conducted in 2012-2013 in 119 french maternity units (182,309 women who gave birth). We included women with severe PPH.

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Article Synopsis
  • Bladder exstrophy (BE) is a rare birth defect impacting the lower abdomen; this study investigates its prevalence, trends, and age-specific mortality rates using data from 20 surveillance programs across 16 countries from 1974 to 2014.
  • The overall prevalence of BE was found to be 2.58 cases per 100,000 births, with a noticeable decline in prevalence between 2000 and 2014; first-week mortality rates were particularly high for multiple and syndromic cases, especially among cases from Latin America lacking elective termination options.
  • The findings emphasize the importance of monitoring prevalence trends and addressing the elevated mortality risks in affected individuals, particularly in specific regions and among certain case
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