Predicting few disinfection byproducts in the water distribution systems using machine learning models.

Concerns regarding disinfection byproducts (DBPs) in drinking water persist, with measurements in water treatment plants (WTPs) being relatively easier than those in water distribution systems (WDSs) due to accessibility challenges, especially during adverse weather conditions. Machine learning (ML) models offer improved predictions of DBPs in WDSs. This study developed multiple ML models to predict Trihalomethanes (THMs), Haloacetic Acids (HAAs), Dichloroacetonitrile (DCAN), and N-nitrosodimethylamine (NDMA) in WDSs using data collected over 13 years (2008-2020) from 113 water supply systems (WSS) in Ontario.

[Statistical methods for extremely unbalanced data in genome-wide association study (2)].

Extremely unbalanced data refers to datasets with independent or dependent variables showing severe imbalances in proportions, which might lead to deviation of classical test statistics from theoretical distribution and difficulties in controlling type Ⅰ error. The increased availability of genome-wide resources from large population cohorts has highlighted the growing demand for efficient and accurate statistical methods for the process of extremely unbalanced data to improve the development of genetic statistical methods. This paper introduces two widely used correction methods in current genome-wide association study for extremely unbalanced data, i.

Prediction of Potential Risk for Ten Azole and Benzimidazole Fungicides with the Aryl Hydrocarbon Receptor Agonistic Activity to Aquatic Ecosystems.

Azole and benzimidazole fungicides are widely used agrochemicals to prevent and treat fungal growth and are frequently detected in aquatic environments. Here, we aimed to assess the aquatic ecological risks of ten currently used azole and benzimidazole fungicides, which with the aryl hydrocarbon receptor (AhR) agonistic activity, and their transformation products (TPs). We obtained over 400 types of aerobic TPs for ten fungicides.

Parental occupational exposure to anticancer drugs and radiation: Risk of fetal loss and physical abnormalities in The Japan Environment and Children's Study.

Background: Many studies have indicated an association between maternal occupational exposure to hazardous agents, such as anticancer drugs and ionizing radiation, and an increased risk of adverse pregnancy outcomes, including stillbirths or miscarriages and physical abnormalities in offspring. However, the effects of recent advancements in protective measures to reduce these risks have not been clarified. Aim To investigate the current impact of parental occupational exposure to anticancer drugs and ionizing radiation on stillbirths or miscarriages as well as physical abnormalities under the circumstances of the developed safety protocols.

Halogenated organic compounds in mangrove sediments from Bintan Island, Indonesia: Occurrence, profiles, sources, and potential ecological risk.

The first comprehensive analysis of halogenated organic compounds (HOCs), including 209 full congeners of polychlorinated biphenyls (PCBs), 26 organochlorinated pesticides (OCPs), 41 polybrominated diphenyl ethers (PBDEs), and four other brominated flame retardants (BFRs), was performed on surface mangrove sediments from Bintan Island, Province of the Riau Archipelago, Indonesia. Among the measured HOC contaminants, the mean concentration of ∑PCBs (2.3 ± 0.

Development, Validation, and Visualization of a Web-Based Nomogram to Predict the Risk of Psychological Distress in Patients Undergoing Chemotherapy After Breast Cancer Surgery.

Background: Psychological distress of postoperative chemotherapy patients with breast cancer is significant and has a serious impact on their quality of survival. Risk prediction models can efficiently assess patients' psychological distress and risk factors.

Objectives: To investigate the factors influencing psychological distress in postoperative chemotherapy patients with breast cancer and construct a nomogram model to predict the occurrence of psychological distress in patients.

Age-Stage, Two-Sex Life Tables of (Bagnall) and (Trybom) on Different Bean Pods Under Laboratory Conditions: Implications for Their Competitive Interactions.

As two major pests of cowpea in South China, bean flower thrips [ (Bagnall)] and flower thrips [ (Trybom)] always occur on the same plant. In this study, the two-sex life table parameters of these two species were investigated on three bean pods: cowpea ( L. var.

RNAi of Neuropeptide CCHamide-1 and Its Receptor Indicates Role in Feeding Behavior in the Pea Aphid, .

Neuropeptide (abbreviated as ) is a recently discovered peptide that is present in many arthropods and is the ligand of the , a member of the G protein-coupled receptors (GPCRs) superfamily, which plays a regulatory role in diverse physiological processes such as feeding, circadian rhythm, insulin production, lipid metabolism, growth, and reproduction. However, the function of this gene in aphids is still unknown. Here, we characterized and determined the potential role of / signaling in the pea aphid, , which is a notorious pest in agriculture.

Lysoglycerophospholipid metabolism alterations associated with ambient fine particulate matter exposure: Insights into the pro-atherosclerotic effects.

The biological pathways connecting ambient fine particulate matter (PM)-induced initial adverse effects to the development of atherosclerotic cardiovascular diseases are not fully understood. We hypothesize that lysoglycerophospholipids (LysoGPLs) are pivotal mediators of atherosclerosis induced by exposure to PM. This study investigated the changes of LysoGPLs in response to PM exposure and the mediation role of LysoGPLs in the pro-atherosclerotic effects of PM exposure.

Regulating Supramolecular Assembly and Disassembly of Chitosan toward Efficiently Antibacterial Lubricous and Biodegradable Hydrogel Urinary Catheters.

Urinary catheters serve as critical medical devices in clinical practice. However, the currently used urinary catheters lack efficient antibacterial and lubricating properties, often leading to discomfort with patients and even severe urinary infections. Herein, a new strategy of supramolecular assembly and disassembly of chitosan (Cs) is developed that enables efficient antibacterial lubricous and biodegradable hydrogel urinary catheters.

Estimating the Risk of Women Anemia Associated with Ozone Exposure Across 123 Low- and Middle-Income Countries: A Multicenter Epidemiological Study.

Anemia in women of reproductive age (WRA) presents a pressing global public health issue, particularly in low- and middle-income countries (LMICs). Yet, the potential impact of ozone (O) exposure on anemia remains uncertain. The study included 1,467,887 eligible women from 83 surveys of 45 LMICs between 2004 to 2020.

Albizia Procera-Derived Nitrogen-Doped Carbon: A Versatile Material for Energy Conversion, Storage, and Environmental Applications.

This review explores the diverse applications of nitrogen-doped carbon derived from Albizia procera, known as white siris. Native to the Indian subcontinent and tropical Asia, this species thrives in varied conditions, contributing to sustainable development. The nitrogen-rich leaves of Albizia procera are an excellent source for synthesizing nitrogen-doped carbon, which possesses remarkable properties for advanced technologies.

Cost-Effectiveness Analysis of Vaccination Compliance Strategies Using a Novel Hybrid Model for Influenza Vaccination.

Introduction: The cost-effectiveness of vaccination strategies plays a crucial role in managing infectious diseases such as influenza within public health systems. This study evaluated the cost-effectiveness of vaccination compliance strategies by comparing an "adherence" strategy, which promoted continuous vaccination uptake, with a "volunteer" strategy through model-based simulations.

Methods: We developed a novel hybrid model that integrates continuous-time agent-based models (ABMs) with a Markov model to simulate vaccination behaviors and disease dynamics at the individual level.

The 2023 report of the synergetic roadmap on carbon neutrality and clean air for China: Carbon reduction, pollution mitigation, greening, and growth.

The response to climate change and air pollution control demonstrates strong synergy across scientific mechanisms, targets, strategies, and governance systems. This report, based on a monitoring indicator system for coordinated governance of air pollution and climate change, employs an interdisciplinary approach combining natural and social sciences. It establishes 20 indicators across five key areas: air pollution and climate change, governance systems and practices, structural transformation and technologies, atmospheric components and emission reduction pathways, and health impacts and co-benefits.

Light-Driven Adaptive Molecular Crystals Activated by [2+2] and [4+4] Cycloadditions.

Photomechanical crystals act as light-driven material-machines that can convert the energy carried by photons into kinetic energy via shape deformation or displacement, and this capability holds a paramount significance for the development of photoactuated devices. This transformation is usually attributed to anisotropic expansion or contraction of the unit cell engendered by light-induced structural modifications that lead to accumulation and release of stress that generates a momentum, resulting in readily observable mechanical effects. Among the available photochemical processes, the photoinduced [2+2] and [4+4] reactions are known for their robustness, predictability, amenability to control with molecular and supramolecular engineering approaches, and efficiency that has already been elevated to a proof-of-concept smart devices based on organic crystals.

Health-Oriented Strategy for Clean Air and Climate Actions: Differential Health Effects of Atmospheric Components.

Health is at the forefront of clean air and climate action. However, most existing studies of health impacts were based on additive single-exposure effects, which often oversimplify the relationships between atmospheric components and health outcomes. This review examines various atmospheric components' common sources and differential health effects, including greenhouse gases and major air pollutants such as fine particulate matter (PM).

Novel Genetic Loci Associated with PhenoAge Acceleration - Changzhou City, Jiangsu Province, China, 2012-2019.

What Is Already Known About This Topic?: China is rapidly encountering population aging, yet studies on aging are limited by the traditional aging measure: chronological age, particularly in the field of genomics. Several promising aging measures have been proposed, but they lack comparative evaluation.

What Is Added By This Report?: PhenoAge was identified as a measure of aging that demonstrated greater applicability in contemporary populations.

Andean bears (Tremarctos ornatus) display selective behaviors while foraging bromeliads (Puya spp.) in high elevation puna grasslands.

Andean bears (Tremarctos ornatus) forage extensively on bromeliads (Puya spp.) across their range, although their selectivity for bromeliads is less understood. We report on foraging activity by Andean bears on two species of bromeliad, Puya leptostachya and Puya membranacea, in high elevation puna grasslands (3499-3806 m.

Exploring the Allelic Diversity of the Self-Incompatibility Gene Across Natural Populations in Petunia (Solanaceae).

Self-incompatibility (SI) is a genetic mechanism to prevent self-fertilization and thereby promote outcrossing in hermaphroditic plant species through discrimination of self and nonself-pollen by pistils. In many SI systems, recognition between pollen and pistils is controlled by a single multiallelic locus (called the S-locus), in which multiple alleles (called S-alleles) are segregating. Because of the extreme level of polymorphism of the S-locus, identification of S-alleles has been a major issue in many SI studies for decades.

A Comparative Analysis on Indoor and Outdoor PM and Their Hourly Associations with Acute Respiratory Inflammation Among College Students in Lhasa.

Ambient concentrations are commonly used as proxies for personal PM exposure in epidemiological studies, despite indoor settings being the places where people spend most of their time. In a panel study of 110 nonsmoking, healthy college students in Lhasa, Tibet, indoor PM was monitored using calibrated low-cost sensors for two multiweek periods, in over 40 dormitories where participants resided. We also repeatedly measured fractional exhaled nitric oxide (FeNO), an acute respiratory inflammation biomarker, for each participant.

FolSas2 is a regulator of early effector gene expression during Fusarium oxysporum infection.

Fusarium oxysporum f. sp. lycopersici (Fol) that causes a globally devastating wilt disease on tomato relies on the secretion of numerous effectors to mount an infection, but how the pathogenic fungus precisely regulates expression of effector genes during plant invasion remains elusive.