2 results match your criteria: "Center for Engineered Systems[Affiliation]"
A SPLUNC1 Peptidomimetic Inhibits Orai1 and Reduces Inflammation in a Murine Allergic Asthma Model.
Am J Respir Cell Mol Biol
March 2022
Department of Cell Biology and Physiology.
Article Synopsis
- Orai1 is a calcium channel that plays a key role in regulating inflammation and store-operated calcium entry (SOCE), whereas SPLUNC1 is a gene modifier related to asthma that inhibits Orai1's function.
- In asthma models, researchers found that inhaling α6 peptidomimetics, derived from SPLUNC1, could lower Orai1 levels and reduce immune cell responses linked to inflammation.
- The study revealed that α6 effectively decreased eosinophil and neutrophil counts in mice exposed to allergens, suggesting it could be a promising new treatment for asthma.
Designing inhalable metal organic frameworks for pulmonary tuberculosis treatment and theragnostics via spray drying.
Chem Commun (Camb)
November 2020
Center for Engineered Systems, RTI International, USA.
Inhalable metal organic framework (MOF) aerosols have been developed via spray drying as a therapy for multi-drug resistant (MDR) tuberculosis (TB). The CuPOA (pyrazinoate acid) MOFs can be tailored to exhibit a respirable mass median aerodynamic diameter (MMAD) of 2.6 μm.
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