1 results match your criteria: "Center for Drug and Evaluation and Research[Affiliation]"
Absorption, distribution, and excretion of ammonium perfluorooctanoate (APFO) after oral administration to various species.
Drug Chem Toxicol
July 2006
Food and Drug Administration, Center for Drug and Evaluation and Research, Rockville, Maryland, USA.
Male and female mice, rats, hamsters, and rabbits were treated with a single oral dose of 14C-ammonium perfluorooctanoate (APFO), and the excretion and tissue distributions were followed for 120 h (168 h in the rabbit). Substantial sex and species differences in the excretion and disposition of 14C-radioactivity derived from 14C-labeled APFO were observed in this study. The female rat and the male hamster excreted more than 99% of the original 14C activity by 120 h after dosing; conversely, the male rat and the female hamster excreted only 39% and 60% of the original 14C activity, respectively, by 120 h postdosing.
View Article and Find Full Text PDF