2 results match your criteria: "Center for Drug Evaluation of China[Affiliation]"

Article Synopsis
  • Researchers are urgently seeking alternative treatments for diabetes due to the serious complications it can cause, including kidney issues.
  • The study tested polysaccharides from AAP on diabetic rats, comparing its effects to metformin, finding that AAP significantly lowered blood glucose levels and showed antioxidant benefits.
  • AAP demonstrated protective effects against diabetic nephropathy by regulating various blood parameters and influencing pathways associated with oxidative stress, suggesting it could be a promising new treatment for diabetes.
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Aim: To synthesize acylated prodrug of tacrine hydrochloride (THA) to improve the infiltration ability across the blood brain barrier (BBB).

Methods: A series of prodrugs were prepared by acylation of the 7-amino group of THA. The degradation of prodrugs was investigated under different conditions.

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