157 results match your criteria: "Center for Clinical Informatics Research and Education[Affiliation]"

Background: Risk factors for gluteal tears include age-related deterioration, female sex, and increased body mass index. As the literature that supports the sagittal relationship between the lumbar spine and the hip is increasing, there may be a parallel relationship between the perturbations in spinopelvic alignment caused by lumbar spine disease and gluteal muscle tears. Because no prior studies other than single-institution series have reported on this phenomenon, we investigated spine-abductor syndrome at the population level.

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Background: The growing popularity of glucagon-like peptide-1 receptor agonists (GLP-1-RAs) for weight loss could significantly impact joint preservation and arthroplasty. While this will in part be driven by the association between obesity, osteoarthritis (OA), and total joint arthroplasty (TJA), recent evidence also indicates that GLP-1-RAs may have direct joint-protective, anti-inflammatory effects.

Purpose: To evaluate the association between GLP-1-RA use and the onset and progression of hip and knee OA in an obese population.

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Background And Objectives: Electronic health record (EHR) customization is proposed to mitigate EHR-related burnout. Gender disparities in EHR usage are established, though less is known regarding differences in customization and its impact on EHR time. This study examined gender differences in vendor-derived proficiency score (PS) and its relationship to EHR time.

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Electronic health records (EHRs), though they are maintained and utilized for clinical and billing purposes, may provide a wealth of information for research. Currently, sources are available that offer insight into the health histories of well over a quarter of a billion people. Their use, however, is fraught with hazards, including introduction or reinforcement of biases, clarity of disease definitions, protection of patient privacy, definitions of covariates or confounders, accuracy of medication usage compared with prescriptions, the need to introduce other data sources such as vaccination or death records and the ensuing potential for inaccuracy, duplicative records, and understanding and interpreting the outcomes of data queries.

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Background: Preserved ratio impaired spirometry (PRISm) represents a population with spirometry results that do not meet standardized COPD obstruction criteria, yet present with high respiratory symptom burden and might benefit from respiratory management and treatment. We aimed to determine prevalence of PRISm in US primary care patients diagnosed with COPD, describe their demographic, clinical, and CT scan characteristics.

Methods: An observational registry study utilizing the US APEX COPD registry, composed of patients diagnosed with COPD aged 35+ years.

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Idiopathic Intracranial Hypertension Is Associated With an Increased Risk of Hypertensive Pregnancy Disorders.

J Neuroophthalmol

December 2024

Department of Population and Quantitative Health Sciences (JKS), Case Western Reserve University, Cleveland, Ohio; Case Western Reserve School of Medicine (JKS, IT, TA, JR, JC), Cleveland, Ohio; Center for Ophthalmic Bioinformatics (JKS, RPS, KET), Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio; Departments of Internal Medicine, Pediatrics, and Population and Quantitative Health Sciences (DCK), Case Western Reserve University, Cleveland, Ohio; The Center for Clinical Informatics Research and Education (DCK), The MetroHealth System, Cleveland, Ohio; Cleveland Clinic Cole Eye Institute (RPS, KET, DAC), Cleveland, Ohio; Cleveland Clinic Lerner College of Medicine of Case Western Reserve University (RPS, KET, DAC), Cleveland Ohio; and Cleveland Clinic Martin Hospitals (RPS), Cleveland Clinic, Stuart, FL.

Article Synopsis
  • Idiopathic intracranial hypertension (IIH) primarily affects overweight or obese women of reproductive age, making it crucial to investigate its relationship with pregnancy.
  • A study examined the incidence of IIH development during pregnancy and its association with hypertensive disorders, finding that 7% of IIH patients experienced new onset IIH during their pregnancies.
  • IIH patients had significantly higher risks for various hypertensive disorders like eclampsia, preeclampsia, and HELLP syndrome, as well as complications like ectopic pregnancies and miscarriages, even when controlling for obesity and migraine factors.
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Introduction: There are minimal evidence-based outcomes from clinical trials for medical-dental integration. This formative work and pilot study is a precursor to a larger cluster-randomized clinical trial in adult primary care practices to test an electronic health record (EHR) structured workflow for primary care providers (physicians/nurse practitioners [NPs]) and medical staff (medical assistants [MAs] and nurses) with oral health (OH) screening and referral for Medicaid-enrolled adults ≥55 years.

Methods: This study was conducted in 2 practices with providers, medical staff, and older adults.

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Article Synopsis
  • Amphetamine-type stimulants are widely used illicit drugs, and there's currently no FDA-approved treatment for related disorders, prompting researchers to explore repurposing existing drugs, particularly through AI models.
  • The study identified ketamine as a promising candidate for treating amphetamine-type stimulant use disorders and conducted research using electronic health records to assess its effectiveness.
  • Results indicated that ketamine was associated with a higher rate of remission in patients with amphetamine-type stimulant use disorders compared to other treatments, targeting specific neurological pathways linked to addiction.
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Intrapartum and 30-Day Postpartum Complications in Patients With Antenatal COVID-19 Infection: A Retrospective Cohort Study.

Infect Dis Obstet Gynecol

November 2024

Departments of Internal Medicine, Pediatrics, and Population and Quantitative Health Sciences, Case Western Reserve University, The Center for Clinical Informatics Research and Education, The MetroHealth System, Cleveland, Ohio 44106, USA.

The study was aimed at comparing intrapartum and postpartum outcomes between pregnant patients with and without antenatal COVID-19 infection using aggregated, deidentified electronic health record (EHR) data. This retrospective cohort study included data from over 80 health care organizations within the TriNetX Analytics Research Network. Individuals admitted for delivery from Jan 2020 to May 2023 were studied.

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Background: Recent research suggests that selective serotonin reuptake inhibitors (SSRIs) may reduce mortality in COVID-19 patients; however, research into their benefits for elderly Alzheimer's disease (AD) patients remains limited.

Objective: To investigate the relationship between SSRIs therapy and the mortality risk after COVID-19 infection in elderly patients with and without AD.

Methods: This retrospective cohort study leveraged a large database containing over 100 million electronic health records in the US from the TriNetX platform to compare the hazard rates of mortality after COVID-19 infection in elderly AD patients prescribed SSRIs versus propensity-score matched individuals prescribed other antidepressants.

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Importance: Racial disparities have been identified in pediatric community-acquired acute kidney injury (CA-AKI), and they are associated with increased risk of child mortality, morbidity, and progression of kidney disease.

Objective: To assess clinical outcomes at 1 year among children with CA-AKI, stratified by age, race, and ethnicity.

Design, Setting, And Participants: This retrospective cohort study is a population-based analysis of deidentified, aggregated electronic health record data collected by 61 large health care organizations from 2003 to 2023 and accessed through the TriNetX platform.

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Introduction: Emerging preclinical evidence suggests that semaglutide, a glucagon-like peptide receptor agonist (GLP-1RA) for type 2 diabetes mellitus (T2DM) and obesity, protects against neurodegeneration and neuroinflammation. However, real-world evidence for its ability to protect against Alzheimer's disease (AD) is lacking.

Methods: We conducted emulation target trials based on a nationwide database of electronic health records (EHRs) of 116 million US patients.

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Article Synopsis
  • The study investigates the link between glucagon-like peptide-1 receptor agonists (GLP-1RAs) and pancreatic cancer risk in patients with type 2 diabetes, focusing on factors like obesity and smoking.
  • It involved over 1.6 million patients and found that those using GLP-1RAs had a significantly lower incidence of pancreatic cancer compared to those using other diabetes medications, especially in patients with obesity and smoking issues.
  • The findings suggest that GLP-1RAs could reduce pancreatic cancer risk, and the combination therapies were more effective than single drug therapies; however, further research is needed to understand the underlying mechanisms.
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Article Synopsis
  • Diagnoses of new-onset type 2 diabetes (T2D) in children after COVID-19 infection were studied to see if they were more common than after other respiratory infections.
  • The study analyzed health records of over 600,000 pediatric patients aged 10-19, revealing a significant increase in T2D diagnoses within six months post-COVID-19 compared to those with other respiratory infections.
  • Specifically, the risk ratios (RR) showed that children infected with COVID-19 had a heightened risk of T2D, particularly noticeable in those with overweight/obesity and those who were hospitalized.
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Objective: To evaluate the effectiveness of Monocyte Distribution Width (MDW) in predicting sepsis outcomes in emergency department (ED) patients compared to other hematologic parameters and vital signs, and to determine whether routine parameters could substitute MDW in machine learning models.

Methods: We conducted a retrospective analysis of data from 10,229 ED patients admitted to a large regional safety-net hospital in Cleveland, Ohio who had suspected infections and developed sepsis-associated poor outcomes. We developed a new analytical framework consisting of seven data models and an ensemble of high accuracy machine learning (ML) algorithms (accuracy values ranging from 0.

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Racial and Ethnic Disparities in Prescription of a Novel Agent in Medical Management of Primary Open-Angle Glaucoma.

Ophthalmic Epidemiol

October 2024

Center for Ophthalmic Bioinformatics, Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio, USA.

Article Synopsis
  • The study aimed to analyze racial and ethnic disparities in the prescription of Netarsudil, a newer anti-glaucoma medication, among patients with primary open-angle glaucoma in the U.S.! -
  • Utilizing electronic health records from 92 million patients, the research revealed that White patients received more prescriptions of Netarsudil compared to Black and Hispanic patients, particularly in certain U.S. regions like the Midwest and South.! -
  • The findings highlighted significant differences in medication access based on race, emphasizing the need for further research to understand the root causes of these disparities and to promote equitable healthcare for all glaucoma patients.!
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Article Synopsis
  • The study utilized a large database to analyze the effects of serotonergic antidepressants on patient outcomes after anterior cervical spine surgery (ACSS) through a matching technique to control for various factors.
  • It found that the use of SSRIs and SNRIs was linked to increased rates of hematoma formation and higher emergency department visits within 30 and 90 days post-surgery.
  • The results suggest that patients on these medications may face more complications after ACSS, indicating potential risks in their perioperative management.
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IBD patients have a 4.04-fold elevated likelihood of having CRS compared to non-IBD patients. CRS patients have a 4.

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Background: Reports of reduced desire to smoke in patients treated with semaglutide, a glucagon-like peptide receptor agonist (GLP-1RA) medication for type 2 diabetes mellitus (T2DM) and obesity, have raised interest about its potential benefit for tobacco use disorders (TUDs).

Objective: To examine the association of semaglutide with TUD-related health care measures in patients with comorbid T2DM and TUD.

Design: Emulation target trial based on a nationwide population-based database of patient electronic health records.

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