2 results match your criteria: "Center for Biochemistry and Moleculare Cell Biology[Affiliation]"
Trans-Golgi network morphology and sorting is regulated by prolyl-oligopeptidase-like protein PREPL and the AP-1 complex subunit μ1A.
J Cell Sci
March 2013
Georg-August-University Göttingen, Center for Biochemistry and Moleculare Cell Biology, Biochemie II, Humboldtallee 23, 37073 Göttingen, Germany.
Article Synopsis
- The AP-1 complex is important for recycling between membranes and the cytoplasm, but its binding to membranes is influenced by the protein PREPL.
- Overexpression of PREPL reduces AP-1's ability to bind to membranes, while lower PREPL levels have the opposite effect and hinder AP-1 recycling.
- PREPL's function is crucial in regulating AP-1 membrane binding, with its deficiency linked to health issues like hypotonia and hormone secretion problems.
AP-1 membrane-cytoplasm recycling regulated by mu1A-adaptin.
Traffic
January 2008
Center for Biochemistry and Moleculare Cell Biology, Georg-August-University Göttingen, Biochemie II, Heinrich-Düker-Weg 12, D-37073 Göttingen, Germany.
The adaptor protein complex AP-1 mediates vesicular protein sorting between the trans Golgi network and endosomes. AP-1 recycles between membranes and the cytoplasm together with clathrin during transport vesicle formation and vesicle uncoating. AP-1 recycles independent of clathrin, indicating binding to unproductive membrane domains and premature termination of vesicle budding.
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