2 results match your criteria: "Center for Applied Medical Research and CIBERONC[Affiliation]"
β3 integrin expression is required for invadopodia-mediated ECM degradation in lung carcinoma cells.
PLoS One
October 2017
Department of Oncology, Center for Applied Medical Research CIMA, Pamplona, Spain.
Cancer related deaths are primarily due to tumor metastasis. To facilitate their dissemination to distant sites, cancer cells develop invadopodia, actin-rich protrusions capable of degrading the surrounding extracellular matrix (ECM). We aimed to determine whether β3 integrin participates in invadopodia formed by lung carcinoma cells, based on our previous findings of specific TGF-β induction of β3 integrin dependent metastasis in animal models of lung carcinoma.
View Article and Find Full Text PDFCharacterization of three-dimensional cancer cell migration in mixed collagen-Matrigel scaffolds using microfluidics and image analysis.
PLoS One
August 2017
Laboratory of Preclinical Models and Analytical Tools, Division of Solid Tumors and Biomarkers, Center for Applied Medical Research and CIBERONC, Pamplona, Navarra, Spain.
Article Synopsis
- Microfluidic devices help scientists study how lung cancer cells move in different environments, like how they behave in small tubes filled with special jelly-like materials.
- The study shows that the way cancer cells move changes depending on the type of jelly they are in; sometimes they move faster, and sometimes slower, depending on how thick the jelly is.
- This research can help create better ways to test treatments for cancer by using smart tools that can control the environment for the cells, making it easier to understand how to fight the disease.