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Center for Aids Prevention Studies[Affi... Publications | LitMetric

1,173 results match your criteria: "Center for Aids Prevention Studies[Affiliation]"

Background: Despite the recognised links between food insecurity and parenting, few studies have evaluated the perceived impacts of livelihood or food security interventions on parental practices, intra-household functioning, adolescent behaviour and psychosocial outcomes in HIV-affected households in sub-Saharan Africa.

Aims: The study aimed to understand the perceived effects of food security on parenting practices and how this was experienced by both adolescent girls (aged 13-19 years) and their caregivers in rural Kenya.

Method: We conducted semi-structured, individual interviews with 62 caregiver-adolescent dyads who were participants in the adolescent (NCT03741634), a sub-study of adolescent girls and caregivers with a household member participating in the agricultural and finance intervention trial (NCT01548599).

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Introduction: 50% of permanent supportive housing (PSH) residents in the U.S. smoke cigarettes, and tobacco-related mortality is their number one cause of death.

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Loneliness has reached epidemic proportions, affecting nearly one-in-two adults in the United States and is particularly potent in sexually minoritized men (SMM). Individual differences in optimism and pessimism may exert protective or maladaptive effects for the impact of discrimination on loneliness. This study investigated interrelationships between optimism/pessimism, discrimination, and loneliness within a sample of sexual minoritized men (SMM).

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Background: Leadership skills are essential for middle-level healthcare manager efficacy. Capacity-building efforts may attempt behavioural change by filling 'knowledge gaps' while neglecting a sustainable application of that knowledge. Sustainable application of that knowledge, or implementation know-how, must resonate with local cultural patterns.

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This study examined the association between self-identification as a sex worker (SW) and perceived access to pharmacologic and non-pharmacologic HIV prevention methods among MSM in France, Russia, and Türkiye amidst the COVID-19 pandemic. Globally, 17,250 MSM recruited through a geosocial networking smartphone application completed the COVID-19 disparities survey, which was administered between October and November 2020. Approximately 38% of survey respondents were identified as living in France (n = 1269), Russia (n = 3882), and Türkiye (n = 3141) at the time of survey completion.

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Current Self-reported Pain Before and After Cure of Hepatitis C Among Persons Who Actively Inject Drugs.

J Addict Med

October 2024

From the Department of Medicine, Division of General Internal Medicine, University of Washington, Harborview Adult Medicine Clinic, Seattle, WA (JIT, JRJ); Center for AIDS Prevention Studies, Department of Medicine, University of California San Francisco, San Francisco, CA (NTL-B); Department of Public Health Sciences, Clemson University, Clemson, SC (MH, LBS); Department of Medicine, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY (JA, BN); Department of Medicine, University of California, San Francisco, San Francisco, CA (PJL); Department of Pharmacy Practice and Clinical Research, University of Rhode Island, Kingston, RI (LET); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (SHM); Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD (OF-N); Department of Behavioral Medicine & Psychiatry and Department of Medicine, Infectious Diseases, West Virginia University School of Medicine, Morgantown, WV (JF); Division of Infectious Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA (AYK); Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM (KP); Department of Medicine, Clemson University, Clemson, SC (AHL); Department of Medicine, University of South Carolina School of Medicine, Greenville, SC (AHL); Department of Medicine, Prisma Health, Greenville, SC (LBS, AHL).

Article Synopsis
  • * Researchers assessed pain severity before and after treatment with sofosbuvir/velpatasvir, mainly focusing on whether achieving sustained virologic response (SVR) correlated with lower pain scores.
  • * Results showed that while overall pain severity didn't significantly differ based on SVR status, those who achieved SVR reported lower pain scores over time, especially among participants with moderate or greater pain at baseline, except at the 48-week mark for those who did not achieve SVR.
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Background: Dual use of both e-cigarettes and cigarettes is popular among young adults and may lead to greater nicotine dependence and additive adverse health effects than single-product use. However, existing cessation programs target quitting either e-cigarettes or cigarettes, highlighting a need for interventions to help young adults quit both products (ie, dual tobacco cessation).

Objective: This formative study is part of a larger project to develop a smartphone intervention for dual tobacco cessation among young adults.

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Rates of HIV acquisition remain high among adolescent girls and young women (AGYW) in sub-Saharan Africa. We explored South African, Ugandan, and Zimbabwean AGYW's experiences in a crossover trial of two HIV prevention products: Daily oral pre-exposure prophylaxis pills and a monthly dapivirine vaginal ring. A subset of participants (n = 25) across all sites completed up to three serial in-depth interviews (SIDIs).

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Background: Unhealthy alcohol use is a common public health problem in HIV care settings in Africa and it affects the HIV continuum of care. In Uganda and other low-income countries, HIV care providers are a key resource in caring for young people (15-24 years) living with HIV (YPLH) with unhealthy alcohol use. Caring for YPLH largely depends on care providers' perceptions of the problem.

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Stigma and discrimination by healthcare providers towards patients diagnosed with HIV and tuberculosis: A study from India.

Natl Med J India

September 2024

Center for AIDS Prevention Studies, University of California, UCSF DPS, Box 0886 550 16th St, 3rd floor, San Francisco 94143, California, USA.

Background High levels of human HIV and tuberculosis (TB) stigma have been reported among healthcare workers (HCWs). Methods We compared HIV and TB stigma scores reported by nursing students and ward staff from hospitals across India. Transmission worry (TW) and intent to discriminate (ID) for HIV and TB were captured using a validated stigma scale.

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Ethical Issues in Treating Substance Use Disorders: Counselor Perspectives.

J Psychoactive Drugs

August 2024

Department of Medicine, Center for AIDS Prevention Studies, University of California, San Francisco, CA, USA.

Ethical issues arise frequently in the treatment of substance use disorders (SUD). Counselors need guidance to navigate ethical dilemmas but receive limited training in resolving ethical issues. To narrow the gap between the ethical dilemmas counselors face and their training, this qualitative study assessed ethical issues that counselors encounter, how they resolve them, and desired training.

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With new pre-exposure prophylaxis (PrEP) modalities for HIV prevention becoming available, understanding how adolescent girls and young women (AGYW) navigate through PrEP options is essential, including factors underlying their choice. Through 16 focus group discussions (FGDs) and 52 in-depth interviews (IDIs) from REACH, an open-label crossover study in which AGYW were allocated 1:1 (between 06 February 2019 and 18 March 2020) to receive oral PrEP for six months and the dapivirine ring for six months, in a randomized sequence, followed by a 6-month period where either product (or neither) could be chosen, we explored decision-making process and product choice, using a mixed inductive-deductive analytical approach. Key themes included the desire to remain HIV-negative and weighing product attributes through experiential learning.

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Article Synopsis
  • - The study examined the link between methamphetamine use and awareness/interest in event-driven (ED) PrEP among HIV-negative and unknown status cisgender males and transgender individuals.
  • - Results showed that participants who recently used methamphetamine were less aware of ED PrEP but showed increased interest in it after adjusting for demographics and HIV-related behaviors.
  • - The findings suggest the need for targeted efforts to promote PrEP among methamphetamine users to effectively address the HIV epidemic, along with ongoing research to understand their specific needs.
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Vietnamese women have a higher incidence rate of cervical cancer and are less likely to have ever been screened for cervical cancer than their White counterparts in the US. This review synthesizes findings from published interventions to promote cervical cancer screening in this vulnerable population. Articles were identified through a systematic search of PsycInfo, Embase, Pubmed, Web of Science, and the Cochrane Register of Controlled Trials in October 2022.

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Article Synopsis
  • Product adherence significantly impacts the accurate evaluation of HIV-1 prevention methods like the dapivirine vaginal ring, with varying levels of adherence leading to biased efficacy estimates.* -
  • In the MTN-020/ASPIRE trial, per-protocol analyses indicated a 30.8% efficacy, while those with the highest adherence showed an efficacy of 53.6% when analyzing drug release from the ring.* -
  • Advanced statistical methods, such as principal stratification and marginal structural models, enhance our understanding of HIV-1 prevention effectiveness in clinical trials by adjusting for adherence levels.*
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Pregnant and lactating persons in sub-Saharan Africa face a heightened risk of HIV acquisition, due to biological and behavioral factors, combined with limited access to prevention and treatment services. Oral pre-exposure prophylaxis (PrEP) and the dapivirine vaginal ring are promising tools for HIV prevention, and the ring's recent approval in multiple African countries represents a significant advancement in expanding access to HIV prevention. In a nested qualitative study within the MTN-042 trial, we explored the acceptability of study products among pregnant persons in the second and early third trimesters.

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Lesbian, gay, bisexual, transgender, queer, and all sexually and gender diverse (LGBTQ+) youth with HIV face multiple barriers to progression along the HIV care continuum. We searched PubMed, PsycInfo, clinicaltrials.gov, and the Adolescent Medicine Trials Network for HIV/AIDS Interventions for interventions focused on improving linkage to care, retention in care, adherence to antiretroviral therapy, or viral suppression (VS) among LGBTQ+ youth with HIV in the United States.

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Purpose: We examined the correlates of disability among people with non-communicable diseases (NCDs) and comorbid common mental disorders (CMDs) from rural India.

Methods: The sample comprised 2,486 participants enrolled in a cluster randomized trial (cRCT), Healthier OPtions through Empowerment (HOPE). Participants were 30 years or older, with a diagnosis of major depressive disorder, dysthymia, generalized anxiety disorder, and/or panic disorder on the MINI-International Neuropsychiatric Interview, with hypertension, diabetes, dsylipidemia and/ or ischemic heart disease.

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Background: Much of the latent tuberculosis (TB) reservoir is established in childhood and adolescence. Yet, age-specific data on prevalence and predictors of infection in this population are sparse and needed to guide prevention and case finding.

Methods: From December 2021 to June 2023, we measured TB infection in children 1-17 years in 25 villages in rural Southwestern Uganda.

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Article Synopsis
  • - Chronic pain is prevalent in individuals with HIV, necessitating effective treatment options tailored to their needs; this study assesses a behavioral intervention called Skills to Manage Pain (STOMP) against enhanced usual care (EUC).
  • - The randomized trial involved 278 adults with HIV suffering from significant chronic pain, conducted across two major medical centers between August 2019 and September 2022.
  • - Results indicated that participants in the STOMP group experienced a significant reduction in pain severity compared to those receiving EUC, with a mean attendance of nearly three one-on-one sessions and two group sessions among participants.
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"I Heard of PrEP-I Didn't Think I Needed it." Understanding the Formation of HIV Risk Perception Among People Who Inject Drugs.

Cult Med Psychiatry

December 2024

Department of Family and Community Medicine, University of California, San Francisco, 490 Illinois Street, San Francisco, CA, 94158, USA.

Uptake of pre-exposure prophylaxis medication (PrEP) to prevent HIV among people who inject drugs (PWID) remains extremely low in the United States. West Virginia's rising HIV incidence and highest drug overdose rate in the nation makes it an important locus for opioid use and HIV risk interaction. In this pilot study we pioneered the use of Cultural Theory among PWID to understand HIV-related risk perception arising from four contrasting modes of social organization.

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Parental Gender Affirmation Model: A culturally informed framework.

SSM Ment Health

June 2024

Department of Medicine, Center for AIDS Prevention Studies, University of California, San Francisco, 550 16th Street, San Francisco, CA, 94158, USA.

Benefits of parental gender-affirming behaviors on the mental health and well-being of the broader gender-expansive youth population have been extensively documented. However, the nature and impact of these behaviors have not been explored by centering Black and Latine transgender/non-binary youth (BLTY). This article offers a new framework called the "Parental Gender Affirmation Model.

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