5 results match your criteria: "Center for Agricultural Sciences and Biodiversity[Affiliation]"
Dioclea violacea lectin has potent in vitro leishmanicidal activity against Leishmania infantum via carbohydrate recognition domain.
Int J Biol Macromol
September 2024
Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, CE, Brazil; Center for Agricultural Sciences and Biodiversity, Federal University of Cariri, Crato, CE, Brazil. Electronic address:
Article Synopsis
- Existing leishmaniasis treatments have limitations and side effects, prompting the exploration of new alternatives like the lectin DVL from Dioclea violacea seeds.
- DVL showed significant leishmanicidal effects against Leishmania infantum in vitro, inducing reactive oxygen species and damaging the parasite's membrane, with an effective concentration of 49.37 μg/mL.
- DVL enhanced the effectiveness of traditional drugs like amphotericin B and glucantime, reduced macrophage infection rates, and exhibited no toxicity in healthy cells, indicating its potential as a treatment for visceral leishmaniasis.
Vasorelaxant effect of phenylpropanoids: Methyl eugenol and eugenol in human umbilical cord vein.
Biomed Pharmacother
September 2024
Postgraduate Program in Physiological Sciences of the Universidade Estadual do Ceará - PPGCF/UECE, Fortaleza, Ceará, Brazil; Postgraduate Program in Biological Chemistry of the Universidade Regional do Cariri - PPQB/URCA, Crato, Ceará, Brazil.
Methyl-eugenol (ME) and eugenol (EUG) are phenylpropanoids with vasodilatory effects. While EUG's vasorelaxant effect in human umbilical artery (HUA) is known, their action in veins is unclear. This study aimed to evaluate ME and EUG in human umbilical vein (HUV).
View Article and Find Full Text PDFIn vitro antiproliferative effects of Vatairea macrocarpa (Benth.) Ducke lectin on human tumor cell lines and in vivo evaluation of its toxicity in Drosophila melanogaster.
Food Chem Toxicol
August 2024
Center for Agricultural Sciences and Biodiversity, Universidade Federal do Cariri, Crato, CE, Brazil. Electronic address:
Tumor cells may develop alterations in glycosylation patterns during the initial phase of carcinogenesis. These alterations may be important therapeutic targets for lectins with antitumor action. This work aimed to evaluate the in vitro cytotoxicity of VML on tumor and non-tumor cells (concentration of 25 μg/mL and then microdiluted) and evaluate its in vivo toxicity at different concentrations (1.
View Article and Find Full Text PDFMetabolomic profile of seminal plasma from Guzerá bulls (Bos indicus) with contrasting sperm freezability phenotypes.
Reprod Domest Anim
October 2023
Department of Animal Science, Federal University of Ceará, Fortaleza, Brazil.
The present study evaluated the seminal plasma metabolome of Bos indicus Guzerá bulls with good (n = 4) and poor (n = 5) sperm freezability. Animals were raised in natural pasture of a 'Caatinga' ecosystem, in the semi-arid region of Brazil. Seminal plasma samples were subjected to gas chromatography coupled to mass spectrometry and data, analysed using bioinformatics tools (Cytoscape with the MetScape plug-in).
View Article and Find Full Text PDFDVL, lectin from Dioclea violacea seeds, has multiples mechanisms of action against Candida spp via carbohydrate recognition domain.
Chem Biol Interact
September 2023
Center for Agricultural Sciences and Biodiversity, Federal University of Cariri, Crato, 63130-025, Brazil. Electronic address:
Lectins are proteins of non-immunological origin with the ability to bind to carbohydrates reversibly. They emerge as an alternative to conventional antifungals, given the ability to interact with carbohydrates in the fungal cell wall inhibiting fungal growth. The lectin from D.
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