Hepatic ischemia/reperfusion injury (IRI) is a serious issue during liver surgery and transplantation, especially in patients with nonalcoholic steatohepatitis (NASH).
The study found that histidine-rich glycoprotein (HRG) plays a protective role against liver damage caused by IRI, as its levels decrease in fatty livers, which contributes to increased injury.
HRG's presence helps reduce neutrophil infiltration and associated damage, suggesting it could be a potential therapeutic target for minimizing liver damage in NASH patients.