Dementia Care Practice.

Alzheimer's disease and related dementias (ADRD) and its associated care pose unique challenges, particularly within minority groups such as Muslim women. This population may face higher rates of ADRD alongside barriers to accessing culturally sensitive care. This abstract emphasizes the crucial role of understanding and integrating Islamic cultural and religious practices into ADRD care.

Cognitive Distortions and Decision-Making in Women Victims of Intimate Partner Violence: A Scoping Review.

Exposing women to intimate partner violence (IPV) poses a risk to their physical and mental health, necessitating that they leave the relationship. However, women face various obstacles in doing so, such as cognitive distortions that affect their interpretation of the reality of violence, trapping them and significantly influencing their decision to leave. This scoping review explores, synthesizes, and analyzes the available evidence on the relationship between cognitive distortions and decision-making among women involved in IPV.

Implementation of O-RADS Ultrasound Reporting System: A Quality Improvement Initiative.

To determine the feasibility of implementing Ovarian-Adnexal Reporting & Data System (O-RADS) ultrasound (US) for reporting of adnexal masses at our institution, with a specific goal of increasing the use of O-RADS from a baseline of <5% to at least 75% over a 16-month period. A prospective interrupted time series quality improvement study was undertaken over a 16-month period. Plan, do, study, act cycles included: (1) Engagement of interested parties, (2) Targeted educational sessions, (3) Development of reporting templates, (4) Weekly audit-feedback.

Accurate predictions on small data with a tabular foundation model.

Tabular data, spreadsheets organized in rows and columns, are ubiquitous across scientific fields, from biomedicine to particle physics to economics and climate science. The fundamental prediction task of filling in missing values of a label column based on the rest of the columns is essential for various applications as diverse as biomedical risk models, drug discovery and materials science. Although deep learning has revolutionized learning from raw data and led to numerous high-profile success stories, gradient-boosted decision trees have dominated tabular data for the past 20 years.

Association between chronic diseases and severe periodontal disease progression: A retrospective cohort study in a city of Japan.

Background: Chronic periodontal disease primarily causes tooth loss and oral frailty and is linked to chronic conditions such as diabetes mellitus. However, its progression and broader studies on chronic diseases have not been well explored. This study aimed to investigate this association using claims data.

Chronic viral mimicry induction following p53 loss promotes immune evasion.

Epigenetic therapies facilitate transcription of immunogenic repetitive elements that cull cancer cells through 'viral mimicry' responses. Paradoxically, cancer-initiating events also facilitate transcription of repetitive elements. Contributions of repetitive element transcription towards cancer initiation, and the mechanisms by which cancer cells evade lethal viral mimicry responses during tumor initiation remain poorly understood.

The role of resistin and adiponectin ratios with uric acid in assessing metabolic syndrome in type 2 diabetes.

Metabolic syndrome (MetS) is a growing global healthcare burden. Patients with type 2 diabetes mellitus (T2DM) are more likely to acquire MetS than the general population. Recent research suggests that the interaction of adipose tissue products, such as adiponectin resistin and uric acid, is essential in MetS onset.

Analyzing temporal imaging patterns in acute ischemic stroke via DICOM-timestamps.

Acute stroke management is time-sensitive, making time data crucial for both research and quality management. However, these time data are often not reliably captured in routine clinical practice. In this proof-of-concept study we analysed image-based time data automatically captured in the DICOM format.

Targeting Nerve Fiber Outgrowth Inhibition After Experimental Spinal Cord Injury: A Systematic Review and Meta-analysis of Chondroitinase ABC.

Background: Spinal cord injury (SCI) can impair motor, sensory, and autonomic function. The formation of the glial scar comprises protective as well as inhibitory neurite outgrowth properties operated by the deposition of chondroitin sulfate proteoglycans (CSPG). Chondroitinase ABC (ChABC) can degrade CSPG and foster neuroaxonal plasticity as a therapeutic approach to restore locomotor function after SCI.

Impact of Postoperative Norepinephrine Administration on Free Flap Flow.

The perioperative interplay between blood pressure, vasopressors, and macrocirculation is well established. However, in the context of free flap surgery, the potential impact of these factors on microvascular flow remains elusive. The aim was to evaluate the impact of norepinephrine administration on the microcirculation of free flaps.

Fully Automated Assessment of Cardiac Chamber Volumes and Myocardial Mass on Non-Contrast Chest CT with a Deep Learning Model: Validation Against Cardiac MR.

: To validate the automated quantification of cardiac chamber volumes and myocardial mass on non-contrast chest CT using cardiac MR (CMR) as a reference. : We retrospectively included 53 consecutive patients who received non-contrast chest CT and CMR within three weeks. A deep learning model created cardiac segmentations on axial soft-tissue reconstructions from CT, covering all four cardiac chambers and the left ventricular myocardium.

RNA N4-acetylcytidine modification and its role in health and diseases.

N4-acetylcytidine (ac4C) modification is a crucial RNA modification widely present in eukaryotic RNA. Previous studies have demonstrated that ac4C plays a pivotal role in viral infections. Despite numerous studies highlighting the strong correlation between ac4C modification and cancer progression, its detailed roles and molecular mechanisms in normal physiological processes and cancer progression remain incompletely understood.

Postoperative dizziness after cochlear implant surgery: can it be caused by air?

Objectives: Multiple studies have described the onset and variable incidence of postoperative acute vertigo following cochlear implant (CI) surgery. However, postoperative imaging has not yet been specifically evaluated with special focus on vertigo. The aim of this study is to assess the incidence and causes of new-onset, acute postoperative vertigo following CI surgery using cone beam computed tomography (CBCT).

Accuracy of digital and conventional implant impressions in edentulous jaws: a clinical comparative study.

Objectives: This clinical study aimed to evaluate the accuracy of digital and conventional implant impressions in a fully edentulous maxilla and mandible.

Methods: A 53-year-old edentulous patient with four maxillary and two mandibular implants was selected. Ten intraoral scans (IOS) and a conventional impression per jaw were taken.

Effectiveness and safety of iGlarLixi in people with type 2 diabetes not at target on basal insulin and oral antidiabetic therapy in a prospective observational trial.

Aims: This study assessed efficacy and safety of the fixed ratio combination iGlarLixi 100/33 (insulin glargine 100 U/mL plus lixisenatide 33 μg/mL) in people with type 2 diabetes (PwT2D) in daily clinical practice.

Materials And Methods: This non-interventional, multicentre, prospective, single-arm 24-week study documented PwT2D with an HbA1c of 7.5%-10.

High expression of H2AX/γ-H2AX is associated with distinct biological pathway alterations and shorter survival in oropharyngeal squamous cell carcinoma.

Background: The histone gene H2AX and its phosphorylated protein γ-H2AX play a crucial role in the DNA damage response. This study investigates the expression of H2AX mRNA and its phosphorylated γ-H2AX protein in oropharyngeal squamous cell carcinoma (OPSCC), its association with distinct biological pathway alterations and its potential as a biomarker.

Materials And Methods: Expression of H2AX mRNA in 76 OPSCC from The Cancer Genome Atlas (TCGA) cohort was analyzed.

Perceptions and Experiences of Surgical Nurses in Using the WHO Checklist in a Perioperative Setting: a Mixed-method Study.

Background: As a surgical nurse in a healthcare team, it is helpful to position the patient, depending on the nature of the procedure, and to prepare independently both the instrumentation and the site of surgery with drapes prior to the surgical procedure.

Objective: To examine the experience of surgical nurses in their work with the WHO surgical checklist in Sweden.

Methods: Data were collected from one hundred and ninety-six healthcare professionals, including thirty-nine surgical nurses, using a self-administered questionnaire.

The association of dementia risk symptoms and functional activity in adults with Down syndrome.

Introduction: Adults with Down syndrome (DS) have an increased risk of Alzheimer's disease (AD) dementia, often showing neuropathological indicators by age 40. Physical function and activities of daily living (ADLs) are understudied areas of function that may inform dementia risk. We investigated associations among age, physical function (gait/balance, grip strength, and lower extremity strength), ADLs, and dementia risk symptoms in adults with DS.

Impacts of informant replacement in two industry-sponsored Alzheimer's disease clinical trials.

Introduction: In Alzheimer's disease (AD) clinical trials, participants must enroll with a study partner informant who completes validated study instruments. We hypothesized that mid-trial informant replacement impacts study data in industry-sponsored trials.

Methods: We conducted a retrospective analysis of two industry-sponsored AD clinical trials testing semagacestat in mild-to-moderate AD dementia.

Assessment of disease impact through health-related quality of life measurement in primary progressive aphasia.

Introduction: Measurements of health-related quality of life (HRQoL) are important for capturing disease impact beyond physical health and relative to other diseases but have rarely been assessed in primary progressive aphasia (PPA).

Methods: HRQoL was characterized overall, by sex and subtype in PPA ( = 118) using the Health Utilities Index-2/3 (HUI2/3). Multiple linear regression assessed associations between HRQoL and language severity.

Prostatic E. coli infection drives CCR2-dependent recruitment of fibrocytes and collagen production.

Prostate fibrosis contributes to lower urinary tract dysfunction (LUTD). To develop targeted treatments for prostate fibrosis, it is necessary to identify cell types and molecular pathways required for collagen production. We used a genetic approach to label and track potential collagen-producing cell lineages in mouse prostate through a round of Escherichia coli (E.