171 results match your criteria: "Center II[Affiliation]"
Front Neurosci
November 2024
Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
Non-invasive vagus nerve stimulation (VNS) represents a transformative approach for managing a broad spectrum of inflammatory and autoimmune conditions, including rheumatoid arthritis and inflammatory bowel disease. This comprehensive review delineates the mechanisms underlying VNS, emphasizing the cholinergic anti-inflammatory pathway, and explores interactions within the neuro-immune and vagus-gut axes based on both clinical outcomes and pre-clinical models. Clinical applications have confirmed the efficacy of VNS in managing specific autoimmune diseases, such as rheumatoid arthritis, and chronic inflammatory conditions like inflammatory bowel disease, showcasing the variability in stimulation parameters and patient responses.
View Article and Find Full Text PDFJ Pathol Clin Res
November 2024
Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.
In recent years, it has become clear that artificial intelligence (AI) models can achieve high accuracy in specific pathology-related tasks. An example is our deep-learning model, designed to automatically detect serous tubal intraepithelial carcinoma (STIC), the precursor lesion to high-grade serous ovarian carcinoma, found in the fallopian tube. However, the standalone performance of a model is insufficient to determine its value in the diagnostic setting.
View Article and Find Full Text PDFFront Public Health
October 2024
Department of Emergency Center II, People's Hospital of Xinjiang Uygur Autonomous Region, Ürümqi, Xinjiang, China.
Purpose: There is limited understanding of the link between exposure to heavy metals and ischemic stroke (IS). This research aimed to develop efficient and interpretable machine learning (ML) models to associate the relationship between exposure to heavy metals and IS.
Methods: The data of this research were obtained from the National Health and Nutrition Examination Survey (US NHANES, 2003-2018) database.
Epidemiologia (Basel)
August 2024
Public Health Center, 12003 Castelló de la Plana, Spain.
Determining the number of cases of an epidemic is the first function of epidemiological surveillance. An important underreporting of cases was observed in many locations during the first wave of the COVID-19 pandemic. To estimate this underreporting in the COVID-19 outbreak of Borriana (Valencia Community, Spain) in March 2020, a cross-sectional study was performed in June 2020 querying the public health register.
View Article and Find Full Text PDFFront Immunol
December 2023
INEM, CNRS, UMR7355, Orléans, France and Experimental and Molecular Immunology and Neurogenetics, University of Orléans, Orleans, France.
J Neurol
February 2024
I Division of Neurology, Department of Advanced Medical and Surgical Sciences, University of Campania Luigi Vanvitelli, Piazza Miraglia, 2, 80138, Naples, Italy.
Introduction: During the COVID-19 pandemic, ocrelizumab (OCR) infusions for MS patients were often re-scheduled because of MS center's disruption and concerns regarding immunosuppression. The aim of the present study was to assess changes in OCR schedule during the first wave of pandemic in Italy and to evaluate the effect of delayed infusion on clinical/radiological endpoints.
Methods: Data were extracted from the Italian MS Register database.
Span J Psychiatry Ment Health
November 2023
Biomedical Research Network in Mental Health (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Department of Psychiatry, Institute for Health Research (imas12), 12 de Octubre University Hospital, Madrid, Spain.
Introduction: Globally, depression is the most common psychiatric disorder and is frequently associated with somatic symptom disorders, including pain as a physical symptom. There is a current need to improve the detection and management of the individuals in which depression and pain coexist. Hence, the aim of this document is to provide recommendations in the diagnosis and management of patients with major depressive disorder (MDD) who have pain as a physical symptom (PPS), in order to reduce the variability of clinical practice.
View Article and Find Full Text PDFComput Struct Biotechnol J
July 2023
National Centre for Biological Sciences (TIFR), GKVK campus, Bangalore 560065, India.
Toll-like receptors (TLRs) are pattern recognition receptors present on the surface of cells playing a crucial role in innate immunity. One of the TLRs, TLR4, recognizes LPS (Lipopolysaccharide) as its ligand leading to the release of anti-inflammatory mediators as well as pro-inflammatory cytokines through signal transduction and domain recruitment. TLR4 homodimerizes at its intracellular TIR (Toll/interleukin-1 receptor) domain that helps in the recruitment of the TRAM/TICAM2 (TIR domain-containing adaptor molecule 2) molecule.
View Article and Find Full Text PDFPublic Health Nutr
October 2023
National Military Family Association, 2800 Eisenhower Avenue, Suite 250, Alexandria, VA22314, USA.
Objective: The present study examined military families' use of food distribution resources and military (e.g. rank) and non-military (e.
View Article and Find Full Text PDFPathogens
June 2023
Department of Veterinary Hygiene and Public Health, São Paulo State University, Botucatu 05508-220, Brazil.
The performance of a commercial immunofluorescence assay (IFA commercial), an immunofluorescence assay (IFA ) and an indirect enzyme-linked immunosorbent assay (ELISA) were evaluated in the detection of antibodies anti- in the serum of Q fever patients and persons without the disease. For the study, seropositive and seronegative samples for Q fever ( = 200) from a serum bank of the Instituto Adolfo Lutz in Brazil were used. Commercial IFA was considered in this study as the gold standard for diagnosing Q fever.
View Article and Find Full Text PDFMicrobiol Mol Biol Rev
September 2023
Department of Pathology and Microbiology, University of Nebraska Medical Center, Durham Research Center II, Omaha, Nebraska, USA.
Transfusion
May 2023
Advanced Cell Therapy Core, Sidra Medicine, Doha, Qatar.
Chem Biodivers
April 2023
Chemical Research Department, APL Research Center-II, Aurobindo Pharma Ltd., Sangareddy, Telangana-502329, India.
Our current work is aimed at synthesizing novel substituted 1,2,4-triazolyl-fluoroquinolone analogs and study of their biological activity to find active promising molecules. The structural elucidation of the products was demonstrated by a variety of spectroscopic methods such as IR, H-NMR, C-NMR, mass and elemental analysis. The newly synthesized 1,2,4-triazole derivatives were tested in vitro for their ability to inhibit the growth of seven different microbes including S.
View Article and Find Full Text PDFIndian J Med Microbiol
March 2023
Community Medicine Department, GMERS Medical College, Sola, Ahmedabad, Gujarat 380060, India.
Purpose: To understand the benefits of COVID-19 vaccination (Covishield, Covaxin) on clinical features and outcome of COVID-19 during the third wave in India.
Materials And Methods: The primary study aim was to describe the clinical profile and outcome of COVID-19 regarding their vaccination and to identify risk factors for disease progression in vaccinated patients. This was a prospective observational multicentric study of COVID-19 attended by Infectious Disease physicians during January 15, 2022 to February 15, 2022.
J Sch Health
May 2023
Department of Social and Behavioral Sciences, West Virginia University School of Public Health, PO Box 9190, 3314 HSC South, 64 Medical Center Drive, Morgantown, WV, 26505.
Background: Young people who experience higher levels of social support from their schools and families have been shown to be less likely to develop symptoms of negative mental health outcomes such as depression and anxiety. This raises questions concerning how young people's stress and psychological changes due to the COVID-19 pandemic as well as social support during this time have affected their overall mental health. The aim of this study was to assess the association between sources of parental- and school-level social support and youth perceptions of COVID-19-related emotional impact on mental health among early adolescent girls and boys in Appalachia.
View Article and Find Full Text PDFCell
January 2023
Paul F. Glenn Center for Biology of Aging Research, Department of Genetics, Blavatnik Institute, Harvard Medical School (HMS), Boston, MA, USA. Electronic address:
All living things experience an increase in entropy, manifested as a loss of genetic and epigenetic information. In yeast, epigenetic information is lost over time due to the relocalization of chromatin-modifying proteins to DNA breaks, causing cells to lose their identity, a hallmark of yeast aging. Using a system called "ICE" (inducible changes to the epigenome), we find that the act of faithful DNA repair advances aging at physiological, cognitive, and molecular levels, including erosion of the epigenetic landscape, cellular exdifferentiation, senescence, and advancement of the DNA methylation clock, which can be reversed by OSK-mediated rejuvenation.
View Article and Find Full Text PDFSmall Bus Econ (Dordr)
August 2022
Institute for International Science and Technology Policy & Department of Economics, George Washington University, 1957 E Street NW Suite 403, Washington DC, 20052 USA.
This paper examines the effect of translational research on knowledge production and biomedical entrepreneurship across U.S. regions.
View Article and Find Full Text PDFHealth Promot Int
December 2022
Nursing Department, Federal University of Minas Gerais, Avenida Professor Alfredo Balena, 190. Santa Efigênia, CEP: 30130100, Belo Horizonte, MG, Brazil.
The purpose of this study was to estimate the association between environmental variables and leisure-time physical activity levels in an adult population of a medium-sized city in Brazil. This is a cross-sectional study with a sample of 965 adults (20-59 years). Individual, socioeconomic, demographic and behavioral data were obtained through a population-based survey.
View Article and Find Full Text PDFBiomed Chromatogr
January 2023
Department of Chemistry, GITAM School of Science, Hyderabad, Telangana, India.
Potential genotoxic impurities (PGI) and N-nitrosamine impurities in active pharmaceutical ingredients (APIs) and their determination at low levels are substantial challenges for cholesterol-lowering agents in recent years. Herein we developed a robust, reliable, rapid, accurate and validated technique of gas chromatography equipped with a mass spectrometer (GC-MS) for quantifying subtle levels of 1,3-dichloro-2-propanol (PGI-I) and 2,3-dichloro-1-propanol (PGI-II) in colesevelam hydrochloride drug substance (bile acid sequestrant). The separation of colesevelam hydrochloride, PGI-I and PGI-II was executed with chromatographic technique using a capillary column, DB-624 measuring with 30 m × 0.
View Article and Find Full Text PDFGlob Health Res Policy
September 2022
Sekolah Tinggi Ilmu Kesehatan Tamalatea Makassar, Makassar, Indonesia.
Background: Child marriage remains an important social issue in Indonesia. Child marriages were reported from 14.67% in 2008 to 10.
View Article and Find Full Text PDFFront Mol Neurosci
September 2022
Cerebrovascular Disease Center of Gansu Provincial People's Hospital, Lan Zhou, China.
Respirable fine particulate matter (PM) has been one of the most widely publicized indicators of pollution in recent years. Epidemiological studies have established a strong association between PM, lung disease, and cardiovascular disease. Recent studies have shown that PM is also strongly associated with brain damage, mainly cerebrovascular damage (stroke) and neurological damage to the brain (changes in cognitive function, dementia, psychiatric disorders, etc.
View Article and Find Full Text PDFNutrients
September 2022
CP Kelco, 123 rue Jules Guesde, 92300 Levallois-Perret, France.
Pectin is a dietary fiber, and its health effects have been described extensively. Although there are limited clinical studies, there is a growing body of evidence from in vitro studies investigating the effect of pectin on human gut microbiota. This comprehensive review summarizes the findings of gut microbiota modulation in vitro as assessed by 16S rRNA gene-based technologies and elucidates the potential structure-activity relationships.
View Article and Find Full Text PDFActa Trop
November 2022
Parasitology and Mycology Center, Adolfo Lutz Institute (IAL), São Paulo, São Paulo, Brazil. Electronic address:
Previous studies demonstrated that insecticide collars are highly effective in reducing canine visceral leishmaniasis (CVL); however, it is unclear if the efficacy differs by socioeconomic conditions across diverse communities. This study aimed fourfold: (i) to evaluate the protection of 4% impregnated deltamethrin collared (DMC) dogs in different areas of an endemic city for visceral leishmaniasis (VL); (ii) to analyze socioeconomic variables with the seroconversion rates; (iii) to analyze the indirect effect of DMC on untreated dogs in areas of intervention; and, (iv) to evaluate the potential transmission to other dogs in the same household when one positive dog is present. The study employed the municipality of Bauru, São Paulo, Brazil, as the area of interest and used Geographic Information System tools to fit binary logistic regression models.
View Article and Find Full Text PDFIntroduction: The safety and efficacy of tirofiban in intravenous thrombolysis (IVT) bridging to mechanical thrombectomy in patients with acute ischemic stroke (AIS) is unknown. The purpose of this meta-analysis was to evaluate the safety and efficacy of tirofiban in IVT bridging to mechanical thrombectomy in acute ischemic stroke.
Methods: We systematically searched PubMed, EMBASE, Web of Science, and The Cochrane Library, CNKI, and Wan Fang databases for randomized controlled trials and observational studies (case-control studies and cohort studies) comparing the tirofiban and non-tirofiban groups in AIS intravenous thrombolysis bridging to mechanical thrombectomy (Published by November 20, 2021).
PLoS Negl Trop Dis
May 2022
Department of Veterinary Hygiene and Public Health, Paulista State University "Júlio de Mesquita Filho", Botucatu, São Paulo, Brazil.
Q fever and brucellosis are zoonoses that cause fever and other systemic clinical signs in humans; their occurrences are neglected and the differential diagnosis for some diseases is disregarded. This study aimed to investigate the seropositivity for Coxiella burnetii and Brucella spp. antibodies in patients suspected of dengue from 38 municipalities in the state of São Paulo, Brazil.
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