114 results match your criteria: "Cedars-Sinai Hospital[Affiliation]"
Ann Glob Health
February 2021
Northwestern University Feinberg School of Medicine, Department of Surgery, Chicago, USA.
Background: Trauma is a major global health problem and majority of the deaths occur in low- and middle-income countries (LMICs), at even higher rates in the rural areas. The three-delay model assesses three different delays in accessing healthcare and can be applied to improve surgical and trauma healthcare delivery. Prior to implementing change, the capacities of the rural India healthcare system need to be identified.
View Article and Find Full Text PDFClin Diabetes
December 2020
Cedars Sinai Medical Group and Providence Cedars Sinai Hospital, Encino, CA.
This article focuses on the challenges to and rewards of using technology in diabetes care. The authors provide everyday, practical information regarding the integration of technology, including insulin pumps, continuous glucose monitoring devices, and other diabetes consumer technologies, into busy primary care practices. Cases are presented to highlight these tips.
View Article and Find Full Text PDFPurpose: There remains a lack of clarity regarding the influence of sequencing of androgen deprivation therapy (ADT) and radiotherapy (RT) on outcomes in prostate cancer (PCa). Herein, we evaluate the optimal sequencing of ADT with prostate-directed RT in localized PCa.
Methods: MEDLINE (1966-2018), Embase (1982-2018), ClinicalTrials.
Background/objective: Stress-related mucosal bleeding (SRMB) occurs in approximately 2-4% of critically ill patients. Patients with aneurysmal subarachnoid hemorrhage (aSAH) have a (diffuse) space-occupying lesion, are critically ill, often require mechanical ventilation, and frequently receive anticoagulation or antiplatelet therapy after aneurysm embolization, all of which may be risk factors for SRMB. However, no studies have evaluated SRMB in patients with aSAH.
View Article and Find Full Text PDFOtol Neurotol
February 2021
Division of Neurotology, House Ear Institute.
Objective: Patients with vestibular schwannoma who harbor a genetic predisposition for venous thromboembolism require special consideration when determining optimal therapeutic management. The primary objective of the current study was to provide recommendations on treatment of hypercoagulable patients with vestibular schwannoma through a case series and review of the literature.
Patients: Two patients who underwent resection of vestibular schwannomas.
World Neurosurg
January 2021
Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. Electronic address:
In conjunction with neurofibromas, schwannomas are the second most commonly occurring intradural extramedullary tumor. They are a benign encapsulated nerve sheath tumor that are typically slow growing. They occur equally as frequently in the cervical and lumbar spine.
View Article and Find Full Text PDFJAMA Netw Open
August 2020
Department of Emergency Medicine, Massachusetts General Hospital, Boston.
Importance: The risk of death from acute pulmonary embolism can range as high as 15%, depending on patient factors at initial presentation. Acute treatment decisions are largely based on an estimate of this mortality risk.
Objective: To assess the performance of risk assessment scores in a modern, US cohort of patients with acute pulmonary embolism.
Updates Surg
April 2021
Division of Trauma, Burns and Surgical Critical Care, Department of Surgery, University of California, Irvine, 333 The City Blvd West, Suite 1600, Orange, CA, 92868-3298, USA.
Trauma pancreaticoduodenectomy (TP) remains a challenging operation with morbidity and mortality rates as high as 80% and 50%. Many trauma surgeons consider it surgical dogma to avoid performing a TP during the index operation for patients with severe pancreatic or duodenal injuries. However, there is no modern analysis evaluating this belief.
View Article and Find Full Text PDFLasers Med Sci
March 2021
Oral Diagnosis Departament, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.
Obstet Gynecol
July 2020
Department of Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, and Kaiser Permanente, Los Angeles Medical Center, Los Angeles, California; Columbia University, New York, New York; Albert Einstein College of Medicine, Bronx, New York; MedStar Washington Hospital Center/MedStar Georgetown, Washington, DC; Emory University, Atlanta, Georgia; Johns Hopkins School of Medicine, Baltimore, Maryland; Vanderbilt University Medical Center, Nashville, Tennessee; Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts; University of Wisconsin, Madison, Wisconsin; University of Washington and VA Puget Sound Health Care System, Seattle, Washington; Northwestern University, Chicago Illinois; University of Arizona College of Medicine, Phoenix, Arizona; Cedars-Sinai Hospital, Los Angeles, California; University of Toronto, Toronto, Ontario, Canada; Mayo Clinic, Jacksonville Florida; and Certification Management Services, Heber City, Utah.
Objective: To establish validity evidence for the Essentials in Minimally Invasive Gynecology laparoscopic and hysteroscopic simulation systems.
Methods: A prospective cohort study was IRB approved and conducted at 15 sites in the United States and Canada. The four participant cohorts based on training status were: 1) novice (postgraduate year [PGY]-1) residents, 2) mid-level (PGY-3) residents, 3) proficient (American Board of Obstetrics and Gynecology [ABOG]-certified specialists without subspecialty training); and 4) expert (ABOG-certified obstetrician-gynecologists who had completed a 2-year fellowship in minimally invasive gynecologic surgery).
Cancer Epidemiol Biomarkers Prev
July 2020
Zoe Global Limited, London, United Kingdom.
The rapid pace of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; COVID-19) pandemic presents challenges to the real-time collection of population-scale data to inform near-term public health needs as well as future investigations. We established the COronavirus Pandemic Epidemiology (COPE) consortium to address this unprecedented crisis on behalf of the epidemiology research community. As a central component of this initiative, we have developed a COVID Symptom Study (previously known as the COVID Symptom Tracker) mobile application as a common data collection tool for epidemiologic cohort studies with active study participants.
View Article and Find Full Text PDFActa Neurochir (Wien)
June 2020
Department of Neurological Surgery, University of California, San Francisco, CA, USA.
Background: Little information exists regarding longer-term outcomes with minimally invasive spine surgery (MISS), particularly regarding long-segment and deformity procedures. We aimed to evaluate intermediate-term outcomes of MISS for adult spinal deformity (ASD).
Methods: This retrospective review of a prospectively collected multicenter database examined outcomes at 4 or more years following circumferential MIS (cMIS) or hybrid (HYB) surgery for ASD.
Sci Rep
March 2020
Interventional and Diagnostic Neuroradiology Department, Toulouse University Hospital, Toulouse, France.
An increasing number of centers not necessarily equipped with biplane (BP) angiosuites are performing mechanical thrombectomy (MT) in acute ischemic stroke patients. We assessed whether MT performed on single-plane (SP) is equivalent in terms of safety, effectiveness, radiation and contrast agent exposure. Consecutive patients treated by MT in four high volume centers between January 2014 and May 2017 were included.
View Article and Find Full Text PDFJACC Cardiovasc Interv
March 2020
Quebec Heart & Lung Institute, Laval University, Quebec City, Quebec, Canada. Electronic address:
Objectives: This study sought to determine the incidence, clinical impact, and changes over time of mitral regurgitation (MR) in patients with low-flow, low-gradient aortic stenosis (LFLG-AS) undergoing transcatheter aortic valve replacement (TAVR).
Background: Few data exist on the clinical impact and changes in severity over time of MR in patients with LFLG-AS undergoing TAVR.
Methods: A total of 308 TAVR candidates with LFLG-AS were included.
World Neurosurg
May 2020
Department of Neurological Surgery, Scripps Clinic Torrey Pines, La Jolla, USA.
Background: It is well known that clinical improvements following surgical intervention are variable. While all surgeons strive to maximize reliability and degree of improvement, certain patients will fail to achieve meaningful gains. We aim to analyze patients who failed to reach minimal clinically important difference (MCID) in an effort to improve outcomes for minimally invasive deformity surgery.
View Article and Find Full Text PDFJ Neurosurg Spine
December 2019
13Department of Neurological Surgery, University of California, San Francisco, California.
Objective: The past decade has seen major advances in techniques for treating more complex spinal disorders using minimally invasive surgery (MIS). While appealing from the standpoint of patient perioperative outcomes, a major impediment to adoption has been the significant learning curve in utilizing MIS techniques.
Methods: Data were retrospectively analyzed from a multicenter series of adult spinal deformity surgeries treated at eight tertiary spine care centers in the period from 2008 to 2015.
JACC Cardiovasc Interv
July 2019
Valve Science Center, Minneapolis Heart Institute Foundation, Abbott Northwestern Hospital, Minneapolis, Minnesota.
Objectives: The aim of this study was to examine the relation between institutional experience and procedural results of transcatheter mitral valve repair.
Background: Transcatheter mitral valve repair for the treatment of mitral regurgitation (MR) is a complex procedure requiring navigation of the left atrium, left ventricle, and mitral valve apparatus using echocardiographic guidance.
Methods: MitraClip procedures from the Society of Thoracic Surgeons/American College of Cardiology TVT (Transcatheter Valve Therapy) Registry were stratified into tertiles on the basis of site-specific case sequence (1 to 18, 19 to 51, and 52 to 482).
Pain Med
December 2019
The Pain Center, Cedars Sinai Hospital, Los Angeles, California, USA.
World Neurosurg
July 2019
Department of Neurosurgery, University of California San Francisco, San Francisco, California, USA.
Objective: To compare circumferential minimally invasive (cMIS) versus open surgeries for mild-to-moderate adult spinal deformity (ASD) with regard to intensive care unit (ICU) and hospital lengths of stay (LOS).
Methods: A retrospective review of 2 multicenter ASD databases with 426 ASD (sagittal vertical axis <6 cm) surgery patients with 4 or more fusion levels and 2-year follow-up was conducted. ICU stay, LOS, and estimated blood loss (EBL) were compared between open and cMIS surgeries.
Mol Cancer Ther
March 2019
Department of Neurosurgery, Cedars-Sinai Hospital, Los Angeles, California.
A cell culture platform that enables tissue growth from patients or patient-derived xenograft (PDX) models and assesses sensitivity to approved therapies (e.g., temozolomide) in a clinically relevant time frame would be very useful in translational research and personalized medicine.
View Article and Find Full Text PDFAm J Physiol Heart Circ Physiol
April 2019
Diabetes and Obesity Center, University of Louisville, Louisville, Kentucky.
Myocardial ischemia-reperfusion (I/R) results in the generation of free radicals, accumulation of lipid peroxidation-derived unsaturated aldehydes, variable angina (pain), and infarction. The transient receptor potential ankyrin 1 (TRPA1) mediates pain signaling and is activated by unsaturated aldehydes, including acrolein and 4-hydroxynonenal. The contribution of TRPA1 (a Ca-permeable channel) to I/R-induced myocardial injury is unknown.
View Article and Find Full Text PDFJ Orthop Trauma
February 2019
Department of Orthopaedic Surgery, Cedars Sinai Hospital, Los Angeles, CA Los Angeles, CA.
Plast Reconstr Surg Glob Open
December 2018
Division of Plastic Surgery, Department of Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, Calif.
Background: Untreated surgical conditions account for one-third of the total global burden of disease, and a lack of trained providers is a significant contributor to the paucity of surgical care in low- and middle-income countries (LMICs). Wearable technology with real-time tele-proctoring has been demonstrated in high-resource settings to be an innovative method of advancing surgical education and connecting providers, but application to LMICs has not been well-described.
Methods: Google Glass with live-stream capability was utilized to facilitate tele-proctoring between a surgeon in Mozambique and a reconstructive surgeon in the United States over a 6-month period.
Global Spine J
December 2018
Scripps Clinic Torrey Pines, La Jolla, CA, USA.
Study Design: Retrospective, multicenter review of adult scoliosis patients with minimum 2-year follow-up.
Objective: Because the fractional curve (FC) of adult scoliosis can cause radiculopathy, we evaluated patients treated with either circumferential minimally invasive surgery (cMIS) or open surgery.
Methods: A multicenter retrospective adult deformity review was performed.
Am J Perinatol
August 2019
Department of Internal Medicine, UCLA Geffen School of Medicine, Los Angeles, California.
Objective: Allostatic load (AL) represents multisystem physiological "wear-and-tear" reflecting emerging chronic disease risk. We assessed AL during the first year postpartum in a diverse community sample with known health disparities.
Study Design: The Shriver National Institute for Child Health and Human Development Community Child Health Network enrolled 2,448 predominantly low-income African-American, Latina, and White women immediately after delivery of liveborn infants at ≥20 weeks' gestation, following them over time with interviews, clinical measures, and biomarkers.