38 results match your criteria: "Cecina Hospital[Affiliation]"

Early Recurrence and Cerebral Bleeding in Patients With Acute Ischemic Stroke and Atrial Fibrillation: Effect of Anticoagulation and Its Timing: The RAF Study.

Stroke

August 2015

From the Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Italy (M.P., G.A., N.F., V.C., C.B., A.A., M.V., M.A., C.D'A., M.G.M., V.B., I.S.); Neurologia d'urgenza e Stroke Unit, Istituto Clinico Humanitas, Rozzano, Milano, Italy (S. Marcheselli); Abteilung für Neurologie, Oberschwabenklinik gGmbH, Ravensburg, Germany (C.R.); Department of Clinical and Experimental Sciences, Neurology Unit, University "Health and Wealth" of Brescia, Italy (A. Pezzini, L.P., A. Padovani); Stroke Unit, University of Debrecen, Hungary (L.C., L.S.); Department of Neurology, Keimyung University School of Medicine, Daegu, South Korea (S.-I.S.); Stroke Unit-Department of Neurology, Santa Corona Hospital, Pietra Ligure (Savona), Italy (T. Tassinari); Medical School and Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom (A.H.A.-R., K.R.L.); Centre Cérébrovasculaire, Service de Neurologie, Département des Neurosciences Cliniques Centre Hopitalier Universitaire Vaudois, Lausanne, Switzerland (P.M., M. Cordier, S.R.); Department of Neurology, Born Bunge Institute, Antwerp University Hospital, Antwerp, Belgium (P.V.); Stroke Unit, Neuroscience Department, University of Parma, Italy (U.S.); Stroke Unit, Dipartimento Geriatrico Riabilitativo, University of Parma, Italy (L.D.); Clinica Neurologica, Azienda Ospedaliero-Universitaria, Pisa, Italy (G.O., A. Chiti, G.G.); SSO Stroke Unit, UO Neurologia, DAI di Neuroscienze, AOUI Verona, Italy (P.B., M. Carletti, A.R.); Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland (J.P., T. Tatlisumak); Department of Internal Medicine, Cecina Hospital, Cecina, Livorno, Italy (L.M., G.L.); Stroke Unit, AOU Senese, Siena, Italy (R.T., F. Guideri, G. Martini); Department of Neurology, Democritus University of Thrace, University Hospital of Alexandroupolis, Greece (G.T., K.V.); International Clinic Research Center, St. Anne's University Hospital Brno, Brno, Czech

Article Synopsis
  • The study investigates the timing of anticoagulation therapy in patients with acute cardioembolic stroke and atrial fibrillation, focusing on risks for recurrent ischemic events and severe bleeding.
  • Out of 1029 patients, 12.6% experienced adverse events within 90 days, with factors like CHA2DS2-VASc score and type of anticoagulant affecting outcomes.
  • Starting anticoagulants 4 to 14 days after stroke onset is linked to a significant reduction in complications compared to starting before 4 days or after 14 days.
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Objective: There is little evidence to guide treatment strategies for intracerebral hemorrhage on vitamin K antagonists (VKA-ICH). Treatments utilized in clinical practice include fresh frozen plasma (FFP) and prothrombin complex concentrate (PCC). Our aim was to compare case fatality with different reversal strategies.

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C-reactive protein predicts hematoma growth in intracerebral hemorrhage.

Stroke

January 2014

From the Neurological Service, San Camillo de' Lellis General Hospital, Rieti, Italy (M.D.N.); Neurological Section, SMDN-Center for Cardiovascular Medicine and Cerebrovascular Disease Prevention, Sulmona, L'Aquila, Italy (M.D.N., F.P.); Vascular and Stroke Centre, Manchester Academic Health Science Centre, Salford Royal NHS Foundation Trust, Salford, United Kingdom (A.R.P.-J., C.J.S., S.J.H.); SBCHS, Manchester Metropolitan University, Manchester, United Kingdom (M.S.); Institut Català de Ciències Cardiovasculars Hospital de la Santa Creu i Sant Pau, Pavelló del Convent Sant Antoni Maria Claret, Barcelona, Spain (M.S.); Department of Internal Medicine, Cecina Hospital, Cecina, Italy (L.M.); Central Laboratory, Sanatorio Pasteur, Catamarca, Argentina (V.C.); Molecular Genetics Laboratory, Department of Human Genetics, Punjabi University, Patiala, India (P.S.); Research Center for Microscopic Morphology and Immunology & Chair of Biochemistry, University of Medicine and Pharmacy of Craiova, Craiova, Romania (A.P.-W.); Molecular Psychiatry, Department of Psychiatry, Medical University Rostock, Rostock, Germany (A.P.-W.); Department of Neurology, University of Medicine and Pharmacy, Craiova, Romania (V.T.); and Neurocritical Care Unit, Sanatorio Pasteur, and Intensive Care Unit, San Juan Bautista Hospital, Catamarca, Argentina (D.A.G.).

Background And Purpose: Early hematoma growth (EHG) occurs in about one third of patients with spontaneous intracerebral hemorrhage. The main aim of this study was to investigate the potential of plasma C-reactive protein (CRP) for predicting EHG after acute spontaneous intracerebral hemorrhage.

Methods: Plasma CRP was measured within 6 hours of onset (median, 120 minutes) in 399 patients with primary or vitamin K antagonist-associated spontaneous intracerebral hemorrhage and without recent infection.

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Background: In patients with acute pulmonary embolism (PE), the correlation between the embolic burden assessed by multidetector CT (MDCT) scan and clinical outcomes remains unclear. Patients with symptomatic acute PE diagnosed based on MDCT angiography were included in a multicenter study aimed at assessing the prognostic role of the embolic burden evaluated with MDCT scan.

Methods: Embolic burden was assessed as (1) localization of the emboli as central (saddle or at least one main pulmonary artery), lobar, or distal (segmental or subsegmental arteries) and (2) the obstruction index by the scoring system of Qanadli.

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Spontaneous intracerebral hemorrhage (sICH) represents a devastating clinical event with high mortality and morbidity rates. Only few patients with sICH are treated with neurosurgical evacuation of the hematoma, and the majority of them need only a good conservative medical approach. The goal of medical treatment is to avoid secondary neurological and systemic complications.

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Article Synopsis
  • Incidence of oral anticoagulant-associated intracerebral hemorrhage is increasing, posing significant risks of ongoing bleeding, death, or disability in patients using vitamin K1 antagonists.
  • Urgent management focuses on reversing coagulopathy quickly through the discontinuation of anticoagulants and the administration of vitamin K1, prothrombin complex concentrates, or fresh-frozen plasma, as well as life support and potential surgery.
  • There is a lack of strong evidence comparing different reversal strategies, thus emphasizing the need for awareness of current guidelines to avoid legal implications for physicians due to inappropriate treatment approaches.
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Unlabelled: Risk evaluation and prognostic stratification based upon clinical and radiological findings and new cardiac biomarkers, such as natriuretic peptides (NP) and troponins, represent key points in modern management of acute pulmonary embolism (PE). Literature evidence shows that normotensive PE with right heart dysfunction (RHD), defined as submassive PE, has poorer prognosis when compared to normotensive PE without RHD, defined as non-massive PE; thus whether submassive PE should be managed more aggressively and with closer monitoring represents the crucial question about acute PE treatment. Although the answer is yet unclear, the most recent guidelines address to thrombolysis as treatment choice in selected high risk patients with submassive PE.

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Article Synopsis
  • Diagnosis of pulmonary embolism (PE) in the elderly is challenging due to atypical symptoms, leading to missed cases and increased healthcare costs.
  • A review of studies shows that common symptoms in patients over 65 include dyspnea, tachypnea, tachycardia, and chest pain, with risk factors like prolonged bed rest being prevalent.
  • Proposed diagnostic strategies consider the limitations of current tools, especially the variability of D-Dimer effectiveness with age, aiming to improve PE detection in older adults.
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Background And Scope: Recent literature has demonstrated that inflammation contributes to all phases of atherosclerosis and brain damage caused by stroke. In acute phase of cerebrovascular diseases biochemical markers of inflammation, such as C-reactive protein (CRP), could represent an indicator of severity of stroke, but few studies have verified this hypothesis, especially in very old patients. The aim of this study was to evaluate the role of CRP on short- and long-term prognosis in 75-year old and over elderly patients with acute ischaemic stroke.

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