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1,032 results match your criteria: "Catholic University "Sacro Cuore"[Affiliation]"
Retina
December 2024
Ophthalmology Department, "Fondazione Policlinico Universitario A. Gemelli, IRCCS", Rome, Italy.
Purpose: Macular Telangiectasia type 2 (MacTel2) is a rare disorder affecting retina's vascular structure and MacTel2-associated full-thickness macular holes (MHs) are extremely rare in general population. Since their management is still controversial, this literature review aims to gather evidences on the surgical management of MacTel2-associated MHs.
Methods: A retrospective review on the Cochrane Central, PubMed, Web of Science, and ClinicalTrials.
Retina
December 2024
Ophthalmology Department, "Fondazione Policlinico Universitario A. Gemelli, IRCCS", 00168 Rome, Italy.
Purpose: To assess the diagnostic capabilities of the most recent chatbots releases, GPT-4o and Gemini Advanced, facing different retinal diseases.
Methods: Exploratory analysis on 50 cases with different surgical (n=27) and medical (n=23) retinal pathologies, whose optical coherence tomography/angiography (OCT/OCTA) scans were dragged into ChatGPT and Gemini's interfaces. Then, we asked "Please describe this image" and classified the diagnosis as: 1) Correct; 2) Partially correct; 3) Wrong; 4) Unable to assess exam type and 5) Diagnosis not given.
Genome Med
December 2024
Laboratory of Medical Microbiology, Vaccine and Infectious Diseases Institute, University of Antwerp, Antwerp, Belgium.
Background: The impact of community carriage on the influx of extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-E) into hospitals remains understudied. In this prospective 2-year single-centre study, we investigate the community ESBL-E influx and trace the colonisation, nosocomial acquisition, transmission, and infection dynamics of ESBL-producing Escherichia coli (ESBL-Ec) in non-ICU wards at a tertiary care hospital.
Methods: This study reports primary and post hoc outcomes of the clinical trial NCT01208519 in which hospitalised patients were screened for rectal carriage of ESBL-E.
The aim of this study is to investigate the potential of radiomic features extracted from postmortem computed tomography (PMCT) scans of the lateral cerebral ventricles (LCVs) to provide information on the time since death, or postmortem interval (PMI), a critical aspect of forensic medicine. Periodic PMCT scans, referred to as "sequential scans", were obtained from twelve corpses with known times of death, ranging from 5.5 to 273 h postmortem.
View Article and Find Full Text PDFExp Gerontol
December 2024
Postgraduate Program in Physical Education, Federal University of Mato Grosso, Cuiabá, MT, Brazil; Laboratory of Molecular Exercise Physiology - Physical Education Department, University Center - UDF, Brasília, Brazil. Electronic address:
Objective: This study investigated the effects of dual-task resistance training (RT) and detraining on physical function, cognitive capacity, lipid profile, renal function, oxidative stress markers, and chronic inflammation of institutionalized older adults.
Methods: The study involved 11 older adults (83.09 ± 8.
Int J Mol Sci
December 2024
Istituto di Scienze e Tecnologie Chimiche "Giulio Natta", Consiglio Nazionale delle Ricerche, 00168 Rome, Italy.
Glioblastoma multiforme (GBM) is an extremely aggressive brain tumor characterized by a high infiltration capability and recurrence rate. Early diagnosis is crucial to improve the prognosis and to personalize the therapeutic approach. This research explored, by LC-MS proteomic analysis after proteolytic digestion, the molecular profile of pre- and post-operative saliva pools from newly diagnosed (ND) GBM patients by comparing different times of collection and tumor recurrence (R).
View Article and Find Full Text PDFDiagnostics (Basel)
November 2024
Ophthalmology Unit, "Fondazione Policlinico Universitario A. Gemelli IRCCS", 00168 Rome, Italy.
Objectives: To report the occurrence of the regression of the flow signal from the neovascular network in macular neovascularizations (MNVs), developing in the context of age-related macular degeneration (AMD), treated with faricimab in a treat-and-extend regimen.
Methods: Eyes affected by AMD-related MNV and treated with faricimab intravitreal injections in a treat-and-extend (TE) regimen were consecutively retrospectively screened in five specialized retina centers. Changes in neovascular network characteristics during the course of the treatment were analyzed.
Eur J Pediatr
December 2024
Pediatric Neurology, Università Cattolica del Sacro Cuore, Rome, Italy.
Purpose: The availability of care recommendations has improved survival and delayed the progression of clinical signs in Duchenne muscular dystrophy. The aim of the study was to perform a nationwide survey investigating the prevalence, age distribution, and functional status of Duchenne muscular dystrophyin Italy.
Methods: The survey was performed by collecting data from all 31 reference centers for Duchenne muscular dystrophy in Italy using a structured form.
World J Gastrointest Surg
November 2024
Department of General Thoracic Surgery, Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, Università Cattolica del Sacro Cuore, Rome 00168, Italy.
Background: Esophageal perforation or postoperative leak after esophageal surgery remain a life-threatening condition. The optimal management strategy is still unclear.
Aim: To determine clinical outcomes and complications of our 15-year experience in the multidisciplinary management of esophageal perforations and anastomotic leaks.
Mol Psychiatry
December 2024
Univ. Lille, Inserm, CHU Lille, Institut Pasteur de Lille, LabEx DISTALZ - U1167-RID-AGE Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, Lille, France.
Diabetes Metab Res Rev
January 2025
Dipartimento di Neuroscienze, Sezione di Biofisica, Università Cattolica del Sacro Cuore, Rome, Italy.
Aims: This review evaluates the mechanisms underlying red blood cell (RBC) membrane fluidity changes in diabetes mellitus (DM) and explores strategies to assess and address these alterations. Emphasis is placed on developing a comprehensive index for membrane fluidity to improve monitoring and management in diabetic patients.
Materials And Methods: We reviewed current literature on RBC membrane fluidity, focussing on lipid composition, glycation, oxidative stress, and lipid transport alterations in diabetic patients.
Eur J Pediatr
December 2024
Università Cattolica del Sacro Cuore, Rome, 00168, Italy.
Front Surg
November 2024
Unit of Physical and Rehabilitation Medicine, Istituti Clinici Scientifici Maugeri IRCCS, Tradate, Varese, Italy.
Background: Patients with Parkinson's disease (PD) commonly develop severe spinal deformity. The etiology of Parkinson's spinal deformity is not completely understood and in most cases is likely due to multiple factors. These include dystonia and focal myopathy.
View Article and Find Full Text PDFMol Neurobiol
November 2024
Pediatric Neurology, Università Cattolica del Sacro Cuore, Rome, Italy.
Spinal muscular atrophy (SMA) is a neuromuscular disorder resulting in the loss of α-motor neurons. Nusinersen is an antisense oligonucleotide administered intrathecally to SMA patients that corrects the splicing defect of SMN2. Not all SMA patients respond equally to the therapy and work is in progress to identify biomarkers that may help stratify to SMA patients.
View Article and Find Full Text PDFFront Horm Res
November 2024
Neurosurgery Unit, Department of Neurosciences, Catholic University School of Medicine, Rome, Italy.
Acromegaly and gigantism are rare diseases, usually caused by a growth hormone-secreting pituitary adenoma, recently renamed GH-secreting pituitary neuroendocrine tumor (GH-PitNET). The transsphenoidal approach is the mainstay of treatment, although a non-negligible number of patients require a multimodal approach with neo-adjuvant or adjuvant medical and radiation therapy. Understanding the clinical complexity of acromegaly and gigantism is essential to improve treatment safety and success.
View Article and Find Full Text PDFFront Cell Dev Biol
November 2024
Laboratory of Preclinical and Translational Research, Centro di Riferimento Oncologico della Basilicata (IRCCS-CROB), Rionero inVulture, Italy.
Support Care Cancer
November 2024
UOC di Radioterapia Oncologica, Dipartimento Diagnostica per Immagini, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Radioterapia Oncologica Ed Ematologia, Rome, Italy.
Purpose: This study investigated the prevalence and determinants of psychosocial distress among hospitalized patients undergoing radiotherapy to identify opportunities for interventions to enhance patient well-being.
Methods: Between January 2021 and May 2023, 137 hospitalized patients received radiotherapy treatment at the Department of Radiation Oncology of the Fondazione A. Gemelli IRCCS were recruited.
Surv Ophthalmol
November 2024
Ophthalmology Unit, "Fondazione Policlinico Universitario A. Gemelli IRCCS", Rome, Italy; Catholic University "Sacro Cuore", Rome, Italy; Neuroscience Institute, Italian National Research Council, CNR, Pisa, Italy.
Age-related macular degeneration (AMD) is a leading cause of blindness and visual impairment worldwide. Structural en face optical coherence tomography (OCT) is an innovative imaging technology that has recently attracted interest because of its potential for assessing AMD features. We conducted a comprehensive review of its application in AMD.
View Article and Find Full Text PDFJ Affect Disord
February 2025
Department of Neuroscience, Section of Psychiatry, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168 Rome, Italy; Department of Psychiatry, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Largo Agostino Gemelli 8, 00168 Rome, Italy. Electronic address:
Objective: Childhood trauma is a significant environmental stressor linked to mood disorder. It can affect not only the individuals directly involved but also the next generation through the intergenerational transmission of trauma. This study aimed to investigate, for the first time, the co-occurrence of childhood trauma in youths with mood disorders and their parents.
View Article and Find Full Text PDFGraefes Arch Clin Exp Ophthalmol
November 2024
Instituto de Microcirugía Ocular (IMO), Barcelona, Spain.
Purpose: To assess functional and anatomical outcomes of internal limiting membrane (ILM) inverted flap in highly myopic macular holes (HMMHs) with outer-retinoschisis (O-RS).
Methods: Retrospective interventional analysis of 19 eyes with HMMH and O-RS undergoing vitrectomy and ILM inverted flap. At baseline and every follow-up visit (1, 3, 6, 12 months and the most recent) we performed best-corrected visual acuity (BCVA, Snellen) and optical coherence tomography (OCT), collecting several parameters: minimum linear diameter (MLD), basal diameter (BD), peri-HMMH nasal and temporal retinal thickness (RT and RT), peri-HMMH nasal and temporal O-RS height (O-RS and O-RS).
J Clin Med
November 2024
Department of Ophthalmology, Sankara Eye Hospital, Jaipur 302039, Rajasthan, India.
: We report a case of brainstem anesthesia (BSA) and subsequent cardiac arrest following a routinary peribulbar block (PB) in a patient scheduled for cataract extraction and intraocular lens (IOL) implantation, thus providing a reference for further analysis of this potentially catastrophic life-threatening complication and to evaluate the current knowledge in terms of incidence, physiopathology management, and treatment of the BSA following PB. : Three databases (PubMed, Embase, and Scopus) were checked to perform a systematic review of all available studies in the English Language following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to evaluate relevant studies that clearly described BSA following BSA. : Our literature search identified 15 cases.
View Article and Find Full Text PDFUrologia
November 2024
Postgraduate School of Urology, Università Cattolica del Sacro Cuore, Rome, Italy.
Introduction: Benign prostatic hyperplasia (BPH) is a prevalent urological condition leading to lower urinary tract symptoms. Minimal invasive surgical treatment (MISTs) such as Rezūm System are emerging aiming to relieve symptoms. We present results from a single centre prospective study.
View Article and Find Full Text PDFIntroduction: The central biochemical cause of gout is hyperuricemia (elevated serum urate levels). Ultrasound features of monosodium urate (MSU) crystal deposition are common in people with asymptomatic hyperuricemia. However, it is unclear whether this is a precondition for the development of gout.
View Article and Find Full Text PDFAm J Ophthalmol Case Rep
December 2024
Instituto de Microcirugía Ocular (IMO), Barcelona, Spain.
Purpose: We report a case of retinal toxicity induced by SBP-101, a polyamine inhibitor for the treatment of metastatic pancreatic adenocarcinoma, presenting as rapidly progressive bilateral central retinal pigmented epithelium (RPE) atrophy in a patient with a silent ocular history.
Observations: A 69-year-old female patient with a metastatic pancreatic adenocarcinoma visited our retina clinic referring a 6-months history of blurred vision and progressive visual field loss. One year before, she started administration of SBP-101 combined with nab-paclitaxel and gemcitabine to treat her malignancy.
Nat Commun
October 2024
Department of Mathematics and Physics, Università Cattolica del Sacro Cuore, Brescia, Italy.
Avalanche resistive switching is the fundamental process that triggers the sudden change of the electrical properties in solid-state devices under the action of intense electric fields. Despite its relevance for information processing, ultrafast electronics, neuromorphic devices, resistive memories and brain-inspired computation, the nature of the local stochastic fluctuations that drive the formation of metallic regions within the insulating state has remained hidden. Here, using operando X-ray nano-imaging, we have captured the origin of resistive switching in a VO-based device under working conditions.
View Article and Find Full Text PDF