441 results match your criteria: "Catania University.[Affiliation]"

Article Synopsis
  • - Age-related macular degeneration (AMD) is a major cause of vision loss in older adults, and currently, there are no effective drugs to treat it.
  • - Research is exploring the use of stem cells to replace damaged retinal cells, specifically targeting retinal pigment epithelium (RPE) for potential therapy.
  • - This chapter reviews key clinical trials and protocols on using stem cell therapy for AMD, detailing how the progression of the disease and treatment responses have been monitored.
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Background: Temporomandibular disorders (TMDs) encompass a spectrum of orofacial conditions characterised by pain and dysfunction in the temporomandibular joint and surrounding structures. Tobacco smoking has been posited as a potential factor influencing the prevalence and intensity of TMD. However, the nature and extent of this relationship remain unclear due to variations in study outcomes.

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  • * The authors conducted a literature search that yielded 21 relevant studies from PubMed, focusing on the characteristics of the ocular surface and the microbiome's role in glaucoma.
  • * Key topics discussed include the anatomy of the eye, the effects of microbial imbalance (dysbiosis), immune responses, and future treatment strategies that could benefit ocular health by targeting the microbiome.
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  • The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has impacted not only the respiratory system but also various eye-related conditions, demonstrating a range of ocular symptoms.
  • Important eye manifestations of COVID-19 include conjunctivitis, scleritis, uveitis, and retinopathy, making it crucial for eye care practitioners to monitor these signs as potential early indicators of the disease.
  • The review also discusses how the virus interacts with ocular tissues and examines vaccine-related ocular side effects, highlighting the necessity for continued research on vaccine safety and effective eye examinations for COVID-19 patients.
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Proliferative vitreoretinopathy (PVR) has traditionally been managed with vitreoretinal surgery. Although there have been several recent innovations in this surgery to make the retinal approach as uninvasive as possible, the outcomes remain unsatisfactory. Significant complications remain and the complexity of the surgical approach is challenging.

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Background: Glaucoma is a major cause of incurable ocular morbidity and poses significant challenges in its management due to the limited treatment options and potential adverse effects. Nicotinamide, a naturally occurring diet-rich nutrient, has emerged as a promising therapeutic agent for glaucoma, offering neuroprotective effects and the potential modulation of intraocular pressure (IOP) regulation pathways. This comprehensive review sought to analyze the current literature on nicotinamide in glaucoma management, exploring its mechanisms of action, efficacy, and safety profile.

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Trial Design: This is a prospective, block-randomized, blinded, multiple arm and parallel-group superiority clinical trial.

Methods: Seventy-eight patients satisfying the recruitment standards, were randomly allocated into three groups as follows: Group I (n = 26) - Inferior alveolar nerve block (IANB) devoid of aromatherapy (AT); Group II (n = 26) - IANB with lavender AT and Group III - IANB with rose AT (n = 26) with the help of the ultrasonic aroma diffuser (with respective oils)for 20 min/2 h in operatories 1,2 and 3 respectively. For AT, 3-4 drops of lavender and rose-conditioned oils were added from a 100 ml solution containing 100 mg of these medicinal plants.

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A talented giant: a tribute to the memory of John M. Opitz.

Ital J Pediatr

August 2024

Section of Pediatrics and Child Neuropsychiatry, Department of Child and Experimental Medicine, Catania University, Catania, Italy.

Background: John M. Opitz, a towering figure in both stature and scientific achievement, left an indelible mark on the fields of genetics, pediatrics, and embryology. Born in 1935 in Hamburg to a Jewish family, Opitz's early life was marked by adversities.

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Inter-appointment pain (IAP) is a subtype of postoperative pain which occurs between endodontic appointments. It may begin within a few hours after the first appointment and may continue for several days. Apart from mechanical instrumentation and thorough irrigation, intracanal medicaments play a central role in the disinfection of root canals and thus decreasing IAP.

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Article Synopsis
  • The Sicilian Regional Health System has implemented direct management procedures for medical malpractice claims, emphasizing sentinel event monitoring to enhance patient safety and reduce insurance costs.
  • A 28-year-old woman underwent laparoscopic surgery for uterine fibroids, but later discovered she had leiomyosarcoma after complications, ultimately leading to her death six months post-diagnosis.
  • The case raises concerns about informed consent, the use of the risky morcellation technique, and potential misdiagnosis, suggesting possible medical malpractice by the healthcare providers involved.
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  • Thyroid Eye Disease (TED) is a serious autoimmune condition linked with thyroid issues, leading to significant eye problems and discomfort.
  • Recent breakthroughs in TED treatment include Teprotumumab, the first FDA-approved medication specifically for the disease, which effectively reduces inflammation and improves patient quality of life.
  • Management of TED requires a team of specialists and includes advancements in both medical treatments and surgical techniques, ensuring comprehensive care for affected patients.
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Article Synopsis
  • More people around the world are having serious eye problems that affect their vision due to conditions like diabetes and other health issues.
  • Scientists and doctors are exploring new technology and AI to help find and diagnose these eye diseases faster and more accurately.
  • Using AI can make it easier for doctors to help patients, especially those who live far away, by quickly spotting problems and suggesting the right treatments.*
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Background: Obstructive sleep apnea (OSA) is a prevalent sleep disorder characterized by repeated episodes of partial or complete obstruction of the upper airway during sleep. While the systemic implications of OSA are well documented, the dental consequences are less frequently discussed yet equally significant. This review aims to elucidate the oral health impacts of OSA, emphasizing the importance of interdisciplinary care.

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Background: Temporomandibular disorders (TMDs) are musculoskeletal and neuromuscular conditions affecting the temporomandibular joint and associated structures. Cognitive-behavioural therapy (CBT) has emerged as a potential intervention for TMDs, but its comparative effectiveness against standard treatments remains unclear. This systematic review aimed to evaluate and compare the efficacy of CBT versus standard treatment interventions in managing TMDs.

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Quantum control techniques are one of the most efficient tools for attaining high-fidelity quantum operations and a convenient approach for quantum sensing and quantum noise spectroscopy. In this work, we investigate dynamical decoupling while processing an entangling two-qubit gate based on an Ising-xx interaction, each qubit affected by pure dephasing classical correlated 1/f-noises. To evaluate the gate error, we used the Magnus expansion introducing generalized filter functions that describe decoupling while processing and allow us to derive an approximate analytic expression as a hierarchy of nested integrals of noise cumulants.

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Background: Temporomandibular disorders (TMDs) pose diagnostic challenges, and selecting appropriate imaging modalities is crucial for accurate assessment. This study aimed to compare the diagnostic accuracy and efficacy of ultrasonography (US) and magnetic resonance imaging (MRI) in identifying TMDs.

Methods: A comprehensive meta-analysis was conducted, including studies that compared US and MRI for TMJ disorder assessments.

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Sensitivity of different part-mouth recording methods using a modified tooth wear index.

Minerva Dent Oral Sci

July 2024

Multidisciplinary Department of Medical-Surgical and Odontostomatological Specialties, Luigi Vanvitelli University of Campania, Naples, Italy -

Background: High prevalence of tooth wear (TW) worldwide makes it important to assess its level in different populations. In developing countries, a shift towards geriatric population makes the evaluation of this condition even more relevant. Most indices for tooth wear are full mouth indices, which make mass population screening challenging.

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Micronuclei as an indicator of genotoxic change in epithelial cells of buccal mucosa after panoramic radiographs.

Technol Health Care

July 2024

Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai, India.

Background: The radiation released at the time of dental panoramic radiographs causes genotoxic and cytotoxic effects on epithelial cells.

Objective: This research aimed to evaluate the changes in the frequencies of micronucleated cells in patients' buccal epithelial cells following dental panoramic radiography.

Methods: 74 patients were recruited for the study who were advised for panoramic radiographs.

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Development and initial validation of parent and child versions of the Juvenile Arthritis Disease Activity Score.

Rheumatology (Oxford)

July 2024

IRCCS Istituto Giannina Gaslini, U.O.C. Centro Malattie autoinfiammatorie e Immunodeficienze, Genoa, Italy.

Objective: To develop parent- and child-centered versions of the Juvenile Arthritis Disease Activity Score (JADAS) and to provide preliminary evidence of their validity.

Methods: Validation analyses were conducted on two large multinational datasets of patients with juvenile idiopathic arthritis (JIA) and included assessment of construct validity, internal consistency and structure, discriminative validity, responsiveness to change, and predictive validity.

Results: The parJADAS and patJADAS include four parent/patient-reported outcomes, each measured on a 0-10 scale: assessment of overall disease activity; rating of pain intensity; assessment of activity of joint disease; duration of morning stiffness.

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Article Synopsis
  • - Whole-eye transplantation presents a revolutionary potential for treating irreversible blindness, but significant challenges remain, particularly in preserving donor eye health and achieving successful optic nerve regeneration.
  • - Key hurdles include developing effective surgical techniques to maintain retinal integrity, enhancing neurotrophic support for nerve healing, and addressing the unique immune reactions associated with eye tissue to ensure graft acceptance.
  • - Ongoing interdisciplinary research is vital, focusing on innovations like biomaterials and stem cell therapies, while ethical and legal standards are essential to guide this emerging field towards successfully restoring vision and improving patients' lives.
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Primary open angle glaucoma (POAG) is defined as a "genetically complex trait", where modifying factors act on a genetic predisposing background. For the majority of glaucomatous conditions, DNA variants are not sufficient to explain pathogenesis. Some genes are clearly underlying the more "Mendelian" forms, while a growing number of related polymorphisms in other genes have been identified in recent years.

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Background: As one of the most common aesthetic surgical procedures carried out today, blepharoplasty should be in the repertoire of every plastic surgeon. The term blepharoplasty encompasses a wide range of techniques and options that must be tailored to the specific defect and patient one has to treat. A sound knowledge of the upper and lower eyelids' anatomy is essential for proper surgical execution.

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The aging of the periocular region has always aroused great interest. A fresh, young, and attractive sight determined an ever-greater attention to surgical and non-surgical techniques to obtain this result. In particular, the change in the concept of a young look, considered then "full", led to the increasing use of surgical (fat grafting) or medical (hyaluronic acid) filling techniques.

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The main motivation for this research was to improve the properties of geopolymers by reinforcement using synthetic and natural fibers, and to gain new knowledge regarding how the nature and/or the quantity of reinforcement fibers influences the properties of the final geopolymers. The main objective was to investigate the effects of different types of reinforcement fibers on the properties of the geopolymers. These reinforcement fibers were mainly environmentally friendly materials that can be used as alternatives to ordinary Portland cement.

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