Basic Science and Pathogenesis.

Background: Mitochondrial dysfunction plays a critical role in the pathogenesis of Alzheimer's disease (AD). Mitochondrial proteostasis regulated by chaperones and proteases in each compartment of mitochondria is critical for mitochondrial function, and it is suspected that mitochondrial proteostasis deficits may be involved in mitochondrial dysfunction in AD.

Method: An unbiased screening of intraneuronal Aβ42 protein-interactome was perfumed in AD cell culture.