Extrapulmonary small-cell carcinoma: report of three cases and update of therapy and prognosis.

Three male patients with extrapulmonary small-cell carcinoma originating from esophagus, pancreas and prostate are described. The patient with the esophagus tumor had a combined small-cell and undifferentiated carcinoma. The other two patients had a pure small-cell carcinoma.

Adverse reactions to fragrances. A clinical review.

This article reviews side-effects of fragrance materials present in cosmetics with emphasis on clinical aspects: epidemiology, types of adverse reactions, clinical picture, diagnostic procedures, and the sensitizers. Considering the ubiquitous occurrence of fragrance materials, the risk of side-effects is small. In absolute numbers, however, fragrance allergy is common, affecting approximately 1% of the general population.

Methyldibromoglutaronitrile (Euxyl K 400): an important "new" allergen in cosmetics.

Euxyl K 400 is a preservative system for cosmetics and toiletries that contains phenoxyethanol and methyldibromoglutaronitrile in a 4:1 ratio. In The Netherlands, Italy, and Germany, the prevalence of allergy to Euxyl K 400 has risen in the past 4 years and is currently 2% to 4% in patients suspected of having contact dermatitis. The allergenic ingredient is nearly always methyldibromoglutaronitrile.

Is lipoatrophia semicircularis induced by pressure?

Ten patients suffering from lipoatrophia semicircularis are reported. It is suggested that pressure from a chair on the posterior aspect of the thighs, possibly in combination with direct pressure from a desk on the anterior aspect, caused the condition in these patients. Lipoatrophia semicircularis may be quite common, but most patients do not present to a dermatologist.