Kinematic analysis of an unrestrained passenger in an autonomous vehicle during emergency braking.

Analyzing human body movement is a critical aspect of biomechanical studies in road safety. While most studies have traditionally focused on assessing the head-neck system due to the restraint provided by seat belts, it is essential to examine the entire pelvis-thorax-head kinematic chain when these body regions are free to move. The absence of restraint systems is prevalent in public transport and is also being considered for future integration into autonomous vehicles operating at low speeds.

Biomarkers of Bipolar Disorder in Late Life: An Evidence-Based Systematic Review.

Purpose Of Review: Review the current evidence on biomarkers for bipolar disorder in the older adults. We conducted a systematic search of PubMed MEDLINE, PsycINFO, and Web of Science databases using the MeSH search terms "Biomarkers", "Bipolar Disorder", "Aged" and and "Aged, 80 and over". Studies were included if they met the following criteria: (1) the mean age of the study population was 50 years old or older, (2) the study included patients with bipolar disorder, and (3) the study examined one type of biomarkers or more including genetic, neuroimaging, and biochemical biomarkers.

Food drugs as drivers of therapeutic knowledge and the role of chemosensory qualities.

Ethnopharmacological Relevance: Chemosensory qualities of botanical drugs are important cues for anticipating physiologic consequences. Whether a botanical drug is used for both, food and medicine, or only as medicine depends on taste preferences, nutritional content, cultural background, and the individual and overall epidemiological context.

Material And Methods: We subjected 540 botanical drugs described in De Materia Medica having at least one oral medical application to a tasting panel.

Feasibility Study of Experimental Protocol for the Time-Dependent Mechanical Response of Synthetic Tibia.

In this research, an experimental biomechanics construct was developed to reveal the mechanics of distal tibial fracture by submitting synthetic tibiae to cyclic loading, resulting in a combined stress state due to axial compression and bending loads. The synthetic tibia was fixed at the knee but allowed to rotate in the coronal and sagittal planes at the ankle. The first three loading regimes lasted for 4000 cycles/each, and the final until ultimate failure.

Degradation of Mechanical Properties of Flax/PLA Composites in Hygrothermal Aging Conditions.

The main advantage of green composites is their biodegradability, but this biodegradability can also be considered a drawback if the degradation appears during the service life of the component. Therefore, the study of the mechanical behavior of green composites after hygrothermal aging tests is necessary to analyze their degradation process. This study aims to comprehensively analyze the hygrothermal aging behavior and aging mechanism of flax-fiber-reinforced polylactic acid (PLA) biocomposites.

Corrigendum: Personalized monitoring of circulating tumor DNA with a specific signature of trackable mutations after chimeric antigen receptor T-cell therapy in follicular lymphoma patients.

[This corrects the article DOI: 10.3389/fimmu.2023.

First-in-human demonstration of floating EMG sensors and stimulators wirelessly powered and operated by volume conduction.

Background: Recently we reported the design and evaluation of floating semi-implantable devices that receive power from and bidirectionally communicate with an external system using coupling by volume conduction. The approach, of which the semi-implantable devices are proof-of-concept prototypes, may overcome some limitations presented by existing neuroprostheses, especially those related to implant size and deployment, as the implants avoid bulky components and can be developed as threadlike devices. Here, it is reported the first-in-human acute demonstration of these devices for electromyography (EMG) sensing and electrical stimulation.

Automatic Detection of Magnetic Disturbances in Magnetic Inertial Measurement Unit Sensors Based on Recurrent Neural Networks.

This paper proposes a new methodology for the automatic detection of magnetic disturbances from magnetic inertial measurement unit (MIMU) sensors based on deep learning. The proposed approach considers magnetometer data as input to a long short-term memory (LSTM) neural network and obtains a labeled time series output with the posterior probabilities of magnetic disturbance. We trained our algorithm on a data set that reproduces a wide range of magnetic perturbations and MIMU motions in a repeatable and reproducible way.

Predicting the effectiveness of drugs used for treating cardiovascular conditions in newborn infants.

Background: Cardiovascular support (CVS) treatment failure (TF) is associated with a poor prognosis in preterm infants.

Methods: Medical charts of infants with a birth weight <1500 g who received either dopamine (Dp) or dobutamine (Db), were reviewed. Treatment response (TR) occurred if blood pressure increased >3rd centile for gestational age or superior vena cava flow was maintained >55 ml/kg/min, with decreased lactate or less negative base excess, without additional CVS.

Brightening and Directionality Control of Dark Excitons through Quasi-Bound States in the Continuum.

Thanks to their long lifetime, spin-forbidden dark excitons in transition metal dichalcogenides are promising candidates for storage applications in opto-electronics and valleytronics. To date, their study has been hindered by inefficient generation mechanisms and the necessity for elaborate detection schemes. In this work, we propose a new hybrid platform that simultaneously addresses both challenges.

Photoluminescence Enhancement of Monolayer WS by n-Doping with an Optically Excited Gold Disk.

In nanophotonics and quantum optics, we aim to control and manipulate light with tailored nanoscale structures. Hybrid systems of nanostructures and atomically thin materials are of interest here, as they offer rich physics and versatility due to the interaction between photons, plasmons, phonons, and excitons. In this study, we explore the optical and electronic properties of a hybrid system, a naturally n-doped monolayer WS covering a gold disk.

Concordance and validity between versions of the ADHD Conners scale for Parents.

Introduction: The Conners Scale for Parents (CRS-P) is one of the reference tools for the diagnostic assessment of Attention Deficit and Hyperactivity Disorders (ADHD). It is commonly used in both research and clinical practice. The latest edition of the Conners Parents Scale Long Version (CRS-P3L) has undergone extensive modifications but has never been compared with the 2nd edition (CRS-P2L).

Corrigendum: Personalized monitoring of circulating tumor DNA with a specific signature of trackable mutations after chimeric antigen receptor T-cell therapy in follicular lymphoma patients.

[This corrects the article DOI: 10.3389/fimmu.2023.

Personalized monitoring of circulating tumor DNA with a specific signature of trackable mutations after chimeric antigen receptor T-cell therapy in follicular lymphoma patients.

Background: CART therapy has produced a paradigm shift in the treatment of relapsing FL patients. Strategies to optimize disease surveillance after these therapies are increasingly necessary. This study explores the potential value of ctDNA monitoring with an innovative signature of personalized trackable mutations.

Design of an algorithm for the detection of intravenous fluid contamination in clinical laboratory samples.

Objectives: Contamination of blood samples from patients receiving intravenous fluids is a common error with potential risk to the patient. Algorithms based on the presence of aberrant results have been described but have the limitation that not all infusion fluids have the same composition. Our objective is to develop an algorithm based on the detection of the dilution observed on the analytes not usually included in infusion fluids.

Experimental Validation of High Spatial Resolution of Two-Color Optical Fiber Pyrometer.

Taking non-contact temperature measurements in narrow areas or confined spaces of non-uniform surfaces requires high spatial resolution and independence of emissivity uncertainties that conventional cameras can hardly provide. Two-color optical fiber (OF) pyrometers based on standard single-mode (SMF) and multi-mode optical fibers (MMF) with a small core diameter and low numerical aperture in combination with associated commercially available components can provide a spatial resolution in the micrometer range, independent of the material's emissivity. Our experiment involved using a patterned microheater to generate temperatures of approximately 340 °C on objects with a diameter of 0.

Untargeted metabolomic study by liquid chromatography-mass spectrometry in brain tissues on the effects of combined cocaine and ethanol self-administration in male and female young rats.

The combined use of ethanol and cocaine is frequent among drug-abuse users and leads to further exacerbation of health consequences compared to individual consumption and this is of special concern during the transition to adulthood. Despite its high prevalence, the effect of combined consumption of cocaine and ethanol has been scarcely studied. In this work, we report the first untargeted metabolomic study in brain tissues to contribute to the advancement in the knowledge of the possible neurobiological effects of this polysubstance dependence.

A Multi-Criteria Decision Aid Tool for Radiopharmaceutical Selection in Tau PET Imaging.

The accumulation of pathologically misfolded tau is a feature shared by a group of neurodegenerative disorders collectively referred to as tauopathies. Alzheimer's disease (AD) is the most prevalent of these tauopathies. Immunohistochemical evaluation allows neuropathologists to visualize paired-helical filaments (PHFs)-tau pathological lesions, but this is possible only after death and only shows tau in the portion of brain sampled.

Capability of Copper Hydroxy Nitrate (Cu(OH)NO) as an Additive to Develop Antibacterial Polymer Contact Surfaces: Potential for Food Packaging Applications.

The globalization of the market, as well as the increasing world population, which require a higher demand for food products, pose a great challenge to ensure food safety and prevent food loss and waste. In this sense, active materials with antibacterial properties are an important alternative in the prolongation of shelf life and ensuring food safety. In this work, the ability of copper(II) hydroxy nitrate (CuHS) to obtain antibacterial films based on low density polyethylene (LDPE) and polylactic acid (PLA), was evaluated.

COVID-19 Prediction Using Black-Box Based Pearson Correlation Approach.

The novel coronavirus (COVID-19), also known as SARS-CoV-2, is a highly contagious respiratory disease that first emerged in Wuhan, China in 2019 and has since become a global pandemic. The virus is spread through respiratory droplets produced when an infected person coughs or sneezes, and it can lead to a range of symptoms, from mild to severe. Some people may not have any symptoms at all and can still spread the virus to others.