Varicella zoster vasculopathy causing recurrent ischaemic strokes in an immunocompetent patient.

A 66-year-old woman reported 10 days of generalised weakness, falls and memory 'glitches'. She had developed left-sided ophthalmic herpes zoster 3 months before but was otherwise well. MR scan of brain showed acute left-sided ischaemic strokes and CT cerebral angiogram identified marked stenoses of the left anterior and middle cerebral arteries.

Enhancing Efficiency with an AI-Augmented Clinician in Neurology.

Integrating artificial intelligence (AI) technologies into neurology promises increased patient access, engagement, and quality of care, as well as improved quality of work life for clinicians. While most studies have focused on comparing AI models to expert performance, we argue for a more practical approach: demonstrating how AI can augment clinical practice. This article presents a framework for pragmatic AI augmentation, addressing the shortage in neurology practices, exploring the potential of AI in opportunistic screening, and encouraging the concept of AI serving as a "co-pilot" in neurology.

Gender and speech material effects on the long-term average speech spectrum, including at extended high frequencies.

Gender and language effects on the long-term average speech spectrum (LTASS) have been reported, but typically using recordings that were bandlimited and/or failed to accurately capture extended high frequencies (EHFs). Accurate characterization of the full-band LTASS is warranted given recent data on the contribution of EHFs to speech perception. The present study characterized the LTASS for high-fidelity, anechoic recordings of males and females producing Bamford-Kowal-Bench sentences, digits, and unscripted narratives.

Network interactions simultaneously enhance stiffness and lubricity of triple-network hydrogels.

Synthetic hydrogels displaying cartilage-mimetic bulk and surface properties may serve as cartilage substitutes. Multi-network, electrostatic hydrogels that leverage intra- and inter-network repulsive and attractive forces represent a promising approach. Herein, triple network (TN) hydrogels were prepared to obtain a combination of desired characteristics (, hydration, stiffness, shear stress, and friction properties).

Kidney toxicology of a novel compound Lithium Bis(trifluoromethanesulfonyl)imide (LiTFSI, ie. HQ-115) used in energy applications: An epigenetic perspective.

Exposure to emerging energy-based environmental contaminants such as lithium bis(trifluoromethanesulfonyl)imide (LiTFSI, trade name HQ-115), poses a significant threat to human health, yet its impact on kidney function and epigenetic regulation remains poorly understood. Here, we investigated the effects of LiTFSI exposure on kidney-related biochemical indicators, renal injuries, and epigenetic alterations in male CD-1 mice under both 14-day and 30-day exposure durations. Our study revealed that LiTFSI exposure led to changes in kidney-related markers, notably affecting serum bicarbonate levels, while relative kidney weight remained unaffected.

A Unique Case of Pregnancy-Associated Spontaneous Coronary Artery Dissection Presenting As Generalized Tonic-Clonic Seizure.

Spontaneous coronary artery dissection (SCAD) is an uncommon form of non-atherosclerotic coronary artery disease, characterized by a sudden tear in coronary artery layers. Pregnancy-associated SCAD (P-SCAD) is a rare variant occurring during pregnancy or postpartum. We present a case of P-SCAD in a 31-year-old postpartum female who experienced generalized tonic-clonic seizures along with ventricular fibrillation.

Novel repurposing of sulfasalazine for the treatment of adrenocortical carcinomas, probably through the SLC7A11/xCT-hsa-miR-92a-3p-OIP5-AS1 network pathway.

Background: Recent multigenomic analysis of adrenocortical carcinomas (ACCs) identified SLC7A11/xCT as a novel biomarker. The Food and Drug Administration-approved anti-inflammatory drug, sulfasalazine (SAS), induces ferroptosis by blocking SLC7A11 expression. We hypothesize that SAS could be repurposed to target ACC cells.

On the design and fabrication of nanoliter-volume hanging drop networks.

Hanging drop cultures provide a favorable environment for the gentle, gel-free formation of highly uniform three-dimensional cell cultures often used in drug screening applications. Initial cell numbers can be limited, as with primary cells provided by minimally invasive biopsies. Therefore, it can be beneficial to divide cells into miniaturized arrays of hanging drops to supply a larger number of samples.

Endovascular repair of infrarenal abdominal aortic aneurysm combined with aneurysmectomy and interposition bypass for left common femoral artery aneurysm.

Femoral artery aneurysms (FAAs) can occur in some patients with abdominal aortic aneurysms. There is a lack of natural history studies in the published literature. Guidelines recommend FAA repair when symptomatic or larger than 2.

Feasibility and acceptability pilot study of an online weight loss program in rural, underserved communities.

Background: The purpose of this intervention was to investigate the feasibility, acceptability, and preliminary effectiveness of an online weight loss program, EMPOWER, in rural, underserved communities.

Methods: Adults with a body mass index (BMI) ≥ 25 kg/m living in rural counties were recruited through collaboration with University of Illinois Extension. The intervention lasted 1 year including online educations sessions, nutrition and lifestyle coaching, and diet and weight monitoring a novel web application, MealPlot.

Temperature-jump microscopy and interaction of Hsp70 heat shock protein with a client protein in vivo.

Biomolecular processes such as protein-protein interactions can depend strongly on cell type and even vary within a single cell type. Here we develop a microscope with a Peltier-controlled temperature stage, a laser temperature jump to induce heat stress, and an autofocusing feature to mitigate temperature drift during experiments, to study a protein-protein interaction in a selected cell type within a live organism, the zebrafish larva. As an application of the instrument, we show that there is considerable cell-to-cell variation of the heat shock protein Hsp70 binding to one of its clients, phosphoglycerate kinase in vivo.

Tai Chi Practice Buffers Aging Effects in Functional Brain Connectivity.

Tai Chi (TC) practice has been shown to improve both cognitive and physical function in older adults. However, the neural mechanisms underlying the benefits of TC remain unclear. Our primary aims are to explore whether distinct age-related and TC-practice-related relationships can be identified with respect to either temporal or spatial (within/between-network connectivity) differences.

Lifetime history of head injury is associated with reduced perivascular space number in acute mild traumatic brain injury.

Traumatic brain injury impairs function of the glymphatic system, a perivascular network involved in waste clearance. Enlarged perivascular spaces visible on MRI are an emerging biomarker of glymphatic function. This study characterized enlarged perivascular spaces in acute head injury with 7 T MRI.

Plastic Surgery Waste Management: Going Green, Makes Green?

Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.

ARHGEF3 Regulates Hair Follicle Morphogenesis.

During embryogenesis, cells arrange into precise patterns that enable tissues and organs to develop specialized functions. Despite its critical importance, the molecular choreography behind these collective cellular behaviors remains elusive, posing a major challenge in developmental biology and limiting advances in regenerative medicine. By using the mouse hair follicle as a mini-organ system to study the formation of bud-like structures during embryonic development, our work uncovers a crucial role for the Rho GTPase regulator ARHGEF3 in hair follicle morphogenesis.

Class in Session: Analysis of GPT-4-created Plastic Surgery In-service Examination Questions.

Background: The Plastic Surgery In-Service Training Examination (PSITE) remains a critical milestone in residency training. Successful preparation requires extensive studying during an individual's residency. This study focuses on the capacity of Generative Pre-trained Transformer 4 (GPT-4) to generate PSITE practice questions.