2 results match your criteria: "Cardiovascular and Renal Research University of Southern Denmark Odense Denmark.[Affiliation]"
Mitochondrial reactive oxygen species modify extracellular vesicles secretion rate.
FASEB Bioadv
September 2023
Department of Molecular Medicine, Cardiovascular and Renal Research University of Southern Denmark Odense Denmark.
Article Synopsis
- Hypoxia boosts the secretion rate of extracellular vesicles (EVs) by increasing reactive oxygen species (ROS) through the mitochondrial electron transport chain (ETC) and hypoxia-induced factor (HIF)-1 signaling, but their exact roles in this process were previously unclear.* -
- The study found that while the HIF-1α stabilizer roxadustat did not affect EV secretion, stimulation of the ETC with dichloroacetic acid (DCA) significantly increased EV release, but this was blocked by the antioxidant TEMPO and the Complex I inhibitor rotenone.* -
- Inhibition of Complex III under hypoxic conditions and early steps in the mevalonate pathway enhanced ROS-dependent EV secretion,
Background Published randomized controlled trials are underpowered for binary clinical end points to assess the safety and efficacy of renin-angiotensin system inhibitors (RASi) in adults with COVID-19. We therefore performed a meta-analysis to assess the safety and efficacy of RASi in adults with COVID-19. Methods and Results MEDLINE, EMBASE, ClinicalTrials.
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