2 results match your criteria: "Cardiovascular Endocrinology LaboratoryUniversity of Ottawa Heart Institute[Affiliation]"
Go protein subunit Goα and the secretory process of the natriuretic peptide hormones ANF and BNP.
J Mol Endocrinol
June 2015
Cardiovascular Endocrinology LaboratoryUniversity of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario, Canada K1Y 4W7Department of Pathology and Laboratory MedicineFaculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5Experimental Therapeutics and MetabolismMcGill University Health Centre-Research Institute, and Departments of Medicine, Physiology and Human Genetics, McGill University, Montreal, Quebec, CanadaToronto General Hospital200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4 Cardiovascular Endocrinology LaboratoryUniversity of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario, Canada K1Y 4W7Department of Pathology and Laboratory MedicineFaculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada K1H 8M5Experimental Therapeutics and MetabolismMcGill University Health Centre-Research Institute, and Departments of Medicine, Physiology and Human Genetics, McGill University, Montreal, Quebec, CanadaToronto General Hospital200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4
Expression of the G protein subunit Goα has been shown to be prominent in the atria of the rat heart and to be significantly associated with atrial natriuretic factor (ANF)-containing atrial-specific secretory granules by immunocytochemistry. In addition, differential expression profile analysis using oligonucleotide arrays has shown that the Goα isoform 1 (Goα1) is 2.3-fold more abundant in the atria than it is in the ventricles.
View Article and Find Full Text PDFThe heart as an endocrine organ.
Endocr Connect
April 2014
Cardiovascular Endocrinology LaboratoryUniversity of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario, Canada K1Y 4W7.
The concept of the heart as an endocrine organ arises from the observation that the atrial cardiomyocytes in the mammalian heart display a phenotype that is partly that of endocrine cells. Investigations carried out between 1971 and 1983 characterised, by virtue of its natriuretic properties, a polypeptide referred to atrial natriuretic factor (ANF). Another polypeptide isolated from brain in 1988, brain natriuretic peptide (BNP), was subsequently characterised as a second hormone produced by the mammalian heart atria.
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