1,851 results match your criteria: "Cardiomyopathy Peripartum"
Preemptive Use of a Left Microaxial Flow Pump in Peripartum Cardiomyopathy.
JACC Case Rep
December 2024
Division of Cardiology, Baylor Scott and White Health-Temple, Temple, Texas, USA.
Management of peripartum cardiomyopathy and cardiogenic shock often presents a significant clinical challenge. These patients are frequently best served at a specialized center with access to cardiac anesthesia, maternal-fetal medicine, and cardiac intensivists. Planning for delivery involves a plan for anesthesia and management of hemodynamic changes during the postoperative period.
View Article and Find Full Text PDFPeripartum cardiomyopathy in the twenty-first century: a review of the pathophysiology and clinical trials for novel disease-specific therapeutics.
Heart Fail Rev
December 2024
Cardiovascular Services Department, Queen Elizabeth Hospital, Martindales Road, Bridgetown, Barbados.
Peripartum cardiomyopathy is an idiopathic and nonischemic systolic dysfunction with onset toward the end of pregnancy and up to 5 months postpartum. Its clinical phenotype overlaps with pregnancy-associated cardiomyopathy rendering both a continuum of the same disease. Incidence varies geographically and is highest in areas where risk factors are prevalent.
View Article and Find Full Text PDFA case of peripartum cardiomyopathy in dichorionic diamniotic twin pregnancy.
Arch Clin Cases
December 2024
Department of Obstetrics and Gynaecology, Ipswich Hospital, East Suffolk and North Essex Foundation NHS Trust, Suffolk, UK.
Peripartum cardiomyopathy (PPCM) is an uncommon life-threatening condition that is characterized by heart failure with reduced ejection fraction during late pregnancy or within 5 months of postpartum in the absence of other causes of heart failure. Despite advances in managing PPCM, the pathophysiology of it is still poorly understood. This article reviews the diagnostic challenges and management of PPCM, specifically highlighting a rare presentation of PPCM characterized by oxygen desaturation alone.
View Article and Find Full Text PDFPropionic Acidemia diagnosed in Amish adults and pregnancy outcomes: A case series.
Mol Genet Metab Rep
December 2024
New Leaf Center Clinic for Special Children, 16014 East Chestnut Street Mount Eaton, OH, USA.
Article Synopsis
The triglyceride-to-high-density lipoprotein cholesterol ratio is associated with an increased risk of peripartum cardiomyopathy.
Front Endocrinol (Lausanne)
December 2024
The Key Laboratory of Cardiovascular Remodeling and Function Research, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Cheeloo College of Medicine, Qilu Hospital, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, Shandong University, Jinan, China.
Article Synopsis
- Peripartum cardiomyopathy (PPCM) is a severe heart failure condition affecting women during late pregnancy and after childbirth, with its diagnosis being complex and influenced by various factors, including abnormal lipid metabolism.
- A study involving 600 parturients found that the triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio was significantly higher in those with PPCM compared to healthy subjects, indicating a potential risk factor.
- The analysis showed that a higher TG/HDL-C ratio not only increased the risk of developing PPCM but also proved to be a reliable predictor for its onset, suggesting its importance in monitoring pregnant women.
Gene Analysis of Four Families with Severe Peripartum Cardiomyopathy Reveals Known Gene Mutations and Supports the Recent Call for Screening.
Rev Cardiovasc Med
November 2024
Department of Obstetrics & Gynecology, National Clinical Research Center for Obstetric & Gynecologic Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, 100730 Beijing, China.
Article Synopsis
- Peripartum cardiomyopathy (PPCM) is a serious condition affecting mothers that has unclear causes and varying recovery rates; genetic research may help understand it better.* -
- A study screened six patients with severe PPCM and their families, finding that 66% had pathogenic genetic mutations, with a high rate of mutation shared among family members.* -
- The research suggests that for women genetically predisposed to PPCM, pregnancy might worsen their condition, highlighting the importance of genetic counseling for those with family histories of heart disease.*
Maternal and fetal outcomes in those with autoimmune connective tissue disease.
Clin Rheumatol
November 2024
Division of Cardiology, University of Minnesota, Minneapolis, USA.
Article Synopsis
- Autoimmune connective tissue diseases (CTDs) such as systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and rheumatoid arthritis (RA) significantly impact pregnant women, leading to maternal and fetal complications.
- A retrospective study analyzed data from over 18 million deliveries and found higher odds of maternal death, acute kidney injury, and severe complications in mothers with CTDs, alongside increased risks of adverse fetal outcomes like stillbirth and preterm labor.
- The findings highlight the need for specific preconception counseling and management approaches to improve health outcomes for pregnant women with autoimmune CTDs.
CMR and adverse clinical outcomes in peripartum cardiomyopathy.
Am Heart J Plus
December 2024
University of Pittsburgh Medical Center, Pittsburgh, PA, United States of America.
Article Synopsis
- Peripartum cardiomyopathy (PPCM) poses serious health risks, and while recovery of heart function is important, it doesn't guarantee better long-term outcomes; additional assessments using cardiac MRI (CMR) can reveal further risks.
- The study analyzed 51 PPCM patients, highlighting that lower left ventricular ejection fraction (LVEF), peak global longitudinal strain (GLS), and higher extracellular volume (ECV) were linked to worse outcomes, including the need for heart assist devices or transplants.
- Findings suggest CMR might help identify patients at higher risk for serious adverse outcomes beyond what LVEF can indicate, potentially revealing future treatment targets like diffuse myocardial fibrosis.
Corrigendum: The concentration of maternal sacubitril/valsartan transferred into human milk is negligible.
Front Public Health
November 2024
Department of Obstetrics and Gynecology, School of Medicine, Texas Tech University Health Sciences Center, Amarillo, TX, United States.
Article Synopsis
- The article discusses the correction of previously published research related to public health.
- This correction addresses specific issues or errors found in the original article.
- It aims to provide accurate information and enhance the reliability of the research findings.
The risk of peripartum cardiomyopathy among pediatric, adolescent, and young adult cancer patients exposed to doxorubicin: an opinion article.
Front Oncol
November 2024
Department of Internal Medicine, University of Illinois College of Medicine Peoria, Peoria, IL, United States.
The Year in Cardiothoracic Transplant Anesthesia: Selected Highlights From 2022 Part II: Cardiac Transplantation.
J Cardiothorac Vasc Anesth
October 2024
University of Pittsburgh, Pittsburgh, PA. Electronic address:
Article Synopsis
- The highlights cover research from 2022 divided into three sections: preoperative, intraoperative, and postoperative, focusing on advancements in heart transplantation.
- The preoperative section discusses candidate assessment, donor optimization, and factors like cannabis use and comorbidities that impact transplantation success.
- The intraoperative section emphasizes teamwork and surgical techniques while the postoperative section highlights managing complications like tricuspid regurgitation and exploring xenotransplantation options.
Strategies to Improve Clinical Outcomes of Women with Cardiogenic Shock.
Interv Cardiol Clin
January 2025
Department of Cardiology, Northside Cardiovascular Institute, Lawrenceville, GA 30046, USA.
Article Synopsis
Dilated Cardiomyopathy: A Genetic Journey from Past to Future.
Int J Mol Sci
October 2024
Division of Cardiology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Article Synopsis
- Dilated cardiomyopathy (DCM) is a heart condition marked by reduced function and enlargement of the heart, with idiopathic cases (IDC) showing a link to genetic factors in 40% of instances.
- Over 200 genes have been connected to DCM, but evidence to confirm their roles is still limited; recent advancements in genetic research reveal a mix of genetic influences, ranging from single-gene to multiple-gene interactions.
- Current recommendations for DCM include genetic counseling and testing, along with some targeted treatments, while future developments in the field may focus on polygenic risk scores and more personalized medicine approaches.
Myocardial Posttranscriptional Landscape in Peripartum Cardiomyopathy.
Circ Heart Fail
December 2024
School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, NSW, Australia (A.L., B.F., Y.C.K., C.M., B.H., D.H., C.G.d.R., M. Larance, J.F.O., S.L.).
Article Synopsis
- Pregnancy causes significant changes in a woman’s heart and vascular system, but some women can develop a heart condition called peripartum cardiomyopathy (PPCM) during or after pregnancy which can lead to heart failure.
- A study used mass spectrometry to compare protein and metabolite profiles from heart tissue of patients with end-stage PPCM against those with dilated cardiomyopathy (DCM) and non-failing heart donors, aiming to understand the molecular differences.
- Findings revealed two specific proteins (SBSPON and TNS3) were downregulated in PPCM, disrupting tissue remodeling, while certain metabolites showed abnormal levels indicating altered metabolic functions; both PPCM and DCM shared some inflammatory pathways but differed significantly in thyroid
Subsequent pregnancies in peripartum cardiomyopathy: Patient-level differences and decision-making.
Am Heart J Plus
November 2024
Pregnancy and Perinatal Research Center, Department of Obstetrics and Gynecology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States of America.
Article Synopsis
CardioMEMS as an aid to the management of a pregnant patient with peripartum Cardiomyopathy: A case report.
Eur J Obstet Gynecol Reprod Biol
December 2024
Division of Cardiology, Zucker School of Medicine at Hofstra/Northwell, Manhasset, NY, United States.
Article Synopsis
- * The CardioMEMS device provided real-time data on her heart health, enabling healthcare providers to make timely adjustments to her treatment plan, which helped maintain her stability during pregnancy.
- * The report emphasizes the advantages of using the CardioMEMS system in high-risk pregnancies, showcasing that the patient avoided hospital admissions and successfully delivered a healthy baby vaginally.
Outcomes of peripartum cardiomyopathy in North Africa: insights from a single-center observational study in Tunisia.
BMC Pregnancy Childbirth
November 2024
Department of Gynecology and Obstetrics, Faculty of Medicine, Hedi Chaker University Hospital, University of Sfax, Sfax, Tunisia.
Article Synopsis
- - Peripartum cardiomyopathy (PPCM) is a rare and serious heart condition often occurring during or after pregnancy; this study assessed its outcomes in North Africa over a 12-year period from 2010 to 2022.
- - Out of 27 PPCM patients studied, most presented symptoms like severe dyspnea and had a low average heart function measurement (LVEF of 30%); complications included pulmonary edema (85%) and the need for ECMO support in two patients.
- - The follow-up revealed that 67% of patients showed recovery in heart function, but the overall mortality rate was 15%, with significant mortality associated with factors like past pregnancies and poor prenatal care.
Pharmacological interventions for peripartum cardiomyopathy.
Cochrane Database Syst Rev
October 2024
Assisted Reproduction Unit, 2nd Department of Obstetrics and Gynaecology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Article Synopsis
- The protocol outlines a Cochrane Review focused on interventions for women with Peripartum Cardiomyopathy (PPCM).
- The main goal is to evaluate how effective and safe various medications are for treating this condition.
- This review aims to provide reliable evidence to guide healthcare decisions regarding pharmacological options for these patients.
Breastfeeding in patients with peripartum cardiomyopathy: clinical outcomes and physician counseling.
Int Breastfeed J
October 2024
Department of Medicine, Division of Cardiovascular Medicine, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA.
Article Synopsis
- Peripartum cardiomyopathy (PPCM) is heart failure occurring during late pregnancy or after delivery, leading to debates about the effects of breastfeeding on recovery.
- A study analyzed 220 women diagnosed with PPCM, focusing on their lactation status and rates of heart recovery, finding no significant differences between those who breastfed and those who did not.
- Most women reported receiving discouragement against breastfeeding due to their heart condition, highlighting a gap in supportive counseling regarding lactation options.
Article Synopsis
- - The study investigates peripartum cardiomyopathy (PPCM) mortality rates from 1999 to 2020 and how they relate to social vulnerability as measured by the Social Vulnerability Index (SVI), finding significant disparities based on demographics and geographical locations.
- - Researchers analyzed mortality data and SVI rankings across U.S. counties, revealing that Black populations and residents in the Southern U.S. experienced the highest age-adjusted mortality rates (AAMRs), with higher SVI linked to increased excess deaths.
- - The findings highlight that higher social vulnerability is associated with increased PPCM mortality, indicating that both racial background and geographic location contribute to health disparities in the U.S.
What Do We Know about Peripartum Cardiomyopathy? Yesterday, Today, Tomorrow.
Int J Mol Sci
September 2024
Department of Cardiology, University Clinical Center of Serbia, 11000 Belgrade, Serbia.
Article Synopsis
- * The exact cause of peripartum cardiomyopathy is unclear, although factors like age, lifestyle, and genetics may play a role; recent theories suggest that an abnormal form of prolactin may contribute to the heart damage.
- * Ongoing research explores treatments like bromocriptine, a drug that inhibits prolactin, and highlights the importance of safe medication use during pregnancy and breastfeeding, particularly to protect both mothers and their babies.
Baseline Characteristics and Clinical Insights from the ARTEMIS Registry: A Comprehensive Study of Peripartum Cardiomyopathy in Türkiye.
Turk Kardiyol Dern Ars
October 2024
Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Türkiye.
Article Synopsis
- The ARTEMIS registry investigates Peripartum Cardiomyopathy (PPCM), a serious condition occurring during late pregnancy or shortly after childbirth, focusing on clinical characteristics and outcomes in Turkish patients.
- The study observed 293 women primarily aged 25-35 diagnosed with PPCM, mostly presenting symptoms like shortness of breath, and found a low usage of advanced imaging techniques, relying mainly on echocardiography.
- Results indicated a 5.1% mortality rate among patients, emphasizing the need for better education for healthcare practitioners and the critical role of national registries in managing rare diseases like PPCM.
A practical approach to the diagnosis and initial management of acute right ventricular failure during pregnancy using point-of-care ultrasound.
Am J Obstet Gynecol MFM
December 2024
Department of Obstetrics and Gynecology and Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX (Pacheco).
Article Synopsis
- - Acute right ventricular failure (ARVF) in pregnancy poses serious risks to both mother and baby, necessitating quick and effective diagnosis and management, particularly through Point-of-Care Ultrasound (POCUS).
- - POCUS allows real-time assessment of the right ventricle and fluid status, aiding in the detection of conditions like pulmonary embolism and helping tailor immediate treatment strategies to manage ARVF in pregnant patients.
- - While POCUS offers significant benefits in emergency situations, effective use requires specialized training and integration into standard obstetric care protocols for optimal outcomes.
Peripartum cardiomyopathy: a comprehensive and contemporary review.
Heart Fail Rev
November 2024
Division of Cardiology, Department of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 2193, South Africa.
Article Synopsis
- * Peripartum cardiomyopathy is a specific type of heart failure that occurs in late pregnancy or after childbirth, and diagnosing it can be difficult, leading to serious health risks for mothers.
- * Recent advancements in research focus on better understanding and managing peripartum cardiomyopathy through biomarkers, genetics, targeted treatments, multidisciplinary care, and enhanced patient education.
Mechanical circulatory support for cardiogenic shock during the peripartum period.
Artif Organs
September 2024
Division of Cardiology, Department of Medicine, Columbia University College of Physicians and Surgeons and NewYork-Presbyterian Hospital, New York, New York, USA.
Article Synopsis
- Cardiomyopathies are a significant cause of cardiovascular issues in the peripartum period, and the study focuses on cases of cardiogenic shock (CS) requiring mechanical circulatory support (MCS).
- The retrospective analysis included 11 cases, with a majority of patients experiencing shock after delivery and many treated with various MCS devices like intra-aortic balloon pumps and ECMO.
- Outcomes showed a high recovery rate of 63.6% over a median follow-up of 4.5 years, suggesting that MCS could be a viable option before considering heart transplants.