270 results match your criteria: "Cardiomyopathy Cocaine"
Characteristic Cardiac Magnetic Resonance (CMR) Imaging Findings of Cocaine-Induced Myocardial Injury.
Cureus
August 2024
Cardiology, Baylor Scott & White Medical Center - Temple, Temple, USA.
Article Synopsis
- - Cocaine use can lead to serious heart conditions such as heart attacks and cardiomyopathy, posing significant health risks and burdens on healthcare systems.
- - Cardiac magnetic resonance (CMR) imaging is essential for identifying and assessing heart damage, allowing for the differentiation between acute and chronic injuries linked to cocaine use.
- - Early detection through CMR can help reverse damage caused by cocaine, making it a crucial tool for better management of cocaine-related heart issues.
Characteristics and in-hospital outcomes of female patients presenting with ST-segment-elevation myocardial infarction without standard modifiable cardiovascular risk factors.
Curr Probl Cardiol
December 2024
Department of Medicine, Stern Cardiovascular Foundation, Germantown, TN, USA.
Article Synopsis
- Standard Modifiable Cardiovascular Risk Factors (SMuRF), like hypertension and diabetes, are typically significant in causing atherosclerotic disease, but this study looks at female STEMI patients who lack those risk factors.
- Researchers analyzed data from over 200,000 STEMI admissions, finding that only 6.6% of patients were without any SMuRF, and these patients were generally older and more likely to be white.
- Interestingly, SMuRF-less patients had a higher in-hospital mortality rate (three times more likely) than those with SMuRF, even though they had fewer other heart-related conditions, highlighting the unique challenges in this group.
Cigar-shaped left ventricular thrombus in cocaine-related cardiomyopathy: echocardiography, cardiac MRI and coronary CT angiography correlations.
Eur Heart J Cardiovasc Imaging
November 2024
Department of Imaging and Medicine, Cedars-Sinai Medical Center, 8700 Beverly Blvd. Los Angeles, CA 90048, USA.
Cardiovascular and pulmonary complications of recreational drugs: A pictorial review.
Eur J Radiol
September 2024
Radiology Department, Liverpool Heart and Chest Hospital, Thomas Drive, Liverpool L14 3PE, United Kingdom; Cardiovascular Research Center-ICCC, IIB-Sant Pau, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. Electronic address:
Article Synopsis
- Recreational drug abuse is a major global health issue that leads to serious heart and lung problems, with both immediate and long-term effects.
- Common cardiovascular issues include heart attacks, infections, and high blood pressure in the lungs, while pulmonary complications can include fluid buildup, pneumonia, and lung damage.
- This article plans to visually showcase the various heart and lung problems associated with drug use, highlighting the underlying causes and how they appear in medical imaging.
Substance Use in Pregnancy and its Association With Cardiovascular Events.
JACC Adv
October 2023
Barbra Streisand Women's Heart Center, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Article Synopsis
- Substance use during pregnancy is on the rise in the U.S., yet its relationship with cardiovascular (CV) events in pregnant women had not been thoroughly explored until this study.
- An analysis of over 60 million delivery hospitalizations from 2004 to 2018 revealed a significant link between substance use and increased risks of acute CV events, major adverse cardiac events, and maternal mortality.
- Specifically, amphetamine/methamphetamine showed the highest association with CV events, highlighting the need for heightened monitoring of women using substances during their hospitalizations for delivery.
Cocaine and amphetamine-regulated transcript improves myocardial ischemia-reperfusion injury through PI3K/AKT signalling pathway.
Clin Exp Pharmacol Physiol
August 2024
Department of Molecular Pharmacology, School of Medicine, Nankai University, Tianjin, China.
Article Synopsis
- * Research revealed that CART helps protect the heart during ischemia-reperfusion by reducing cell death (apoptosis) and excessive autophagy, suggesting it could be a promising treatment for MIRI.
- * CART functions by activating the phospho-AKT pathway, which decreases harmful effects like lactate dehydrogenase release and oxidative stress, but this protective effect is blocked by a PI3K inhibitor, indicating the significance of the PI3K/AKT signaling pathway in
Article Synopsis
- A case involving a 33-year-old male with serious mental health issues and heart failure reveals the significance of identifying TTN gene mutations in cases of unexplained cardiomyopathy, particularly when there’s a family history.
- * Genetic counseling and testing are recommended for family members at risk, stressing the importance of personalized healthcare management that considers genetics and lifestyle choices.
- * This case underlines the need for comprehensive genetic analysis to improve diagnosis and treatment of dilated cardiomyopathy (DCM), illustrating the link between genetic predisposition and environmental factors.
Left Ventricular Non-compaction and Associated Cardiomyopathy Presenting With Cardiac Failure: A Case Report.
Cureus
April 2024
Internal Medicine, Adesh Institute of Medical Science and Research, Bathinda, IND.
Article Synopsis
- Left ventricular non-compaction (LVNC) is characterized by a thick trabecular meshwork in the heart and can lead to various complications, from mild to severe cardiac issues.
- Despite increasing awareness, the prevalence and clinical spectrum of LVNC in adults are still not well understood, leading to challenges in patient management.
- A case study highlights an adult patient with congestive heart failure diagnosed with LVNC, underscoring the need for improved diagnostic criteria that incorporate genetic, clinical, and imaging information.
Rapid Recovery From Cocaine-Induced Cardiomyopathy: A Case Report.
Cureus
December 2023
Cardiology, Steward Carney Hospital, Dorchester, USA.
Article Synopsis
- - A 33-year-old man experienced shortness of breath and confusion, prompting a medical evaluation.
- - Toxicology tests revealed the presence of cocaine and fentanyl in his system, raising concerns about his heart health.
- - An echocardiogram showed severe heart dysfunction, but his condition significantly improved just four days after the diagnosis of cocaine-induced cardiomyopathy.
Implementing Heart Plus: Design and Early Results of a Novel Comanagement Clinic for Patients With Stimulant-associated Cardiomyopathy.
J Card Fail
July 2024
Division of General Internal Medicine, Zuckerberg San Francisco General Hospital, University of California, San Francisco, San Francisco, California.
Article Synopsis
- This text outlines a new clinic model called Heart Plus that combines Addiction Medicine and Cardiology to treat patients with stimulant-associated cardiomyopathy (SA-CMP).
- The approach uses contingency management to significantly improve outpatient care engagement and reduce emergency visits and hospital admissions among these patients.
- Participants experienced a decrease in stimulant use and were better positioned to access social support services, leading to improved overall health and well-being.
Evaluation of the cardiovascular risk induced by cannabis use from a series of 43 autopsy cases.
Int J Legal Med
November 2023
Service de Pharmacologie-Toxicologie, Hôpital Raymond Poincaré, Groupe Hospitalier Universitaires AP-HP.Paris-Saclay, 92380, Garches, France.
Article Synopsis
- This autopsy study analyzed 43 cases of individuals who had THC in their blood to investigate the link between cannabis use and cardiovascular risk over two years.
- Researchers performed toxicological and hair analyses to categorize cannabis use and assess other drug exposures.
- The study found significant associations between cannabis use and serious heart conditions, implying that cannabis might contribute to sudden deaths related to cardiac issues, often classified as accidents.
The Impact of Cocaine Use and the Obesity Paradox in Patients With Heart Failure With Reduced Ejection Fraction Due to Non-ischemic Cardiomyopathy.
Cureus
June 2023
Department of Medicine, New York Medical College, Metropolitan Hospital Center, New York, USA.
Article Synopsis
- Obesity and illicit drug use, like cocaine, are known risk factors for heart failure (HF), but recent studies suggest that obese patients with HF may have better outcomes compared to non-obese patients.
- This study analyzed data from heart failure patients at Metropolitan Hospital in New York, focusing on the impact of body mass index (BMI) and cocaine use on hospital readmissions within 30 days.
- Findings revealed that non-obese patients using cocaine had a significantly higher risk of readmission within 30 days, indicating that both non-obesity and cocaine use negatively influence HF outcomes.
Unusual Presentation and Outcome in Acute Cocaine Intoxication With Multiorgan Failure: A Case Report.
Cureus
May 2023
Internal Medicine, Michigan State University, East Lansing, USA.
Article Synopsis
- * This report details a unique case of a patient who suffered cardiac arrest and unusual symptoms due to high-dose cocaine use.
- * The patient experienced a remarkable recovery, highlighting important insights into the prognosis of severe complications from cocaine toxicity.
Prevalence of illicit drug use in young patients with sudden cardiac death.
Heart Rhythm
October 2023
Department of Cardiology, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia; Department of Cardiology, Alfred Hospital, Prahran, Victoria, Australia; Baker Heart and Diabetes Institute, Prahran, Victoria, Australia; Department of Medicine, Dentistry and Health Sciences, Melbourne University, Parkville, Victoria, Australia. Electronic address:
Article Synopsis
- The study aimed to find out the prevalence of illicit drug use among young patients (ages 18-50) who experienced sudden cardiac death (SCD) between April 2019 and April 2021.
- Results showed that 32.5% of the 554 patients had either positive toxicology for illicit drugs or reported regular use, with cannabis being the most common drug found.
- Young SCD patients using illicit drugs tended to be predominantly male, more likely to be smokers and heavy drinkers, and often had psychiatric diagnoses, but did not show significant differences in rates of coronary disease or cardiomyopathy compared to non-users.
Cardiac Arrest (CA) as the Initial Presentation of Cocaine-Induced Takotsubo Cardiomyopathy (TCM): A Case Report and Review of Literature.
Cureus
May 2023
Internal Medicine, Brookdale University Hospital Medical Center, Brooklyn, USA.
Article Synopsis
- * The use of cocaine can lead to various heart problems, including coronary artery spasms and congestive heart failure, as well as a rare condition called Takotsubo cardiomyopathy (TCM), which affects heart muscle movement without any blockage in the coronary arteries.
- * A case report details a 54-year-old man who suffered a cardiac arrest linked to cocaine use and was diagnosed with TCM, highlighting the importance for doctors to recognize this connection, as stopping cocaine can lead to full recovery from TCM.
Catecholamine Mega Storm Triggered by Cocaine Use and Thyrotoxicosis Crisis.
Cureus
April 2023
Internal Medicine, Albany Medical Center, Albany, USA.
Article Synopsis
- - Takotsubo cardiomyopathy (TCM) is a heart condition triggered by extreme physical or emotional stress, linked to factors like thyroid storm and cocaine use.
- - A case study describes a 26-year-old male with Graves' disease and cocaine issues, who experienced TCM and cardiogenic shock due to a thyroid storm.
- - The patient underwent intensive treatment, including extracorporeal membrane oxygenation, and successfully recovered his heart function after receiving antithyroid medications and steroids.
A Novel Nonsense Pathogenic Variant Identified in a Patient with Severe Dilated Cardiomyopathy.
Curr Issues Mol Biol
March 2023
Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, Sapienza University of Rome, 00189 Rome, Italy.
Article Synopsis
- Genetic and environmental factors both play a role in a heart disease called dilated cardiomyopathy (DCM).
- A 57-year-old woman with severe DCM had a family history of the disease and other health issues like high blood pressure and smoking.
- Genetic testing found a new mutation in a protein important for heart structure, showing that family history can be important for understanding DCM even if there are other risk factors.
Spiked Helmet Electrocardiographic Sign-A Systematic Review of Case Reports.
Curr Probl Cardiol
March 2023
Division of Cardiology, Kingston Health Science Center, Queen's University, Kingston, Ontario, Canada.
Article Synopsis
- The spiked helmet sign (SHS), an ECG pattern associated with poor outcomes, was first identified in 2011, prompting a study to evaluate its characteristics and clinical outcomes based on existing literature.
- A total of 39 patients from 26 case reports were examined, finding that the most common associated conditions included intracranial hemorrhages and pneumothorax, with many patients facing multiple complications.
- Of the 32 patients whose outcomes were reported, 59% died during hospitalization, emphasizing the need for clinicians to quickly recognize SHS and assess for underlying issues, alongside calls for more extensive research on its prevalence and implications.
Hypertension in the Setting of Hypertrophic Obstructive Cardiomyopathy and Cocaine Use.
Cureus
October 2022
Cardiology, Icahn School of Medicine at Mount Sinai, Queens Hospital Center, New York, USA.
Article Synopsis
- Hypertrophic obstructive cardiomyopathy (HOCM) is a genetic condition that complicates the treatment of hypertension, as many medications are unsuitable for these patients.
- Beta blockers are favored for managing hypertension in HOCM; however, the use of these medications in patients who use cocaine can worsen hypertension due to the interaction between the drugs.
- Non-dihydropyridine calcium channel blockers are another option but may not counteract the effects of cocaine, highlighting the importance of educating HOCM patients to avoid cocaine use.
Takotsubo Cardiomyopathy After Cocaine Intoxication.
Eur J Case Rep Intern Med
September 2022
Department of Cardiology, Saint Michael's Medical Center, Newark, New Jersey, USA.
Article Synopsis
- Cocaine is a highly addictive drug that can lead to serious cardiovascular issues, including a rare condition called Takotsubo cardiomyopathy, which can occur even in healthy individuals without other risk factors.
- A case study presented involved a female who developed Takotsubo cardiomyopathy after using cocaine, emphasizing the need for awareness among healthcare providers.
- Prompt diagnosis and treatment are crucial for improving outcomes, and doctors should be vigilant in considering cocaine use as a factor in cardiovascular conditions.
Apical Hypertrophic Cardiomyopathy Prompting Aneurysm, Thrombus, and Cardiac Arrest in a 56-Year-Old Female.
Cureus
June 2022
Cardiology, Lincoln Medical Center, New York City, USA.
Article Synopsis
- * This case report details a 56-year-old woman with apHCM who experienced severe chest pain, ventricular tachycardia, and cardiac arrest, initially linked to recent cocaine use; however, further imaging revealed significant heart complications.
- * The patient's recovery involved stabilization and treatment with medications like amiodarone and beta-blockers, along with the implantation of a defibrillator, highlighting the importance of recognizing and properly managing apHCM to prevent critical outcomes. *
Profound Vagal Tone and Bradycardia Mimicking Asystole: A Resuscitation Case Report.
Case Rep Cardiol
March 2022
Cardiology Department, Tipperary University Hospital, Clonmel, Tipperary, Ireland.
Article Synopsis
- * He had a history of a heart issue due to cocaine use, which led to ischaemic cardiomyopathy, resulting in a reduced heart function (LVEF of 45%).
- * Following an hour of dangerous heart rhythms and asystole, he regained consciousness after receiving atropine for extreme bradycardia, likely caused by increased vagal tone.
Heavy Burden of Toxic Dilated Cardiomyopathy Among Young Adults: A Retrospective Study and Review of the Literature.
Can J Cardiol
January 2022
Institut Universitaire de Cardiologie et de Pneumologie de Québec, Laval University, Québec City, Québec, Canada. Electronic address:
Article Synopsis
- Dilated cardiomyopathy (DCM) is a significant cause of heart failure in younger patients, with recent findings identifying toxic cardiomyopathy (TCM) from substance abuse as a notable trigger.
- A study of 553 patients revealed that 19% had TCM, commonly linked to substances like amphetamines and cocaine, with a majority achieving event-free survival and some recovering heart function with proper treatment.
- Mechanical support, such as left ventricular assist devices (LVADs), was beneficial for select patients, highlighting the need for personalized treatment approaches.
Cardiac Complications of Common Drugs of Abuse: Pharmacology, Toxicology, and Management.
Can J Cardiol
September 2022
Department of Medicine and Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada. Electronic address:
Article Synopsis
- Cardiovascular issues linked to substance abuse are on the rise, especially among young adults, leading to serious conditions like acute coronary syndrome and arrhythmias.
- There are no specific screening guidelines for these complications, so it's crucial for healthcare providers to recognize, diagnose, and treat these heart-related issues while also addressing mental health.
- A significant number of young adults misuse multiple substances, increasing their risk for heart disease and long-term health problems; this review focuses on the heart risks associated with common drugs like cocaine and alcohol.
Changing Incidence and Mechanism of Pregnancy-Associated Myocardial Infarction in the State of California.
J Am Heart Assoc
November 2021
Article Synopsis
- * Among the 341 identified PAMI cases, there was a 7% maternal mortality rate and a 3.5% infant mortality rate, with older age, Black race, lower income, and various health conditions being significant risk factors.
- * The findings suggest a potential rise in PAMI incidence linked to conditions like spontaneous coronary artery dissection and warrant further research to understand underlying mechanisms.