1,934 results match your criteria: "Cardiomyopathy Alcoholic"
Identification of Pre-Heart Failure in Early Stages: The Role of Six Stages of Heart Failure.
Diagnostics (Basel)
November 2024
Department of Gediatrics, PJ Safaric University, 04001 Kosice, Slovakia.
Despite increased availability of effective drug therapy for treatment of heart failure (HF), the morbidity and mortality in chronic heart failure (CHF) are unacceptably high. Therefore, there is an urgent need to ascertain new imaging techniques to identify early sub-clinical forms of cardiac dysfunctions, to guide early relevant treatment. It seems that all the behavioral risk factors-such as tobacco, alcoholism, Western-type diet, sedentary behavior and obesity, emotional disorders, and sleep disorder are associated with early cardiac dysfunction, which may be identified by speckle-tracking echocardiography (STE).
View Article and Find Full Text PDFINFLUENCE OF VITAMIN E ON PANCREATIC ACINAR CELL MORPHOLOGY AND SERUM AMYLASE CONCENTRATIONS IN ALCOHOL-INDUCED PANCREATIC TOXICITY.
J Ayub Med Coll Abbottabad
December 2024
Department of Physiology.
Background: Misusing alcohol can cause damage to different tissues in the body, resulting in conditions like alcoholic liver disease, pancreatitis, cardiomyopathy, neurotoxicity, muscle wasting, weakened immune system, hormonal disruptions, birth defects, and bone loss. The objective of this research was to evaluate how alcohol affects the exocrine pancreas histology and the levels of amylase in the blood serum. Additionally, it aimed to explore whether vitamin E provides a safeguard against alcohol-induced harm to the pancreas in rabbits.
View Article and Find Full Text PDFNon-alcoholic fatty liver disease and LV diastolic dysfunction in patients with type 2 diabetes mellitus.
Caspian J Intern Med
October 2024
Department of Internal Medicine, School of Medicine, Imam Khomeini Hospital, Urmia University of Medical Sciences, Urmia, Iran.
Article Synopsis
- - This study investigates the link between non-alcoholic fatty liver disease (NAFLD) and early left ventricular diastolic dysfunction (LVDD) in patients with type 2 diabetes mellitus (T2DM).
- - Conducted on ninety diabetic outpatients, the study did not find a significant association between NAFLD and LVDD progression, despite high rates of both conditions among participants.
- - The research highlights the importance of monitoring LVDD in diabetic patients with NAFLD to potentially prevent future heart complications, even without a direct correlation found between the two conditions.
Comprehensive Health Assessment Using Risk Prediction for Multiple Diseases Based on Health Checkup Data.
AJPM Focus
December 2024
NEC Solution Innovators, Ltd., Tokyo, Japan.
Article Synopsis
- The study aimed to create risk prediction models that estimate the likelihood of multiple diseases (heart, brain, liver, etc.) using only health checkup data for personalized healthcare strategies.
- Researchers analyzed health checkup data from over 92,000 individuals and developed models using Cox proportional hazard regression to predict disease risk based on various health metrics.
- The developed models showed strong predictive capabilities, with high area under the curve scores for several diseases, potentially aiding in early diagnosis and targeted prevention strategies.
Beneficial effect of linn., on diabetic cognitive dysfunction and cardiac complications in streptozotocin-induced diabetic rats.
Heliyon
November 2024
Department of Pharmacology, College of Pharmacy, Al-Dawadmi, Shaqra University, Ministry of Higher Education, Kingdom of Saudi Arabia.
Article Synopsis
- The study explores the use of a standardized alcoholic extract of seeds (CPS) from an Indian traditional medicinal plant for treating diabetes-related complications, including neuropathy and cardiac issues in rodents.
- The research involved administering two doses of CPS to diabetic rats and monitoring their effects on blood glucose levels, body weight, and various health parameters over six weeks, alongside histopathological examinations.
- Results indicated that CPS treatment significantly improved motor functions, reduced diabetic complications, and normalized blood pressure and other vital signs, suggesting its potential as a therapeutic agent for diabetes management.
Role of cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes pathway in diabetes and its complications.
World J Diabetes
October 2024
Department of Gastroenterology, Binzhou Medical University Hospital, Binzhou 256600, Shandong Province, China.
Article Synopsis
- - Diabetes mellitus (DM) is a major global health issue, heavily influenced by inflammation, and the review focuses on the cGAS-STING pathway that plays a key role in these inflammatory responses.
- - The study discusses the involvement of the cGAS-STING pathway in various complications of DM, including early-stage DM, diabetic gastroenteropathy, diabetic cardiomyopathy, and non-alcoholic fatty liver disease.
- - It also explores the potential of targeting the cGAS-STING pathway for developing therapeutic agents aimed at improving precision treatment for diabetes and its related complications.
Long-Term Outcomes in ICD: All-Causes Mortality and First Appropriate Intervention in Ischemic and Nonischemic Etiologies.
Am J Cardiol
December 2024
Cardiovascular Department, Azienda Sanitaria Universitaria Giuliano-Isontina (ASUGI), University of Trieste, Trieste, Italy.
Article Synopsis
- A study analyzed long-term outcomes in 1,184 patients with implantable cardioverter defibrillators (ICDs) to compare the risks of appropriate interventions and overall survival between those with ischemic heart disease (IHD) and non-ischemic heart disease (NIHD).
- Findings revealed that all-cause mortality was significantly higher in patients with IHD (60%) compared to those with NIHD (43%), but the rate of appropriate ICD interventions did not differ significantly over ten years (34% for IHD vs. 40% for NIHD).
- Additionally, within NIHD, certain types of heart disease like valvular disease and chemotherapy-related dilated cardiomyopathy showed higher mortality rates, while inappropriate
Heightened TPD52 linked to metabolic dysfunction and associated abnormalities in zebrafish.
Arch Biochem Biophys
November 2024
Institute of Biopharmaceutical Sciences, National Yang Ming Chiao Tung University, Taipei, 112, Taiwan. Electronic address:
Article Synopsis
- - The TPD52 gene, linked to breast and prostate cancers, impacts biological processes like cell growth and lipid metabolism, but its exact role in animals is unclear.
- - Researchers created Tpd52 transgenic zebrafish to study its effects on fat production, finding that higher TPD52 levels led to increased weight and enlarged fat deposits due to enlarged fat cells.
- - The study showed that TPD52 promotes pathologies such as visceral obesity and nonalcoholic fatty liver disease by activating specific signaling pathways, highlighting its significant role in fat tissue growth and associated health issues.
Insulin Resistance, Obesity, and Lipotoxicity.
Adv Exp Med Biol
September 2024
Koç University Medical School, Section of Endocrinology and Metabolism, Koç University Hospital, Topkapi, Istanbul, Turkey.
Article Synopsis
Burden of alcohol use disorder and its consequences in Iran from 1990 to 2019: Findings from the global burden of disease study.
Prev Med Rep
October 2024
Sports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Article Synopsis
- - The study evaluated the impact of alcohol use disorder and its related health issues in Iran from 1990 to 2019, using Global Burden of Disease (GBD) data to analyze various health metrics.
- - Notably, there was a significant decline in age-standardized Disability-Adjusted Life Years (DALY) for alcohol use disorder and its complications like cirrhosis and liver cancer, indicating some progress in reducing the health burden.
- - However, alcohol use disorder still presents a serious public health issue in Iran, particularly affecting younger individuals, while cirrhosis greatly impacts the older population.
Exploring the etiology of dilated cardiomyopathy using Mendelian randomization.
Front Cardiovasc Med
August 2024
Department of Cardiology, The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Article Synopsis
- Observational studies suggest several factors may be linked to dilated cardiomyopathy (DCM), including genetic markers and conditions like hyperthyroidism and alcoholism, but the causality of these links remains unclear.
- *The study aims to investigate the causes of DCM using a method called Mendelian randomization, which analyzes genetic data to draw conclusions about risk factors.
- *Results show that titin protein may protect against DCM, while cardiac troponin I and desmocollin-2 are associated with an increased risk, but no causal relationships were found with other potential factors.
Left Ventricular Assist Device as a Bridge-to-Recovery Strategy in Alcoholic Cardiomyopathy: A Case Series.
Can J Cardiol
August 2024
Université de Lorraine, INSERM 1433, Centre d'Investigations Cliniques Plurithématique, CHRU de Nancy, France; INI-CRCT, F-CRIN Network, Nancy, France; REICATRA, Université de Lorraine, Vandœuvre-lès-Nancy, France. Electronic address:
Additive effect of metabolic dysfunction-associated fatty liver disease on left ventricular function and global strain in type 2 diabetes mellitus patients: a 3.0 T cardiac magnetic resonance feature tracking study.
Cardiovasc Diabetol
August 2024
Department of Radiology, West China Hospital, Sichuan University, 37# Guo Xue Xiang, Chengdu, 610041, Sichuan, China.
Article Synopsis
- Type 2 diabetes mellitus (T2DM) and metabolic-associated fatty liver disease (MAFLD) are linked metabolic disorders that adversely affect heart function, and the study examined the combined impact of MAFLD on heart health in T2DM patients using cardiac magnetic resonance imaging.
- The research analyzed data from 261 T2DM patients—109 with MAFLD and 152 without—compared to 73 healthy controls, assessing various heart function parameters and using statistical methods to evaluate the effects of different factors.
- Results indicated that heart function deteriorates progressively with the presence of MAFLD, as evidenced by significant changes in heart volume and strain measurements, establishing MAFLD as a notable predictor of heart health decline in
[Forensic toxicological characteristics of modern occupational injuries].
Sud Med Ekspert
August 2024
Bureau of Forensic Medical Expertise of Moscow Healthcare Department, Moscow, Russia.
Article Synopsis
- - The study focused on analyzing the role of alcohol and drug intoxication in fatal workplace injuries and sudden deaths among employees in Moscow, investigating 357 cases in 2023 with an average age of around 48 years, predominantly involving men (92.4%).
- - It was found that 15% of the deceased had ethanol in their blood, while 6.7% had narcotic drugs or psychotropic medications, with chronic intoxication playing a significant role in 70% of cardiomyopathy cases.
- - The research highlights the need for measures to reduce occupational mortality related to substance use, noting that nearly 24% of accidents occurred in industrial or construction settings influenced by alcohol.
Navigating complex cardiac complications: A case report of alcoholic cardiomyopathy and right atrial thrombosis.
Medicine (Baltimore)
August 2024
Faculty of Medicine, Aleppo University, Aleppo, Syrian Arab Republic.
Article Synopsis
- - The case discusses a 53-year-old man with alcoholic cardiomyopathy (ACM) who presented symptoms like shortness of breath and abdominal swelling, leading to a diagnosis of ACM, liver cirrhosis, and a rare isolated right atrial (RA) thrombus.
- - Initial tests missed the RA mass, but advanced imaging techniques ultimately identified a large thrombus measuring 40x22x18 mm, prompting treatment with medication and a procedure called mechanical thrombectomy.
- - The case highlights that isolated RA thrombosis is a rare complication of ACM, emphasizing the importance of using multiple imaging methods, especially transesophageal echocardiography, for accurate diagnosis and management in such cardiac cases.
Non-alcoholic fatty liver disease and heart failure: A comprehensive bioinformatics and Mendelian randomization analysis.
ESC Heart Fail
December 2024
Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, China.
Article Synopsis
Phosphoglycerate mutase 5 exacerbates alcoholic cardiomyopathy in male mice by inducing prohibitin-2 dephosphorylation and impairing mitochondrial quality control.
Clin Transl Med
August 2024
Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Article Synopsis
Detrimental Effects of Alcohol on the Heart: Hypertension and Cardiomyopathy.
Rev Cardiovasc Med
October 2023
Department of Cardiology, St Mary Medical Center, Langhorne, PA 19047, USA.
Article Synopsis
A Chinese patient with Madelung's disease and alcoholic cardiomyopathy: a case report and literature review.
Eur Rev Med Pharmacol Sci
July 2024
Department of Endocrinology, Qingdao Municipal Hospital, Qingdao, China.
Article Synopsis
- Madelung's disease is a rare condition that causes significant fat accumulation in the upper body, mostly affecting middle-aged alcoholic men from Mediterranean regions, while being less common in Asian populations.
- A case study highlighted a 67-year-old man with Madelung's disease who experienced severe heart dysfunction linked to alcoholism, demonstrating issues like elevated liver enzymes and heart enlargement.
- The study emphasizes the importance of recognizing alcohol use disorder in Madelung's patients and suggests that screening for heart issues is crucial for better outcomes.
Protective Effect of Deer Heart Peptide on Cardiac Injury in Mice.
Int J Inflam
May 2024
School of Life Sciences, Changchun Sci-Tech University, Changchun 130600, Jilin, China.
Article Synopsis
Embryonic alcohol exposure in zebrafish predisposes adults to cardiomyopathy and diastolic dysfunction.
Cardiovasc Res
November 2024
Division of Basic and Translational Cardiovascular Research, Department of Cardiology, Boston Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
Article Synopsis
- The study examines the long-term effects of embryonic alcohol exposure (EAE) on heart health in adult zebrafish, finding that it leads to structural and functional heart issues.
- Researchers used advanced techniques like echocardiography and RNA-sequencing to identify changes in heart function and gene expression associated with cardiomyopathy and diastolic dysfunction.
- The findings highlight that EAE increases the risk of cardiovascular problems in adulthood and identifies potential genetic markers that could be linked to these heart conditions.
A Comprehensive Review on Alcohol Abuse Disorder Fatality, from Alcohol Binges to Alcoholic Cardiomyopathy.
Diagnostics (Basel)
June 2024
Department of Health Promotion Sciences, Maternal and Child Care, Internal Medicine and Medical Specialties "Giuseppe D'Alessandro", University of Palermo, Via del Vespro 133, 90127 Palermo, Italy.
Article Synopsis
- - Frequent and excessive alcohol consumption is a major global cause of death, leading to severe health issues, particularly related to the heart.
- - Binge drinking can trigger "Holiday Heart Syndrome," which may cause dangerous irregular heartbeats, while long-term abuse contributes to alcoholic cardiomyopathy, a serious heart condition.
- - Alcohol withdrawal can disrupt normal heart rhythms, increasing death risk, and the review also highlights links to other health problems like high blood pressure, strokes, and Takotsubo syndrome.
Alcohol-related diseases: from metabolism to the main effect on the body.
Minerva Med
October 2024
Department of Translational Medicine, Center for the Study and Treatment of Alcohol-Related Diseases, University of Ferrara, Ferrara, Italy.
Article Synopsis
- Alcohol consumption is associated with around 200 diseases and at least 14 types of cancer, with the WHO reporting that a significant portion of alcohol-related deaths in 2016 were due to cancer, liver cirrhosis, and cardiovascular disorders.
- The majority of ethanol absorbed (about 90%) is metabolized in the liver into acetaldehyde, which is toxic and can lead to serious health issues like liver diseases and heart problems.
- Even moderate drinking doesn't lower mortality risk and is a major contributor to various health issues, highlighting the need for greater awareness about its dangers to public health.*
Alcoholic cardiomyopathy: an update.
Eur Heart J
July 2024
Department of Cardiology, Heart Failure and Inherited Cardiac Diseases Unit, Hospital Universitario Puerta de Hierro Majadahonda, IDIPHISA, CIBERCV, Manuel de Falla, 2, Majadahonda, Madrid 28222, Spain.
Article Synopsis
- - Alcohol-induced cardiomyopathy (AC) is a type of heart disease caused by heavy alcohol consumption, typically requiring more than 80 grams of alcohol per day for at least 5 years, and involves both genetic and environmental factors.
- - The damage from alcohol is linked to oxidative stress, the toxic effects of alcohol metabolites like acetaldehyde, and genetic variants that exacerbate the condition, suggesting a "double-hit" hypothesis where both genetics and alcohol contribute to AC.
- - Treatment primarily focuses on abstaining from alcohol, which can lead to recovery, while ongoing research aims to develop targeted therapies based on AC's underlying mechanisms to improve treatment outcomes.
Socio-economic association of alcohol use disorder and cardiovascular and alcohol-associated liver disease from 2010 to 2019.
Aliment Pharmacol Ther
August 2024
Division of Gastroenterology and Hepatology, Department of Medicine, University of Arizona College of Medicine, Phoenix, Arizona, USA.
Article Synopsis
- Alcohol consumption is linked to significant health issues worldwide, including alcohol use disorder (AUD), liver disease, and heart disease, contributing to increased disability and mortality rates, especially among lower socio-economic groups.
- In 2019, AUD had the highest rate of disability-adjusted life years, with liver disease and alcohol-induced heart problems also notable, although some rates showed slight declines.
- The burden of alcohol-related health complications is rising particularly in low and low-middle income countries, highlighting an urgent need for effective public health strategies to tackle these challenges.