4 results match your criteria: "Cardiometabolic and Endocrine Institute[Affiliation]"

Human skin is a physical and biochemical barrier that protects the internal body from the external environment. Throughout a person's life, the skin undergoes both intrinsic and extrinsic aging, leading to microscopic and macroscopic changes in its morphology. In addition, the repair processes slow with aging, making the older population more susceptible to skin diseases.

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Article Synopsis
  • Vitamin D is crucial for various aspects of health, including bone strength and immune function, with studies showing that higher levels may reduce risks of several health issues like cardiovascular diseases and diabetes.
  • Vitamin D operates through two systems: the endocrine system, which manages calcium levels and muscle function, and the intracrine/paracrine system, which affects cellular signaling and gene expression.
  • Existing clinical guidelines on vitamin D primarily focus on bone health due to the 2011 Institute of Medicine report, overlooking broader health benefits, thus new guidelines should consider comprehensive health and disease prevention rather than just skeletal effects.
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The interaction of the SARS-CoV-2 spike protein with membrane-bound angiotensin-converting enzyme-2 (ACE-2) receptors in epithelial cells facilitates viral entry into human cells. Despite this, ACE-2 exerts significant protective effects against coronaviruses by neutralizing viruses in circulation and mitigating inflammation. While SARS-CoV-2 reduces ACE-2 expression, vitamin D increases it, counteracting the virus's harmful effects.

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