The Pathophysiological Basis of Diabetic Cardiomyopathy Development.

Diabetes mellitus (DM) provokes widely known structural and functional dyscoordination of the myocardium performance. A cascade of pathophysiological changes occurs due to metabolic disorders caused by hyperglycemia, insulin resistance, and dyslipidemia. Free fatty acids can stimulate oxidation and accumulate in the cytosol, leading to lipotoxic effects by forming ceramides, diacylglycerol, and reactive oxygen species (ROS).

[Factors for unfavorable prognosis in elderly patients with previous acute myocardial infarction. The role of the ambulatory rehabilitation stage.].

The paper presents the results of the study of the long-term post-infarction period in elderly patients with 5 years survival after myocardial infarction. The factors and features of the ambulatory rehabilitation stage that have a significant impact on the long-term post-infarction period have been established. It is shown that a regular follow up at the ambulatory rehabilitation stage along with such risk factors as the volume of coronary lesions, burdened history, complicated during the acute period of myocardial infarction have a significant impact on the post-infarction period.

[Hybrid treatment of the ascending aortic aneurysm and "shaggy aorta" syndrome].

This case report describes simultaneous approach that enables to replace the ascending aortic aneurysm complicated with atherosclerotic lesions of the descending aorta (the "shaggy aorta" syndrome) using frozen elephant trunk technique.