Prevalence and determinants of valvulopathy in patients treated with dexfenfluramine.

Background: Valve regurgitation has been associated with dexfenfluramine, but its prevalence and severity are uncertain. Additional factors that may contribute to valve regurgitation in patients exposed to this drug are poorly understood.

Methods And Results: Echocardiography was performed on subjects recruited from 26 prescribing sites in 15 states.