1 results match your criteria: "Cardiology Division at the University of California Los Angeles[Affiliation]"
A systems genetics approach identifies as a link between cardiomyocyte glucose utilization and hypertrophic response.
Am J Physiol Heart Circ Physiol
April 2017
Department of Medicine, Cardiology Division at the University of California Los Angeles, Los Angeles, California; and
Article Synopsis
- Cardiac failure is linked to increased glucose utilization, prompting a study to explore the connection between hyperglycemia and heart failure.
- Researchers screened mouse models and used rat heart cells to identify how glucose availability affects gene expression.
- The study found that silencing a specific gene reduced glycolytic enzyme levels, glucose uptake, and cell size changes in heart cells, suggesting this gene plays a crucial role in regulating heart cell metabolism and hypertrophic response when glucose levels are high.