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Effect of Colchicine on Myocardial Injury in Acute Myocardial Infarction.
Circulation
September 2021
Cardiology Department CHRU de Tours and EA4245 T2i Tours University, France (F.I., D.A.).
Article Synopsis
- This study investigated if colchicine, an anti-inflammatory medication, could reduce heart damage and remodeling after a ST-segment-elevation myocardial infarction (a type of heart attack) by comparing it to a placebo in a double-blind trial.
- The trial included 192 patients, with no significant differences in heart damage or remodeling observed between the colchicine and placebo groups at both 5 days and 3 months post-treatment.
- However, patients taking colchicine experienced higher rates of gastrointestinal side effects compared to those on the placebo, suggesting a potential drawback of the treatment.