2 results match your criteria: "Cardiocerebral Vascular Disease Hospital of General Hospital of Ningxia Medical University[Affiliation]"
Human placental mesenchymal stem cells transplantation repairs the alveolar epithelial barrier to alleviate lipopolysaccharides-induced acute lung injury.
Biochem Pharmacol
November 2024
Clinical Medical College of Ningxia Medical University, Yinchuan Province 750004, China; Intensive Care Unit, Cardiocerebral Vascular Disease Hospital of General Hospital of Ningxia Medical University, Yinchuan Province 750002, China. Electronic address:
Article Synopsis
- Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) have high mortality rates with limited treatment options, prompting research into human placental mesenchymal stem cells (hPMSCs) as a potential remedy.
- The study involved inducing ALI in mice using lipopolysaccharide (LPS) and administering hPMSCs, showing improved lung health and reduced inflammation through changes in key inflammatory markers.
- Findings indicated that the presence of the ACE2 gene is vital for the therapeutic effects of hPMSCs, suggesting a significant role in repairing lung tissue and providing a basis for future clinical treatments for ALI.
[Effect of human placental mesenchymal stem cells transplantation on pulmonary vascular endothelial permeability and lung injury repair in mice with acute lung injury].
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
March 2020
Intensive Care Unit, Cardiocerebral Vascular Disease Hospital of General Hospital of Ningxia Medical University, Yinchuan Ningxia, 750012, P.R.China.
Objective: To investigate the effects of human placental mesenchymal stem cells (hPMSCs) transplantation on pulmonary vascular endothelial permeability and lung injury repair in mice with lipopolysaccharide (LPS)-induced acute lung injury (ALI).
Methods: The hPMSCs were isolated from the human placental tissue by enzyme digestion and passaged. The cell phenotype of the 3rd generation hPMSCs was detected by flow cytometry.